Antibiotics in Colon Surgery

Cohn, Isidore; Ab, Longacre

doi:10.1097/00007611-195610000-00005

Cited by 6 publications

(3 citation statements)

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“…Cohn in 1958 hypothesized that identifying a single antibiotic agent that would possess Poth's criteria would be unlikely. 23 He delineated that his three major requirements for an effective intestinal antiseptic agent were high bactericidal activity against pathogenic organisms in the gastrointestinal tract (accomplished in a rapid fashion), the ability to prevent development or overgrowth of pathogenic organisms, and low toxicity (local and systemic), combined with a limited absorption of the agent from the intestine. In an attempt to find the ideal antibiotic combination, Cohn would study 48 different regimens with an attempt to provide the optimal intestinal antisepsis.…”

Section: Characteristics Of the Ideal Oral Antibioticmentioning

confidence: 99%

“…In an attempt to find the ideal antibiotic combination, Cohn would study 48 different regimens with an attempt to provide the optimal intestinal antisepsis. 23 Unfortunately, these studies were carried out before it was understood that that B. fragilis is the dominant constituent of the colonic microflora. This led to aminoglycosides and sulfonamides being the most frequently used agents, but with their lack of anaerobic coverage, success was limited and they failed to gain widespread clinical acceptance.…”

Section: Characteristics Of the Ideal Oral Antibioticmentioning

confidence: 99%

“…Hundreds of studies using various combinations of these new agents would eventually lead to the identification of protocols incorporated in our present armamentarium. 23…”

Section: Characteristics Of the Ideal Oral Antibioticmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Perioperative Antibiotics in Colorectal Surgery

2003

Clinics in Colon and Rectal Surgery

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After more than the 60 years since the first report of antibiotic use for prevention of infection following colorectal surgery, the knowledge base has increased dramatically. Despite this expansion of knowledge, the appropriate use of prophylactic antibiotics remains controversial. Options include intravenous antibiotics, oral antibiotics, or both. The available data support concomitant use of oral and intravenous antibiotics and, perhaps more importantly, appropriate timing of the intravenous antibiotics within 2 hours (or less) of surgery start time. In selecting an oral antibiotic regime, it is imperative that both aerobic and anaerobic activities are present in the antibiotics used (i.e., neomycin plus metronidazole or erythromycin base). If a parenteral antibiotic is used without a combination of an oral antimicrobial, it must adhere to the same broad-spectrum coverage of both aerobes and anaerobes. Oral agents should be administered in limited doses the day before the operation. Parenteral antibiotics must be administered in a timely fashion to ensure that adequate tissue levels are present at the time of the incision and be of adequate duration to produce adequate tissue levels during the expected duration of contamination Objectives: Upon completion of this article, the reader should understand the role of perioperative antibiotics in colorectal surgery.

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Section: Characteristics Of the Ideal Oral Antibioticmentioning

confidence: 99%

Section: Characteristics Of the Ideal Oral Antibioticmentioning

confidence: 99%