Antibiotic susceptibility of bacteria isolated from diabetic foot infections and prospects for empiric antibiotic therapy in Ouagadougou (Burkina Faso)

Guira, Oumar; Tiéno, H.; Sagna, Yempabou; Yaméogo, Tènè Marceline; Zoungrana, Lassané; Traoré, Si Simon; Diallo, I; Yanogo, D.; Drabo, Y.J.

doi:10.1684/mst.2015.0493

Cited by 5 publications

(7 citation statements)

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“…Initial antibiotic treatment is given empirically, and later antibiotics are modified to the report of culture and sensitivity [1][2][3]5,[33][34][35][36]175,176]. Cultures of superficial swab specimens are not especially useful since they tend to yield polymicrobial growth: obtaining deep tissue biopsies for culture and sensitivity is likely to give more useful information [144,[177][178][179][180][181][182][183][184][185][186][187][188][189][190][191][192]. However, many microbiology services in resource-poor countries do not have facilities to analyse biopsy specimens on a routine basis [1][2][3]33,177].…”

Section: Foot Infectionmentioning

confidence: 99%

Diabetic foot ulcer disease in African continent: ‘From clinical care to implementation’ – Review of diabetic foot in last 60 years – 1960 to 2020

Abbas¹,

Boulton²

2022

Diabetes Research and Clinical Practice

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The prevalence of diabetes mellitus is increasing globally and the greatest potential increases in diabetes will occur in Africa. Data suggest that these increases is associated with rapid demographic, sociocultural and economic transitions. There will be a parallel increase in the complications of diabetes and among the various complications those related to diabetic foot disease are associated with the highest morbidity and mortality.Diabetic Peripheral neuropathy (DPN) is the most common cause of diabetic foot complications in African countries; however, peripheral arterial disease (PAD) appears to increase, possibly a result of rising urbanization. Search done for the past six decades (1960 to 2020) on all foot complications.Rates of complications of diabetic foot in last six decades varied by country as follow: DPN: 4-90%; PAD: 0-77%; foot ulcers: 4-61%; amputation rates: 3-61% and high mortality rates reaching to 55%, patients who presented late with infection and gangrene.Educational and prevention programmes are required to curb the growing complications of diabetic foot ulcers in Africa among patients and health care workers. Secondly, it is imperative that governments across the African continent recognise the clinical and public health implications of diabetic foot disease in persons with diabetes.

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Section: Foot Infectionmentioning

confidence: 99%

Diabetic foot ulcer disease in African continent: ‘From clinical care to implementation’ – Review of diabetic foot in last 60 years – 1960 to 2020

Abbas¹,

Boulton²

2022

Diabetes Research and Clinical Practice

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“…Patients with foot ulcers have a high incidence of infections, and 40% to 70% of them have had infections when they seek medical treatment (6). Studies from different countries have shown that different degrees of infection in patients with DFI lead to different pathogenic microorganism distributions and drug sensitivities (7)(8)(9). Current studies have found that the microbial distribution of diabetic foot infections varies in different seasons in different countries (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China

et al. 2023

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BackgroundTo investigate the distribution of microbes and drug susceptibility in patients with diabetic foot infections (DFI) and provide guidance for clinical empirical treatment and the rational selection of antibacterial drugs.MethodsRetrospective analysis of the pathogenic bacterium distribution and antimicrobial susceptibility isolated from 581 DFI patients with different Wagner grades.ResultsThe 534 positive samples included 473 cases (88.58%)) of monomicrobial infections and 61 cases (11.42%) of polymicrobial infections before antibiotic therapy. A total of 656 strains were cultivated, including 387 (58.99%) strains of gram-positive organisms (GPOs), 235 (35.82%) gram-negative bacilli (GNB), and 21 (3.20%) fungal strains. Polymicrobial infections mainly occurred in patients with Wagner grade 3-4 ulcers. GPOs were predominant in Wagner grades 1-3 (grade 1: 96.67%, grade 2: 76.52%, grade 3 62.81%), and the most common was Staphylococcus aureus (grade 1: 31.66%, grade 2: 33.04%, grade 3 35.53%). GNB were predominant in grades 4-5 (grade 4: 51.46%, grade 5:60%), and the most common GNB in Wagner grades 4-5 was Proteus (grade 4:27.88%, grade 5: 42.86%), while the most common GPO was Enterococcus (grade 4:34.48%, grade 5:25.00%). Staphylococcus (including MRSA) and Enterococcus were still highly sensitive to vancomycin, linezolid, and tigecycline. Most GNB were still highly sensitive to meropenem, tigecycline, ertapenem, and amikacin. Proteus was most sensitive to amikacin (97.14%), followed by meropenem (92%) and ertapenem (80%).ConclusionThe distribution of microbes and antimicrobial susceptibility in DFI patients varied with different Wagner grades. The most appropriate antimicrobial therapy should be selected based on the pathogen culture and antimicrobial susceptibility.

