Antibiotic Releasing Biodegradable Scaffolds for Osteomyelitis

Nair, Manitha B.; Krishnan, Amit G

doi:10.2174/1567201811666140414120002

Cited by 8 publications

(3 citation statements)

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“…To overcome these disadvantages, significant research was devoted to biodegradable polymeric carriers that used several biodegradable materials for osteomyelitis treatment [4][5][6][7][8][9]. Most research focused on poly(lactide-co-glycolide) (PLGA).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)

Liu

XiZhuang

Liang

2016

International Journal of Polymer Science

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Random copolymers of poly(d,l-lactide-co-glycolide-co--caprolactone) (PLGC) were synthesized by the ring-opening polymerization of d,l-lactide (DLLA), glycolide (GA), and -caprolactone (CL). The effects of CL on the copolymers were evaluated to prepare suitable copolymers with controlled properties. Our results showed that the CL content significantly influenced the thermal and mechanical properties of the copolymers and that the CL content in compositions could be altered to control properties of random copolymers. The in vitro hydrolytic degradation of the resulting implants showed that the degradation rate of PLGC was lower than that of PLGA, which could markedly reduce acidic degradation products. Finally, we demonstrated that higher CL contents in compositions slowed degradation rates.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)

Liu

XiZhuang

Liang

2016

International Journal of Polymer Science

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“…However, the main drawback of covalent bonding is the requirement for the treatment of the alloy surface with methacryloxypropyltrimethoxysilane [ 8 ] or bis(ethylene glycol) linkers [ 10 ] so as to enable the subsequent attachment of antibiotics (ATB). In contrast to the low level of efficiency of poly (methyl methacrylate) (PMMA) antibiotic carriers, which have been used in the field of orthopedics for almost 40 years [ 2 , 11 ], biodegradable and resorbable materials enjoy the advantages of the controlled release of antibiotics, broad compatibility with a range of antimicrobial agents, and the dispensing of the need for follow-up surgery for the removal of non-biodegradable carriers [ 12 , 13 , 14 , 15 , 16 , 17 ]. The application of biomaterials in the treatment of implant-associated osteomyelitis was recently comprehensively reviewed by Inzana et al [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-Loaded Collagen/Hydroxyapatite Layers Electrospun on 3D Printed Titanium Implants Prevent Bone Destruction Associated with S. epidermidis Infection and Enhance Osseointegration

et al. 2021

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The aim of the study was to develop an orthopedic implant coating in the form of vancomycin-loaded collagen/hydroxyapatite layers (COLHA+V) that combine the ability to prevent bone infection with the ability to promote enhanced osseointegration. The ability to prevent bone infection was investigated employing a rat model that simulated the clinically relevant implant-related introduction of bacterial contamination to the bone during a surgical procedure using a clinical isolate of Staphylococcus epidermidis. The ability to enhance osseointegration was investigated employing a model of a minipig with terminated growth. Six weeks following implantation, the infected rat femurs treated with the implants without vancomycin (COLHA+S. epidermidis) exhibited the obvious destruction of cortical bone as evinced via a cortical bone porosity of up to 20% greater than that of the infected rat femurs treated with the implants containing vancomycin (COLHA+V+S. epidermidis) (3%) and the non-infected rat femurs (COLHA+V) (2%). The alteration of the bone structure of the infected COLHA+S. epidermidis group was further demonstrated by a 3% decrease in the average Ca/P molar ratio of the bone mineral. Finally, the determination of the concentration of vancomycin released into the blood stream indicated a negligible systemic load. Six months following implantation in the pigs, the quantified ratio of new bone indicated an improvement in osseointegration, with a two-fold bone ingrowth on the COLHA (47%) and COLHA+V (52%) compared to the control implants without a COLHA layer (27%). Therefore, it can be concluded that COLHA+V layers are able to significantly prevent the destruction of bone structure related to bacterial infection with a minimal systemic load and, simultaneously, enhance the rate of osseointegration.

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“…Despite its therapeutic potential, RAL/DOX combination therapy has yet to be explored, and prototype formulations for their localized, controlled release have yet to be evaluated. Given the growing interest in intratrabecular and other modes of direct drug delivery to bone, the successful development of controlled release, combination, controlled release RAL/DOX formulations might be particularly useful for the treatment of isolated bone lesions (5,6).…”

Section: Introductionmentioning

confidence: 99%

Radio Frequency-Activated Nanoliposomes for Controlled Combination Drug Delivery

et al. 2015

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Abstract. This work was conducted in order to design, characterize, and evaluate stable liposomes containing the hydrophobic drug raloxifene HCl (RAL) and hydrophilic doxycycline HCl (DOX), two potentially synergistic agents for treating osteoporosis and other bone lesions, in conjunction with a radio frequency-induced, hydrophobic magnetic nanoparticle-dependent triggering mechanism for drug release. Both drugs were successfully incorporated into liposomes by lipid film hydration, although combination drug loading compromised liposome stability. Liposome stability was improved by reducing the drug load and by including Pluronics® (PL) in the formulations. DOX did not appear to interact with the phospholipid membranes comprising the liposomes, and its release was maximized in the presence of radio frequency (RF) heating. In contrast, differential scanning calorimetry (DSC) and phosphorus-31 nuclear magnetic resonance ( 31 P-NMR) analysis revealed that RAL developed strong interactions with the phospholipid membranes, most notably with lipid phosphate head groups, resulting in significant changes in membrane thermodynamics. Likewise, RAL release from liposomes was minimal, even in the presence of RF heating. These studies may offer useful insights into the design and optimization of multidrug containing liposomes. The effects of RAL on liposome characteristics and drug release performance underscore the importance of appropriate physical-chemical analysis in order to identify and characterize drug-lipid interactions that may profoundly affect liposome properties and performance early in the formulation development process.

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Antibiotic Releasing Biodegradable Scaffolds for Osteomyelitis

Cited by 8 publications

References 0 publications

Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)

Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)

Vancomycin-Loaded Collagen/Hydroxyapatite Layers Electrospun on 3D Printed Titanium Implants Prevent Bone Destruction Associated with S. epidermidis Infection and Enhance Osseointegration

Radio Frequency-Activated Nanoliposomes for Controlled Combination Drug Delivery

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