A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

Lih, Eugene; Park, Wooram; Park, Ki Wan; Chun, So Young; Kim, Hyuncheol; Joung, Yoon Ki; Kwon, Tae Gyun; Hubbell, Jeffrey A.; Han, Dong Keun

doi:10.1021/acscentsci.8b00812

Cited by 76 publications

(61 citation statements)

References 43 publications

(92 reference statements)

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“…For instance, articles published in e Lancet Oncology have involved cellular dermal matrix in breast construction and suggested its promising value in a clinical trial [22,23]. A recent study showed the biological function of the decellularized extracellular matrix in renal tissue regeneration [24]. Acellular tissue matrix also has wide and practical applications in plastic, especially in the repair and reconstruction of bone, urethral, and vagina, due to the share of similar biological properties [7,25,26].…”

Section: Discussionmentioning

confidence: 99%

Application of Acellular Tissue Matrix for Enhancement of Weak Abdominal Wall in Animal Model

Wang

Yang

Cao

et al. 2020

BioMed Research International

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Background. Abdominal wall weakness occurs when the strength of muscle decreases due to physiological reason or iatrogenic injury. However, the treatment of this disease is complicated. Aim. To study the therapeutic effect of acellular tissue matrix (ACTM), compared with the polypropylene mesh. Methods. An abdominal wall weakness model was established in rabbits through motor nerves cutting. The polypropylene mesh and ACTM were implanted in the left and right abdomen sides, respectively. Mechanical testing of abdominal wall muscle and histology and scanning electron microscopy (SEM) evaluation of abdominal tissue explants were performed. Results. In animal model establishment, the abdominal length of healthy and weakened abdominal wall was 17.0 ± 0.7 cm and 19.0 ± 1.2 cm, respectively (P=0.022), and the weak abdominal wall group showed a significant decrease of 1.116 ± 0.221 MPa in tensile stress (P<0.001) and 9.126 ± 2.073% in tensile strain (P<0.001). In materials implantation experiment, compared with polypropylene group, ACTM group decreased 2.409 ± 0.806 MPa after 24 weeks (P<0.001) and 2.319 ± 0.486 MPa after 48 weeks (P<0.001) in tensile stress and increased 15.259% after 24 weeks (P<0.001) and 15.845% after 48 weeks (P<0.001) remarkably in tensile strain. Conclusion. The abdominal wall weakness model in rabbits was successfully established. ACTM is a promising biological material to be possibly further applied in clinical surgery in patients with abdominal wall weakness.

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Section: Discussionmentioning

confidence: 99%

Application of Acellular Tissue Matrix for Enhancement of Weak Abdominal Wall in Animal Model

Wang

Yang

Cao

et al. 2020

BioMed Research International

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“…As a result of reducing the acidity of the microenvironment, the inflammatory effect is also reduced. The ECM also improves the normal biological function of cells on the matrix [186].…”

Section: Hybrid Biomaterials Applied For Kidneysmentioning

confidence: 99%

“…Growth factors are a promising component of polymer-based hybrid materials. Hybrid materials can also be used for kidney tissue, as it is closely related to kidney regeneration in renal failure [186]. The acellular ECM could promote the normal biological function of kidney cells.…”

Section: Hybrid Biomaterials Applied For Kidneysmentioning

confidence: 99%

“…Adherence of NCI-H292 cells; tuning mechanical properties of materials [177,178,248] bFGF and AA2P based PGA/PLA Improving cells adhesion and stimulates cells proliferation and differentiation [249] Kidney (Section 6.2) Mg(OH) 2 and acellular ECM PLGA Neutralization of the effects induced by degradation of PLGA products, suppression of inflammatory reactions [186] l-DOPA and collagen IV PCL Improving cells adhesion and proliferation [250] Liver (Section 6.3) ECM-molecules PLA Microenvironment manipulation; changes of gene expression, protein contents, and cell adherence [251] PCL [252] HGF based Gelatin Controlled release for enhancement of the in vivo therapeutic effects RGD and YIGSR based PCL and PLA Improved hepatocyte adhesion [196] Cardiac muscles (Section 7.1) bFGF based PLGA Neovascular formation [253] Laminin based PU Improving cells adhesion [254] Skeletal muscles (Section 7.2)…”

Section: Gelatin Based Pcl Pgamentioning

confidence: 99%

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Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

