Antibiotic Resistance in Acinetobacter baumannii Isolated from Patients with Urinary Tract Infections in Zabol, Iran

Abstract

Background: Acinetobacter baumannii are opportunistic pathogens that are found in abundance in Zabol. Due to their unique capability for long-term survival in the hospital environment, the chances of becoming infected with the bacteria are very high. Therefore, identifying potential sources of infection in the donor is very important. The aim of this study was to determine antibiotic resistance in Acinetobacter isolates. Methods: A cross sectional study was performed to evaluate 30 strains of Acinetobacter baumannii, isolated from urine culture of hospitalized patients (Amir-Al-Momenin Hospital, Zabol, South Eastern Iran) with urinary tract infections during a period of 6 months and antibiotic resistance was determined by the disk diffusion method and minimum inhibitory concentration for the antibiotic gentamicin was found with the microdilution method. Results: The results showed that in this study, all antibiotics used on Acinetobacter were effective antimicrobial agents, and only four positions (13.33%) and 26 sensitive points (86.66%) to these antibiotics have been accessed. After chloramphenicol, gentamicin was found as the most active antibiotic in a way that 7 sensitive samples (23.33%) and 23 officials (76.66%) were observed. Results of minimum inhibitory concentration (MIC) showed that four strains of Acinetobacter could grow at all concentrations of gentamicin, while the highest MIC was equal to 1024 micrograms per milliliter. Conclusions: This study demonstrates the increasing resistance of many strains of Acinetobacter baumannii, thus new antibiotics and new treatments are needed.

A Retrospective Cross-sectional Study on Prevalence and Susceptibility Pattern of Bacterial Pathogens Causing Urinary Tract Infections at a Teaching Hospital in Tehran, Iran

“…Despite most reports and in agreement with the results of studies by Rahimi and Rezaie Keikhaie et al, Acinetobacter spp. isolates showed partly good sensitivity to gentamicin (40%) (37,38). In contrast to the results of the current study, Mortazavi et al (39) reported very high resistance to gentamicin and amikacin simultaneously among 80 A. baumannii strains from Ahvaz, south-west Iran.…”

Investigation of Antimicrobial Activity of Solanum nigrum and Saponaria officinalis Extracts Against Acinetobacter baumannii

“…Another study showed that the MIC of gentamicin was 1024 µg/mL (20). In a study by Rigi and Sancholi, who investigated the antimicrobial activity of Solanum nigrum, the results showed that the MICs of the methanolic extract of leaf were 12.5, 25, and 25 ppm against bacteria Aeromonas hydrophila, Yersinia racria, and Streptococcus inuia, respectively (21).…”

QSAR models for the ozonation of diverse volatile organic compounds at different temperatures

“…, SMILES-based, graph-based, and hybrid descriptors (a combination of SMILES and graph) for the creation of QSAR models. 30,31…”