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“…Control of DFIs in a timely and effectively manner has become an urgent problem for clinicians. Studies from different countries have revealed different DFI-related microbial compositions and drug susceptibilities [ 6 – 8 ], and the ratios of patients associated with multidrug resistance (MDR), methicillin-resistant Staphylococcus (MRS), and extended-spectrum β -lactamase (ESBL) bacterial infections have increased every year, suggesting that administration of empirical anti-infective regimens will increase the chances of treatment failure. China has a large population of DFI patients with a vast geographical distribution and significant variations in the types of bacterial infections found in DFI wounds from different regions.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Microbes and Drug Susceptibility in Patients with Diabetic Foot Infections in Southwest China

Pan

Leng

et al. 2018

Journal of Diabetes Research

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Objective To investigate the microbial distribution and drug susceptibility among diabetic foot ulcers (DFUs) with different Wagner grades and between acute and chronic DFUs. Methods. We enrolled 428 DFU patients who were hospitalized and treated in the Southwest Hospital. We collected deep ulcer secretion for microbial culture and drug susceptibility tests and analyzed the results. We reexamined 67 patients with poor anti-infection efficacy and analyzed microbial species. Results: The 354 positive samples included 201 cases (56.8%) of single-pathogen infections and 153 cases (43.2%) of multiple-pathogen infections before antibiotic therapy. A total of 555 strains were cultivated, including 205 (36.9%) strains of gram-positive organisms (GPOs), 283 (51.0%) gram-negative bacilli (GNB), and 67 (12.1%) fungal strains. In terms of distribution, patients with different Wagner grades had different bacterial composition ratios (P < 0.01). Patients with Wagner grades 3–5 mainly had GNB. The specimens from chronic ulcer wounds were primarily GNB (54.2%), whereas fungi accounted for 14.4% of the infections; the distribution was significantly different from that of acute ulcers (P < 0.01). The susceptibility tests showed that the Staphylococcus genus was more susceptible to vancomycin, linezolid, and tigecycline. Tobramycin was the most effective drug (97%) for the treatment of Escherichia coli, followed by ertapenem (96.4%), imipenem (93.5%), and cefotetan (90%). Most of the remaining GNB were susceptible to antibiotics such as carbapenems, aminoglycosides, fluoroquinolones, ceftazidime, cefepime, and piperacillin-tazobactam (>63.2%). After antibiotic therapy, the positive rate of microbial culture was 52.2%, and the proportion of GNB and fungi increased to 68.9% and 20%. Conclusion The distribution and types of bacteria in diabetic foot infection (DFI) patients varied with the different Wagner classification grades, courses of the ulcers, and antibiotic therapy. Multidrug resistance were increased, and the clinical treatment of DFIs should select the most suitable antibiotics based on the pathogen culture and drug susceptibility test results.

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Antibiotic susceptibility of bacteria isolated from diabetic foot infections and prospects for empiric antibiotic therapy in Ouagadougou (Burkina Faso)

Cited by 5 publications

References 0 publications

Diabetic foot ulcer disease in African continent: ‘From clinical care to implementation’ – Review of diabetic foot in last 60 years – 1960 to 2020

Diabetic foot ulcer disease in African continent: ‘From clinical care to implementation’ – Review of diabetic foot in last 60 years – 1960 to 2020

Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China

Distribution of Microbes and Drug Susceptibility in Patients with Diabetic Foot Infections in Southwest China

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