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In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed. Pure polymer based biomaterials are predominantly used to target soft tissues. Stipulated by possibilities of tuning the composition and concentration of their inorganic content, hybrid materials allow to mimic properties of various types of harder tissues. That leads to the concept of "one-matches-all" referring to materials possessing the same polymeric base, but different inorganic content to enable tissue growth and repair, proliferation of cells, and the formation of the ECM (extra cellular matrix). Furthermore, adding drug delivery carriers to coatings and scaffolds designed with such materials brings additional functionality by encapsulating active molecules, antibacterial agents, and growth factors. We discuss here materials and methods of their assembly from a general perspective together with their applications in various tissue engineering sub-areas: interstitial, connective, vascular, nervous, visceral and musculoskeletal tissues. The overall aims of this review are two-fold: (a) to describe the needs and opportunities in the field of bio-medicine, which should be useful for material scientists, and (b) to present capabilities and resources available in the area of materials, which should be of interest for biologists and medical doctors.Polymers 2020, 12, 620 2 of 30 allows to tailor functionalize the coatings, where their responsiveness to external stimuli is one of their biggest advantages.Polymers stand out as a special class of materials due to the flexibility of design of their blocks and various functionalities, which is brought by their versatile assembly or by introducing additional side-groups or blocks, in the case of block-co-polymers. In this regard, both synthetic and biocompatible polymers are available, and polymer engineering represents a growing area tailoring the needs often driven by applications. With all advantages and the flexibility of the design, there is one significant weakness of polymers-the softness. In regard with tissue engineering, that translates to the fact that some materials can match predominantly soft tissue, but it is difficult to tune mechanical properties of polymers to match the hardness of bones, tendons, etc. And since mechanical properties of materials affect and even drive cell and tissue growth, enhancement of mechanical properties of polymers and biomaterials is essential. Chemical crosslinking can be applied to address these challenges, but that solves problems only partially.To solve these challenges the so-called hybrid materials [6] are used, which possess both inorganic and organic contents. Increasingly, hybrid materials are used in designing the extracellular matrix. The hybrid matrix design for various tissue engineering applications should meet bio-medical requirements. On the one hand, it needs to be biocompatible and biodegradable, which is achieved through the po...

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“…97,98 However, generation of acidic degradation products can decrease physiological pH and may cause an inflammatory response and fibrosis within the surrounding tissue. 99 Significant inflammation or fibrosis was not observed following placement of the antibiotic eluting stents in the in vivo animal studies, but several investigators have employed considerable efforts to reduce the inflammatory responses of PLGA by using various biological molecules and antiinflammatory drugs. 97,98,100,101 Therefore, adding an antiinflammatory agent to the PLGA material is a reasonable strategy until an ideal (nonimmunogenic, biocompatible, and biodegradable) biomaterial is available.…”

Section: The Ciprofloxacin Azithromycin Sinus Stentmentioning

confidence: 99%

Antibiotic eluting sinus stents

Thompson

Lim

Banks

et al. 2020

Laryngoscope Investig Oto

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Objectives Chronic rhinosinusitis (CRS) is a multifactorial disease affecting up to 16% of the United States population and disproportionately affecting the cystic fibrosis (CF) patient population. Despite treating the underlying infection, the use of systemic antibiotics has shown little efficacy in alleviation of symptom burden. This review seeks to discuss recent research on novel antibiotic eluting stent therapy in vitro and within animal models as well as the factors that contribute to its efficacy. Data Sources PubMed literature review. Review Methods A review of all published literature related to antibiotic eluting sinus stents was conducted to integrate and summarize this innovative approach to chronic sinus infections. Results Placement of the ciprofloxacin sinus stent (CSS) and ciprofloxacin‐ivacaftor sinus stent (CISS) exhibited improvement in endoscopic and radiographic findings in rabbit CRS models. While the CSS showed an overall trend toward improvement in microscopic findings and a reduction in biofilm mass, there remained a significant quantity of planktonic bacteria due to antibiotic depletion from an initial burst release in the first 48 hours of stent placement. The CISS and ciprofloxacin‐azithromycin sinus stents (CASSs) exhibited controlled antibiotic release over the study period leading to greatly reduced planktonic bacterial load and biofilm mass. In vitro studies indicate that CASS may be just as efficacious at reducing biofilm mass. Conclusion Antibiotic eluting sinus stents show significant promise as a novel therapeutic strategy for CRS. The CISS may have particular promise for the CF patient population by addressing both the infectious and genetic components of disease. Animal studies demonstrate significant promise for translation into human studies. Human clinical trials are warranted to determine the efficacy of antibiotic sinus stents in human patients. Level of Evidence NA

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A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration

Cited by 76 publications

References 43 publications

Application of Acellular Tissue Matrix for Enhancement of Weak Abdominal Wall in Animal Model

Application of Acellular Tissue Matrix for Enhancement of Weak Abdominal Wall in Animal Model

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

Antibiotic eluting sinus stents

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