Lincomycin Bone Concentrations During Total Hip Replacement

Parsons, R. L.; Beavis, J. P.; Paddock, Gillian M.; Hossack, G. M.

doi:10.1007/978-1-4613-4346-2_30

Cited by 3 publications

(1 citation statement)

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“…Although prophylactic antibiotic therapy now has an established place in clean orthopaedic surgery (Fitzgerald et al, 1973), the incidence of therapeutic complications has not so far been evaluated in this group. Orthopaedic patients require effective therapy with antistaphylococcal antibiotics such as lincomycin and clindamycin that penetrate bone (Parsons, Beavis et al, 1975). Thus, since staphylococcal and other infections may complicate hip replacement (Fitzgerald et al, 1973), these antibiotics are morelikely to be used in this group.…”

Section: Discussionmentioning

confidence: 99%

Colitis and diarrhoea: A problem with antibiotic therapy

Beavis

Parsons

Salfield

1976

Journal of British Surgery

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During a 19-month study the incidence of diarrhoea and colitis was estimated in 1158 orthopaedic inpatients admitted to the Guy's group of hospitals. The highest incidence of diarrhoea followed the use of lincomycin (22.2 per cent), ampicillin with cloxacillin (17.2 per cent), clindamycin (15.3 per cent) and combined therapy with cloxacillin and tetracycline (12.5 per cent). There were 3 documented cases of colitis; 2 followed lincomycin and 1 clindamycin. The incidence and relationship of antibiotic-related diarrhoea and colitis to possible aetiological factors are discussed. In orthopaedic inpatients, in whom lincomycin and clindamycin are often the antibiotics of choice, their continued use appears to be fully justified by the low incidence of colitis. However, if a patient receiving treatment with either of these antibiotics does develop diarrhoea, the antibiotic should be discontinued immediately, to reduce the risk of subsequent colitis.

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Section: Discussionmentioning

confidence: 99%