Critical Analysis of Intestinal Antisepsis

Poth, Edgar J.

doi:10.1001/jama.1957.02970500001001

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Discussion1

Antibiotic Decontamination Of the Digestive Tract1

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1957

1992

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Cited by 49 publications

(2 citation statements)

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“…The incidence of the S aureus in wound infections and enterocolitis. 3. Bacteriophage typing results of the Staphylococcus to establish any relationship of the infections to the Staphylococcus emerging in the colon during and after antibiotic bowel prep¬ aration.…”

Section: Discussionmentioning

confidence: 99%

Surgery of the Colon

Beahrs¹,

Hoehn²,

Dearing³

1969

Arch Surg

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Section: Discussionmentioning

confidence: 99%

Surgery of the Colon

Beahrs¹,

Hoehn²,

Dearing³

1969

Arch Surg

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“…The third approach to treatment/prevention of bacterial infection in immunocompromised mice was the application of oral treatment, starting before irradiation, with non-absorbable antibiotics [16] according to directions outlined by an American surgeon Poth [17]. We gave extra attention to prevention, because it might not only become clinically applicable, but successful infection prevention might be beneficial to the radiobiologists in the institue.…”

Section: Antibiotic Decontamination Of the Digestive Tractmentioning

confidence: 99%

Selective Gastrointestinal Decontamination History of recognition and measurement of colonization resistance of the digestive tract as an introduction to selective gastrointestinal decontamination

Waaij

1992

Epidemiol. Infect.

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Selective decontamination of the digestive tract was developed following the observation that the digestive tract normally has considerable resistance to colonization by newly ingested bacteria. The research that eventually led to selective decontamination was performed because in the late 1960s and early 1970s, the need for prophylaxis against Gram-negative infections in immuno-compromized patients became evident. At that time, the relatively small number of antibiotics available for therapy of serious infections often lead to treatment failure. To introduce the subject of selective decontamination, this paper, therefore, starts with a short historical overview of the kind of infectious agents as well as the antibiotics available in the 1960s; particularly regarding the type and treatment of infections in severely compromised patients. The fact that the possibilities in infectious diseases were limited was the reason for our experimental search for ways of successful prophylactic treatment with minimal risk of development of resistance.

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Protected environment for cancer patients. Effect of a prophylactic antibiotic regimen on the microbial flora of patients undergoing cancer chemotherapy

Bodey¹

1968

Archives of Internal Medicine

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Critical Analysis of Intestinal Antisepsis

Cited by 49 publications

References 1 publication

Surgery of the Colon

Surgery of the Colon

Selective Gastrointestinal Decontamination History of recognition and measurement of colonization resistance of the digestive tract as an introduction to selective gastrointestinal decontamination

Protected environment for cancer patients. Effect of a prophylactic antibiotic regimen on the microbial flora of patients undergoing cancer chemotherapy

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