Diabetic foot ulcer disease in African continent: ‘From clinical care to implementation’ – Review of diabetic foot in last 60 years – 1960 to 2020

Abbas, Zulfiqarali G.; Boulton, Andrew J.M.

doi:10.1016/j.diabres.2021.109155

Cited by 31 publications

(35 citation statements)

References 131 publications

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“…Many patients treated corns, calluses and wounds on their own. This is consistent with the findings of studies conducted around the world ( 34 – 36 ). Patients chose to self-treat their foot problems, possibly due to a lack of foot-care knowledge or poor availability of medical facilities in rural areas.…”

Section: Discussionsupporting

confidence: 93%

Knowledge, Attitudes, and Practices Associated With Diabetic Foot Prevention Among Rural Adults With Diabetes in North China

Jia

Wang

Cheng

2022

Front. Public Health

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BackgroundThe diabetic foot is a global threat to public health because it can result in infection and amputation, as well as cause the patient to experience considerable pain and incur financial costs. The condition of patients with diabetic foot in North China is distinguished by more severe local ulcers, a worse prognosis, and a longer duration of disease than that of patients with diabetic foot in the south. Through appropriate preventive measures, the diabetic foot can be effectively avoided. This study assesses the existing knowledge, attitudes and practices associated with diabetic foot prevention among adults with diabetes living in rural areas of North China.MethodThis cross-sectional survey included 1,080 rural adults from North China, cluster sampled 12 villages and surveyed diabetic patients without diabetic foot who participated in community diabetes management. The self-administered knowledge and attitude questionnaire and the Chinese version of the Nottingham Assessment of Functional Foot-care Questionnaire were used.ResultOf the 1,080 subjects, 51.6% received moderate knowledge scores, 63.9% had a positive attitude and 71.4% received poor practice scores. In terms of knowledge, parameters of knowledge about foot examinations and treatment of foot problems showed the lowest scores. In terms of practice, in line with the results of the low knowledge score, parameters of the pursuit of medical treatment for foot problems and routine foot examinations were associated with the lowest scores. Multiple regression analysis revealed that participants who were current smokers (β: −0.049, 95% CI: −0.088 to −0.011) had lower knowledge scores than those who never smoke; participants who were current smokers (β: −0.818, 95% CI: −1.067 to −0.569) and past smokers (β: −0.299, 95% CI: −0.485 to −0.112) had lower attitude scores than those who had never smoked; participants who had higher knowledge scores (β: 1.964, 95% CI: 1.572–2.356) achieved higher scores on attitudes; women had better practice scores than men (β: 0.180, 95% CI: 0.122–0.239); patients with a long diabetes duration (6–10 years) had better practice scores than those who had a short diabetes duration (<2 years; β: 0.072, 95% CI: 0.012–0.131). Knowledge (β: 0.130, 95% CI: 0.001–0.258) and attitudes (β: 0.268, 95% CI: 0.249–0.287) were significantly associated with good practices.ConclusionsIncreasing knowledge regarding diabetic foot would help instill positive attitudes and cultivate better practices toward diabetic foot prevention. The results of this study may help guide future promotional resources to those groups most in need, which may help lower the incidence of diabetic foot among adults in North China.

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Section: Discussionsupporting

confidence: 93%

Knowledge, Attitudes, and Practices Associated With Diabetic Foot Prevention Among Rural Adults With Diabetes in North China

Jia

Wang

Cheng

2022

Front. Public Health

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“…1 Data has suggested that this increase is connected to rapid demographic, sociocultural and economic transitions. 3 …”

Section: Introductionmentioning

confidence: 99%

“…1 Data has suggested that this increase is connected to rapid demographic, sociocultural and economic transitions. 3 With an increase in diabetes comes a rise in micro-and macrovascular complications, which could negatively impact the health of diabetic patients. This together with neuropathy leads to further complications and an increase in the incidence of lower limb amputations due to non-healing diabetic foot ulcers (DFUs).…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation at 830 nm Stimulates Migration, Survival and Proliferation of Fibroblast Cells

Oyebode¹,

Houreld²

2022

DMSO

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Purpose Photobiomodulation (PBM) promotes diabetic wound healing by favoring cell survival and proliferation. This study aimed to investigate the potential of PBM in stimulating cellular migration, viability, and proliferation using the transforming growth factor-β1 (TGF-β1)/Smad signaling pathway. Methods The study explored the in vitro effects of near infrared (NIR) light on cell viability (survival) and proliferation as well as the presence of TGF-β1, phosphorylated TGF‐β receptor type I (pTGF-βR1) and phosphorylated mothers against decapentaplegic‐homolog (Smad)‐2/3 (p-Smad2/3) in different fibroblast cell models. Results Results show a significant increase in cellular migration in wounded models, and increased viability and proliferation in irradiated cells compared to their respective controls. An increase in the presence of TGF-β1 in the culture media, a reduction in pTGF-βR1 and a slight presence of p-Smad2/3 was observed in the cells. Conclusion These findings show that PBM at 830 nm using a fluence of 5 J/cm 2 could induce cell viability, migration and proliferation to favor successful healing of diabetic wounds. This study contributes to the growing body of knowledge on the molecular and cellular effect of PBM and showcases the suitability of PBM at 830 nm in managing diabetic wounds.

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“…Diabetic foot ulcers are a common complication in diabetics. Diabetic foot ulcers can cause substantial disability, which can reduce life expectancy (Abbas and Boulton, 2022). Research result of Almobarak et al (2017) showed that the prevalence of diabetic foot ulcers in type 2 Diabetes Mellitus was 18.1%.…”

Section: Introductionmentioning

confidence: 99%

Exercise intervention to reduce the risk of diabetic foot ulcers in diabetics with the health belief model approach

Mulyaningsih¹,

Qadrijati²,

Mulyani³

et al. 2022

ijhs

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Diabetic foot ulcers are common complication in diabetics. This study aims to explore the effect of exercise on the risk of diabetic foot ulcers in diabetics using the Health Belief Model approach. One of the essential benefits of this study is to reduce the risk of developing diabetic foot ulcers, thereby reducing disability rates. The problem of diabetic foot ulcers can be prevented by implementing exercise interventions. In this experimental study, there were three groups, with 161 diabetics as respondents. Group one and group two were given different interventions, while group three was the control group. In this study, changes in the ankle-brachial index and the effect of Health Belief Model on activeness in the intervention were measured. Follow-up was done after three months of intervention. All aspects of the Health Belief Model scale were different in the three groups. Perceptions of obstacles showed the most significant difference (p=<0.001). All aspects of the Health Belief Model scale also affect the activity of diabetics in doing exercise (p=0.001). The results of the ankle-brachial index measurement showed that there were differences between the three groups (p=0.019) and the “MULDA” exercise group had the highest median value.

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Diabetic foot ulcer disease in African continent: ‘From clinical care to implementation’ – Review of diabetic foot in last 60 years – 1960 to 2020

Cited by 31 publications

References 131 publications

Knowledge, Attitudes, and Practices Associated With Diabetic Foot Prevention Among Rural Adults With Diabetes in North China

Knowledge, Attitudes, and Practices Associated With Diabetic Foot Prevention Among Rural Adults With Diabetes in North China

Photobiomodulation at 830 nm Stimulates Migration, Survival and Proliferation of Fibroblast Cells

Exercise intervention to reduce the risk of diabetic foot ulcers in diabetics with the health belief model approach

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