Antibiotic susceptibility pattern of Neisseria gonorrhoeae strains isolated from five cities in India during 2013–2016

Abstract

Our data suggest that the disc diffusion method which is both cost effective and more feasible, can effectively be used routinely for monitoring antibiotic susceptibility in N. gonorrhoeae, in limited resource countries like India. We demonstrate the emergence of decreased susceptibility to ceftriaxone and cefixime and threshold levels of resistance to azithromycin in India. This underscores the importance of maintaining continued surveillance for antibiotic resistance in N. gonorrhoeae and a potential requirement for strategic change in guidelines in the not so distant future.

Clinical and Bacteriological Profile of Male Patients with Urethral Discharge at Western Regional Hospital, Nepal

“…These findings are similar to the study by Buder S et al in 2014 where among all the NG isolates sensitive to ceftriaxone, two NG isolates showed minimum inhibitory concentration (MIC) at estimated breakpoint 0.125 mg/L. 15 A study done from five cities of India by Kulkarni SV et al (2018) and also another study by T Wi et al found decreased susceptibility of NG isolates to ceftriaxone similar to our findings. 16,17 In our study one NG(4.76%) isolate was only of intermediate sensitivity to cefixime.…”

“…15 A study done from five cities of India by Kulkarni SV et al (2018) and also another study by T Wi et al found decreased susceptibility of NG isolates to ceftriaxone similar to our findings. 16,17 In our study one NG(4.76%) isolate was only of intermediate sensitivity to cefixime. Nine NG isolates (42.85%) were resistant to cefixime.…”

Mechanism of action, resistance, synergism, and clinical implications of azithromycin

“…gonorrhoeae isolates—5% and 14.6%, respectively. 75 , 79 The resistance mechanism mentioned in relation to these resistant isolates was mutations in 23S rRNA, penA , and mtrA genes. 83 , 85 The susceptibility assessment of Campylobacter spp.…”

Schnelltests bei sexuell übertragbaren Infektionen

“…Momentan zeichnet sich vor allem für Azithromycin eine Resistenzentwicklung ab, in seltenen Fällen auch mit Ausprägung von high-level Resistenzen. Aus Asien (China) wurden kürzlich Resistenzraten gegen Azithromycin von 18,6% berichtet 51 , aus Indien 5% 52 . In der Euro-GASP Surveillance wurde 2015 für Gesamteuropa eine Resistenzrate von 7,1% nachgewiesen (Euro-GASP Report 2015 53 ), mit starker landestypischer Streuung (von 0%-22%) 54-60 . Aktuelle epidemiologischen Daten aus England (GRASP-Report Juni 2017) 61 zeigen einen leicht abgeschwächten Trend bei der Entwicklung der Azithromycin-Resistenz (von 9,8% 2015 auf 4,7% 2016), was jedoch aus methodischen Gründen noch mit Vorsicht zu bewerten ist.…”