Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-<i>ε</i>-caprolactone)

Liu, Yixiu; XiZhuang, Bai; Liang, Anna

doi:10.1155/2016/8082014

Cited by 9 publications

(9 citation statements)

References 30 publications

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“…However, it has been demonstrated in our previous studies that the introduction of CL content in PLGA polymers can reduce the formation of acidic products, and that the catalytic degradation effect still works and causes a significantly increased degradation rate of PLGC in the later stage during this process. 22 Furthermore, during the release process of ciprofloxacin, pores were formed after the drug release, promoting the release of drugs inside the system, which in turn led to the formation of more channels, thereby increasing the porosity of the system (Figure 4). This process also increased the contact area between the carriers and the release medium and accelerated the degradation of PLGC.…”

Section: Discussionmentioning

confidence: 99%

“…PLGC was prepared as reported in our previous study. 22 Briefly, a mixture of DLLA (40 mol%), GA (40 mol%), and CL (20 mol%) was added to glass ampoules under a nitrogen atmosphere, and Sn(Oct) 2 was added to the solution in anhydrous toluene (2 × 10 −4 mol of Sn(Oct) 2 per mol of monomer). The toluene was removed by evacuation.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, it is necessary to improve the elasticity of PLGA and reduce its aciddegradation products, which may promote its application in the treatment of osteomyelitis. In our previous work, εcaprolactone (ε-CL) was introduced into either PLGA chains or poly(d, l-lactide-co-glycolide-co-ε-caprolactone) (poly(DLLA-co-GA-co-CL), abbreviated as PLGC), and PLGC was found to exhibit better elasticity and controlled degradation 22 ; hence, PLGC represents a promising carrier for biodegradable drug-delivery systems. [23][24][25] However, no studies have yet reported the use of a PLGC-based drugdelivery system for the treatment of osteomyelitis.…”

Section: Introductionmentioning

confidence: 99%

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In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

Liu

Bai

Liang

2020

Journal of Applied Biomaterials & Functional Materials

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Chronic osteomyelitis causes serious injury to patients. Antibiotic delivery systems based on poly(lactide-co-glycolide) (PLGA) have great potential for treatment of chronic osteomyelitis. However, PLGA has a glass-transition temperature that is higher than physiological temperatures, resulting in a lack of flexibility for implantation into the bone marrow cavity. As an alternative, poly(d, l-lactide-co-glycolide-co-ε-caprolactone) (PLGC) presents good flexibility due to the introduction of poly(ε-caprolactone) segments. To develop a new strategy for treatment of chronic osteomyelitis, a ciprofloxacin delivery system was prepared using PLGC as carriers, the antibacterial effects of which were evaluated both in vivo and in vitro. The in vitro release behavior showed that the average release reached 268.5 μg/days on day 33, with a cumulative release rate of 56.01%. A bacteriostatic ring, with a diameter of 26.83 ± 0.83 mm, was produced by ciprofloxacin against Staphylococcus aureus after 30 days of release via our ciprofloxacin-PLGC system. After 4 weeks of treatment in vivo, chronic-osteomyelitis-model rats had a bodyweight of 385.83 ± 17.23 g and a normal white-blood-cell count, as well as a lower number of bacterial colonies per gram of bone tissue of (10.6 ± 3.0) × 101 CFU/g. Furthermore, no inflammatory cells were observed via hematoxylin-and-eosin staining, and normal bone structure was observed via X-ray. Taken together, our findings indicate that our novel ciprofloxacin-PLGC system yielded noteworthy antibacterial effects both in vitro and in vivo, suggesting that it may be useful for treating patients with chronic osteomyelitis.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

Liu

Bai

Liang

2020

Journal of Applied Biomaterials & Functional Materials

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“…12,16 Likewise, PCL has been copolymerized with D,L-lactide and glycolide, resulting in amorphous copolymers with faster rates of degradation but with a reduction in PCL crystallinity. 18 PDLLA-PCL-PDLLA triblock copolymers degraded faster than the PCL homopolymer and exhibited a PCL T m , but % crystallinity was not quantified nor were the mechanical properties. 19 PCL has also been incorporated into blends, namely, for the purpose of enhancing the ductility and toughness of PLLA.…”

Section: ■ Introductionmentioning

confidence: 99%

PCL-Based Shape Memory Polymer Semi-IPNs: The Role of Miscibility in Tuning the Degradation Rate

et al. 2020

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The utility of poly(ε-caprolactone) (PCL) as a shape memory polymer (SMP) may be improved by accelerating its degradation. Recently, we have reported novel semi-interpenetrating networks (semi-IPNs) composed of cross-linked PCL diacrylate (PCL-DA) and thermoplastic poly(L-lactic acid) (PLLA) that exhibited SMP behavior, accelerated degradation, and enhanced moduli versus the PCL-DA control. Herein, we systematically varied the thermoplastic component of the PCLbased semi-IPNs, incorporating homo-and copolymers based on lactic acid of different M n , hydrophilicity, and crystallinity. Specifically, semicrystalline PLLAs of different M n s (7.5, 15, 30, and 120 kDa) were explored as the thermoplastics in the semi-IPNs. Additionally, to probe crystallinity and hydrophilicity, amorphous (or nearly amorphous) thermoplastics of different hydrophilicities (PDLLA and PLGAs 85:15, 70:30, and 50:50, Llactide:glycolide mole % ratio) were employed. For all semi-IPNs, the wt % ratio of the cross-linked PCL-DA to thermoplastic was 75:25. The nature of the thermoplastics was linked to semi-IPN miscibility and the trends in accelerated degradation rates.

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“…When the scaffolds that are continuously exposed to body temperature undergo degradation with thermal energy, thermally stable scaffolds (i.e., further from their melting temperature) are more slowly degraded, and also the generation rate of acid byproducts is thus lower. Thus, the slightly increased thermal stability could inhibit local inflammation and cytotoxicity, allowing acidic byproducts to gradually metabolize via the Krebs cycle. − The mechanical properties of the scaffolds were analyzed by a universal testing machine (UTM). The compressive strength of ECM-containing scaffolds tended to decrease and relatively soften as compared with PLGA scaffold without ECM proteins (Figure S4, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

Lih

Park

et al. 2019

ACS Cent. Sci.

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Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. The bioinspired scaffold was designed with poly(lactide- co -glycolide) (PLGA), magnesium hydroxide (Mg(OH) 2 ), and decellularized renal extracellular matrix (ECM). The Mg(OH) 2 inhibited materials-induced inflammatory reactions by neutralizing the acidic microenvironment formed by degradation products of PLGA, and the acellular ECM helped restore the biological function of kidney tissues. When the PLGA/ECM/Mg(OH) 2 scaffold was implanted in a partially nephrectomized mouse model, it led to the regeneration of renal glomerular tissue with a low inflammatory response. Finally, the PLGA/ECM/Mg(OH) 2 scaffold was able to restore renal function more effectively than the control groups. These results suggest that the bioinspired scaffold can be used as an advanced scaffold platform for renal disease treatment.

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Synthesis, Properties, and In Vitro Hydrolytic Degradation of Poly(d,l-lactide-co-glycolide-co-ε-caprolactone)

Cited by 9 publications

References 30 publications

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

In vitro and in vivo evaluation of a ciprofloxacin delivery system based on poly(DLLA-co-GA-co-CL) for treatment of chronic osteomyelitis

PCL-Based Shape Memory Polymer Semi-IPNs: The Role of Miscibility in Tuning the Degradation Rate

A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

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