Background: As we know metronidazole is a selective treatment for Trichomoniasis, however, it has many side effects, and, on the other hand, it is important to try finding natural alternative treatments. Objectives: The aim of this study was to investigate the effects of Rosmarinus officinalis plant extract on Trichomonas vaginalis parasites and Candida albicans under laboratory conditions. Methods: In this experimental study, Rosmarinus officinalis methanolic extracts were prepared. The anti-trichomoniasis effect was evaluated at concentrations of 0.1, 0.01, 0.001, 0.0004, 0.0002, and 0.0001 µg/mL in TYIS33 culture media and resulted data were analyzed by ANOVA. Results: The results of this study showed that in the concentration of 0.001 at 4 hours, the parasite was spherical and inactivated, while at concentrations of 0.0004, 0.001, 0.01, and 0.1 in 1 hour. The results of this study showed that Rosmarinus officinalis extract in concentration of 100 µg/mL has an inhibitory effect on Candida albicans, so that the highest inhibitory diameter was 18.3 ± 0.9 mm while two other strains exhibit resistance and no inhibitory zones. Conclusions: The results of this study showed that rosemary extract inhibits the growth of Trichomonas vaginalis and Candida albicans that can be used to treat infections.
Plants as sources of medicinal compounds from ancient times continue to play a major role in maintaining human health. The present study was performed to evaluate of antibacterial activity of Rhazya stricta extract prepared with different solvents on Staphylococcus aureus and Candida albicans isolated from women. The extracts of Rhazya stricta were prepared using a rotary device. The inhibitory concentration against S. aureus and c.albicans was determined using microdulition method. The results of this study showed that, the minimum inhibitory zone diameter of ethyl acetate extract against S.aureus was 1 mm and the maximum inhibitory zone diameter was 8 mm, the lowest inhibitory zone diameter of aqueous extract against S.aureus was 2 mm and the maximum inhibitory zone diameter of aqueous extract was equal to 12 mm. The results of this study showed that the highest inhibitory zone diameter was related to R.stricta extract prepared with ethanol solvent against C.albicans(18 mm) while the lowest inhibitory zone diameter was related to R. stricta extract prepared with ethyl acetate solvent (1 mm).The results of this study showed that the ethanolic extract of R. stricta showed the highest inhibitory properties of S. aureus and C. albicans that can be used in the treatment of infections caused by S.aureus.
Background: Acinetobacter baumannii is a non-fermentative gram-negative bacterium that is common in nosocomial infections. As an opportunistic pathogen in hospitals, it is resistant to a large number of antibiotics and responsible for numerous infections such as bacteremia, pneumonia, meningitis, urogenital infections, and surgical wound infections. Methods: We isolated 10 strains of Acinetobacter baumannii from urine samples of patients referring to Zabol Hospital. Solanum nigrum and Saponaria officinalis plants were harvested from Zabol city, dried in shade, milled, placed in a solvent solution (96% ethanol) for 24 h, and extracted using a rotary machine. The minimum inhibitory concentration (MIC) and the least bactericidal concentration were determined by the microdilution method. Results: The results of the antibiotic resistance testing showed that 100% of the strains were susceptible to antibiotics ceftazidime, gentamycin, and azithromycin while only 16.6% were resistant to ampicillin. The results of antimicrobial activity analysis showed that the least minimum inhibitory concentration of Saponaria officinalis leaves extract was 25 ppm against A. baumannii. Nine strains were inhibited at this concentration and one strain survived at all concentrations. The lowest minimum inhibitory concentration of Solanum nigrum extract was 12.5, with two strains being inhibited at this concentration and seven strains being inhibited at 25. Conclusions: This study showed antimicrobial effects of Solanum nigrum and Saponaria officinalis extracts against A. baumannii. Therefore, they can be proposed as treatments for infections caused by this bacterium.
Background: The aim of this study was to investigate the antimicrobial activity of Mentha piperita , Withania somnifera and Rosmarinus officinalis extract on antibiotic resistant Escherichia coli isolated from poultry stool in Zabol city. Materials & Methods: The extract of Mentha piperita, Rosmarinus officinalis and Withania somnifera was prepared by rotary machine. Escherichia coli strains were isolated from poultry stool samples. Minimum inhibitory concentration and minimum bactericidal concentration were determined by microdilution method. Results: The results of this study showed that Mentha piperita extract showed the highest inhibitory ratio compared to other extracts. The minimum inhibitory concentration was 3.1 ppm, with 5 strains inhibited at this concentration. Discussion: The results of this study could be an effective strategy for production and preparation of medicinal plants to help treating E. coli infections.
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