Antibiofilm Effects of Endodontic Sealers Containing Quaternary Ammonium Polyethylenimine Nanoparticles

Barros, Joana; Silva, Marlei G.; Rôças, Isabela N.; Gonçalves, Lúcio Souza; Alves, Flávio F.; Lopes, M. A.; Pina‐Vaz, Irene; Siqueira, José F.

doi:10.1016/j.joen.2013.12.021

Cited by 51 publications

(52 citation statements)

References 33 publications

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“…j o u r n a l o f d e n t i s t r y x x x ( 2 0 1 5 ) x x x -x x x the sealer itself 12,19,26 and also to the normal physiology of the biofilm which is a dynamic structure where bacteria follow their vital cycle. However, the addition of BC conferred antibacterial properties as can be observed by both tests and this activity was concentration-dependant from 2%.…”

Section: Discussionmentioning

confidence: 99%

The effect of benzalkonium chloride additions to AH Plus sealer. Antimicrobial, physical and chemical properties

Arias-Moliz

Ruiz-Linares

Cassar

et al. 2015

Journal of Dentistry

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Section: Discussionmentioning

confidence: 99%

The effect of benzalkonium chloride additions to AH Plus sealer. Antimicrobial, physical and chemical properties

Arias-Moliz

Ruiz-Linares

Cassar

et al. 2015

Journal of Dentistry

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“…Because of the small size and large surface area of the nanoparticles, as well as their capability to release high concentrations of ions with low filler content, only a small amount is required for incorporation into dental materials. Incorporation of low concentration of these nanoparticles (1-2 wt%) into dental materials [229,230,282,284,327] provides potent and broadspectrum antimicrobial effects. Silane-quaternary amine-based antimicrobials, generally consisting of an organic shell with antimicrobial functionality and a silica core with high colloidal stability, have been shown to be effective antimicrobial fillers for more than 40 years [328].…”

Section: Dental Materialsmentioning

confidence: 99%

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Jiao

Niu

et al. 2017

Progress in Polymer Science

473

317

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a b s t r a c tMicrobial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.Published by Elsevier B.V.

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“…aminopropyltrimethoxysilane, (AHAP3) because MAP3 releases NO more rapidly than AHAP3. 140 Similarly, composite of amorphous calcium phosphate and quaternary ammonium monomer inhibited the biofilms and also promoted the remineralisation of the teeth. 136,137 Calcium hydroxide and chitosan NPs are efflux pump inhibitors and also inhibit biofilms.…”

Section: Antibiofilm Efficacy Of Natural Compound Based Metal Nano-bimentioning

confidence: 99%

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

2016

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Microbes form surface adherent community structures called biofilms and these biofilms play a critical role in infection. Biofilms impart antibiotic resistance and sometimes become recalcitrant to host immune system. It has reported by the National Institutes of Health that more than 80% of the bacterial infections caused by biofilms formation. Such kind of infection is also prevalent in biomedical devices which becomes a source of infection.The treatment of biofilm mediated infections is a big challenge that requires more sensitive and effective antibiofilm strategies for their removal. Nanoparticles targeted antibiofilm therapy has gained tremendous impetus in last decade due to their unique features. These are wonder particles having a wide spectrum biological applications and among these there antibiofilm activity is significantly useful. These particles are reactive entities and can easily infiltrate into the matrix which acts as a barrier for many antibiotics. Biomedical surfaces are also nano-functionalized by coating, impregnation or embedding nanomaterials to prevent biofilm formation. The study of interaction between nanoparticles and biofilm can provide us more insights about the mechanism of biofilm regulation. In this review article several classes of NPs effective against a broad range of microbial biofilms, both in vivo and in vitro are described. The application of nanoparticles against biofilm will help to fight resistant infections and will share its role in improving human health in the future.

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Antibiofilm Effects of Endodontic Sealers Containing Quaternary Ammonium Polyethylenimine Nanoparticles

Cited by 51 publications

References 33 publications

The effect of benzalkonium chloride additions to AH Plus sealer. Antimicrobial, physical and chemical properties

The effect of benzalkonium chloride additions to AH Plus sealer. Antimicrobial, physical and chemical properties

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance

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