Incidence of Antibiotic‐related Diarrhoea and Pseudomembranous Colitis a Prospective Study of Lincomycin, Clindamycin and Ampicillin

Clostridium Difficile infection and Antibiotic –Associated Colitis

“…Almost all antibiotic classes have been associated with the disease, reports of large clinical series' most commonly implicate clindamycin,penicillins,cephalosprins and more recently fluroquinolones [30].Several noteworthy studies primarily implicated clindamycin and ampicillin in the 1970s [31].In the most recent outbreaks associated with NAPI/027 (North American pulsed field type 1, ribotype027) which is resistant to fluoroquinolones,fluoroquinolones are clearly identified as a risk factor for clinical disease [32].Third generation cephalosporin's have been implicated in particular and seem to predispose to C.difficile-associated disease more commonly than do the narrow spectrum penicillin's or β-lactam-stable penicillin [33].A number of antineoplastic agents particularly those with modest antibacterial activity,have been associated with C.difficile diarrheal disease, including doxorubicin, cisplatin,cyclophosphamide and others [34 ].…”