Antibiotic Induced Diarrhoea &amp; Colitis in Orthopaedic in-Patients

Parsons, R. L.; Salfield, Jacqueline; Beavis, J. P.

doi:10.1007/978-1-4684-3123-0_43

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Postoperative Clinical Course1

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1976

1977

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“…Two patients developed pseudomembranous colitis postoperatively. This diagnosis was confirmed by sigmoidoscopy and biopsy (Parsons, Beavis & Salfield, 1976).…”

Section: Postoperative Clinical Coursementioning

confidence: 82%

Plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin during total hip replacement.

Parsons¹,

Beavis²,

Hossack³

et al. 1977

Brit J Clinical Pharma

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1 Lincomycin (600 mg) was given 6 h preoperatively by intramuscular injection, as an intravenous infusion over 30 min and for 72 h postoperatively in twelve patients having total hip replacement. 2 The plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin were almost always above the M.I.C. of lincomycin against penicillinase producing Staphylococcus aureus. 3 There was a good correlation between the estimated concentrations of lincomycin in bone by the grinding and agitation methods of analysis. 4 Two patients developed pseudomembranous colitis after parenteral lincomycin.

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“…Two patients developed pseudomembranous colitis postoperatively. This diagnosis was confirmed by sigmoidoscopy and biopsy (Parsons, Beavis & Salfield, 1976).…”

Section: Postoperative Clinical Coursementioning

confidence: 82%