Healthcare‐associated Infections: Epidemiology, Prevention, and Therapy

Abstract

Reducing nosocomial infection rates is a major component of healthcare improvement. This article reviews the epidemiology, prevention, and therapy for some of the most common healthcare-associated infections, including central line-associated bloodstream infections and catheter-associated urinary tract infections, and 3 common organisms: methicillin-resistant Staphylococcus aureus, multidrug- resistant gram-negative bacteria, and Clostridium difficile.

Trending 7 years of in vitro activity of tigecycline and comparators against Gram-positive and Gram-negative pathogens from the Asia-Pacific region: Tigecycline Evaluation Surveillance Trial (TEST) 2004–2010

“…Gram-negative bacilli continue to be an important cause of healthcare-associated infections [6][7][8] and antimicrobial resistance amongst these bacilli is increasing on a worldwide basis [2,4]. Worldwide resistance in Gram-positive cocci is also rising dramatically [9], with even antibiotics such as vancomycin now associated with the phenomenon of vancomycin-reducedsusceptible status [10].…”

“…Antimicrobial resistance amongst microorganisms is steadily increasing worldwide, and countries in the Asia-Pacific region are especially known to have high rates of antimicrobial resistance [1][2][3][4][5]. Gram-negative bacilli continue to be an important cause of healthcare-associated infections [6][7][8] and antimicrobial resistance amongst these bacilli is increasing on a worldwide basis [2,4].…”

Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole

“…ade, there has been a striking increase in the prevalence of hospital-acquired MRSA infections as well as an emergent epidemic of community-acquired MRSA infections (4). Most disconcerting is the development of resistance in S. aureus to current last-resort antibiotics including vancomycin (5) and linezolid (6).…”

Emergence of High Levels of Extended-Spectrum-β-Lactamase-Producing Gram-Negative Bacilli in the Asia-Pacific Region: Data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) Program, 2007

“…Gram-negative bacilli (GNB) continue to be an important cause of health care-associated infections (8,15). They are a common cause of sepsis, pneumonia, urinary tract infection, postsurgical infections in acute care hospitals, and intra-abdominal infections (16).…”