Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China

Liu, Wei; Song, Lingyun; Sun, Wen-Jin; Fang, Weijin; Wang, Chun‐Jiang

doi:10.3389/fendo.2023.1113622

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…In line with our results, Liu et al 20 showed that Staphylococcus and Streptococcus were resistant to clindamycin and erythromycin but susceptible to Vancomycin, Linezolid, and Tigecycline. Gramnegative bacteria remained highly sensitive to Meropenem, Tigecycline, and Amikacin.…”

Section: Discussionsupporting

confidence: 93%

Assessment of Bacterial Isolates from Diabetic Foot Ulcers and Their Antimicrobial Susceptibility Patterns among Diabetic Patients Attending Kafr El Sheikh University Hospital

El nahal,

Mabrouk,

Eissa

et al. 2024

Egyptian Journal of Medical Microbiology

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Background: Diabetic foot ulcers (DFU) are one of the most frequent consequences of diabetes mellitus. Having an ulcer in a diabetic foot significantly affects a person's quality of life due to reduced physical function and reduced mobility. Objectives: to recognize the bacteria responsible for ulcers in the diabetic foot, to assess their antibiotic sensitivity, and to ascertain if infections in the diabetic foot frequently contain multi-drug-resistant bacteria. Methodology: Fifty diabetic individuals with diabetic foot ulcers attending the

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Section: Discussionsupporting

confidence: 93%

Assessment of Bacterial Isolates from Diabetic Foot Ulcers and Their Antimicrobial Susceptibility Patterns among Diabetic Patients Attending Kafr El Sheikh University Hospital

El nahal,

Mabrouk,

Eissa

et al. 2024

Egyptian Journal of Medical Microbiology

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Prevalence of multidrug‐resistant bacterial infections in diabetic foot ulcers: A meta‐analysis

Yang,

Hu,

Zhao

et al. 2024

International Wound Journal

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Multidrug‐resistant (MDR) bacterial infections have become increasingly common in recent years due to the increased prevalence of diabetic foot ulcers (DFUs). We carried out a meta‐analysis aimed at investigating the prevalence of MDR bacteria isolated from DFUs and analysing the risk factors for MDR bacterial infection in patients with DFUs. The PubMed/Medline, Web of Science, Embase, Cochrane Library, Ovid, Scopus, and ProQuest databases were searched for studies published up to November 2023 on the clinical outcomes of MDR bacteria in DFUs. The main outcome was the prevalence of MDR bacteria in DFUs. A total of 21 studies were included, representing 4885 patients from which 2633 MDR bacterial isolates were obtained. The prevalence of MDR bacteria in DFUs was 50.86% (95% confidence interval (CI): 41.92%–59.78%). The prevalence of MDR gram‐positive bacteria (GPB) in DFUs was 19.81% (95% CI: 14.35%–25.91%), and the prevalence of MDR gram‐negative bacteria (GNB) in DFUs was 32.84% (95% CI: 26.40%–39.62%). MDR Staphylococcus aureus (12.13% (95% CI: 8.79%–15.91%)) and MDR Enterococcus spp. (3.33% (95% CI: 1.92%–5.07%)) were the main MDR‐GPB in DFUs. MDR Escherichia coli, MDR Pseudomonas aeruginosa, MDR Enterobacter spp., MDR Klebsiella pneumoniae, and MDR Proteus mirabilis were the main MDR‐GNB in DFUs. The prevalence rates were 6.93% (95% CI: 5.15%–8.95%), 6.01% (95% CI: 4.03%–8.33%), 3.59% (95% CI: 0.42%–9.30%), 3.50% (95% CI: 2.31%–4.91%), and 3.27% (95% CI: 1.74%–5.21%), respectively. The clinical variables of diabetic foot ulcer patients infected with MDR bacteria and non‐MDR bacteria in the included studies were analysed. The results showed that peripheral vascular disease, peripheral neuropathy, nephropathy, osteomyelitis, Wagner's grade, previous hospitalization and previous use of antibacterial drugs were significantly different between the MDR bacterial group and the non‐MDR bacterial group. We concluded that there is a high prevalence of MDR bacterial infections in DFUs. The prevalence of MDR‐GNB was greater than that of MDR‐GPB in DFUs. MDR S. aureus was the main MDR‐GPB in DFUs, and MDR E. coli was the main MDR‐GNB in DFUs. Our study also indicated that peripheral vascular disease, peripheral neuropathy, nephropathy, osteomyelitis, Wagner's grade, previous hospitalization, and previous use of antibacterial drugs were associated with MDR bacterial infections in patients with DFUs.

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Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China

Cited by 2 publications

References 39 publications

Assessment of Bacterial Isolates from Diabetic Foot Ulcers and Their Antimicrobial Susceptibility Patterns among Diabetic Patients Attending Kafr El Sheikh University Hospital

Assessment of Bacterial Isolates from Diabetic Foot Ulcers and Their Antimicrobial Susceptibility Patterns among Diabetic Patients Attending Kafr El Sheikh University Hospital

Prevalence of multidrug‐resistant bacterial infections in diabetic foot ulcers: A meta‐analysis

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