Antibacterial Pterocarpans from Erythrina subumbrans

Rukachaisirikul, Thitima; Innok, Phongsak; Aroonrerk, Nuntana; Boonamnuaylap, Woraluk; Limrangsun, Saranya; Boonyon, Chanakan; Woonjina, Umpawan; Suksamrarn, Apichart

doi:10.1016/j.jep.2006.09.022

Cited by 61 publications

(36 citation statements)

References 31 publications

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“…Compounds 71 and 73 exhibited the highest degree of activity against Streptococcus strains with MICs in range of 0.78-1.56 μg/mL, whereas compound 73 not only exhibited the highest degree of activity against Staphylococcus strains, but also showed anti-MRSA activity, with MICs in range of 0.39-1.56 μg/mL. [38] Two new oxygen heterocyclic Diels-Alder-type adducts, sorocenols G (74) and H (75), isolated and identified from a root extract of Sorocea muriculata using bioassay-guided method showed significant and selective activity against MRSA with IC50 values of 1.5 and 0.5 µM, respectively. [39] Bioassay guided fractionation and purification of the extract from Hypericum riparium leaves resulted in the isolation of compounds chipericumin E (76) and hypercalin C (77), which showed significant antimicrobial potential (6.54 μg/mL ≤ IC50 ≤ 16.90 μg/mL) against MRSA (Figure 8).…”

Section: Phenolicsmentioning

confidence: 95%

“…[22] Caesalfurfuric acid A (35), one isopimarane diterpene, isolated from the twigs of Caesalpinia furfuracea, was found to exhibit moderate antibacterial activity against MRSA SK1 with the MIC value of 16 μg/mL. [23] Bioassay guided isolation of the ethyl acetate fraction of Siegesbeckia orientalis led to the isolation of ent-kaurane diterpenoids, 16β-hydro-ent-kauran-17,19-dioic acid (36), 16α,17-dihydroxy-ent-kauran-19-oic acid (37), 16β,17,18-trihydroxy-ent-kauran-19-oic acid (38), and 17,18-dihydroxy-ent-kauran-19-oic acid (39), which all exhibited the anti-MRSA activity with MIC valuses of in the range of 0.05-0.50 mg/mL. [24] Two abietane diterpenes compounds, 2β-ace toxyferruginol (40) and ferruginol (41), isolated from the stem bark of Prumnopitys andina also exhibited antibacterial activity at 8 μg/mL against two effluxing strains of S. aureus.…”

Section: Alkaloidsmentioning

confidence: 99%

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Recent Advances on anti-MRSA Natural Products Derived from Plants

Guo¹,

Su²,

Tian-fang³

et al. 2018

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Methicillin-resistant Staphylococcus aureus (MRSA) is a multi-drug resistant pathogenic bacteria, which has seriously threatened human health for a long time. Therefore, there is an urgent and unmet demand for new types of antibiotics. In response to the antibiotic resistance, many researchers have studied natural products derived from plant for alternative antibiotics and therapies. In this review, we summarized recent advances on anti-MRSA natural products from plants and their potential antibacterial effect against MRSA as potential anti-MRSA agents since 2007.

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Section: Phenolicsmentioning

confidence: 95%

Section: Alkaloidsmentioning

confidence: 99%

Recent Advances on anti-MRSA Natural Products Derived from Plants

Guo¹,

Su²,

Tian-fang³

et al. 2018

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“…Isoflavoneare subclass of flavonoids which are found in fruits, nuts, soybeans, and soybased products [1]. Isoflavones have demonstrated a variety of important biological activities, including antioxidant [2], antibacterial [3], osteoporosis [4], anticancer effects [1]- [5]. The biological activity of these compounds is associated with beneficial effects on human health has become an interesting topic in the study of isoflavones including synthetic methods.…”

Section: Introductionmentioning

confidence: 99%

Synthesis 3,4-Dimethoxybenzyl-2,4-Dihydroxyphenyl Ketone from Eugenol

Matsjeh¹,

Anwar²,

N³

et al. 2015

IJCEA

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Abstract-The main content of clove oil is eugenol, amounting to 80-90%. The aims this study to utilize eugenol from clove leave oil as raw material in the synthesis of 3,4-dimethoxybenzyl-2',4'-dihydroxyphenyl ketone with 3,4-dimethoxybenzylcyanide as intermediate compound. Converting eugenol into 3, 4-dimethoxybenzyl cyanide via several stages of reactions. Methylation of eugenol using dimethylsulphate and NaOH as catalyst was produced methyleugenol as much as 89.78% with a purity of 93.6%. Isomerization of methyleugenol using alkaline potassium tertiary butoxide (t-BuOK) in the medium dimethyl sulfoxide (DMSO) was resulted in 87.24 % yield methylisoeugenol with a purity of 88.89%. Methylisoeugenol was oxydated using potassium dichromate (K 2 Cr 2 O 7 ) in a phase transfer catalyst system (PTC) by Polysorbate 80 into a 3,4-dimethoxybenzaldehyde as much as 85.36 % with a purity 83.46 %. Reduction of 3.4-dimethoxybenzaldehyde using sodium borohidrat (NaBH 4 ) was producted 3.4-dimethoxybenzylalcohol as much as 98 % with a purity 100 % level. The 3.4-dimethoxybenzylalcohol was halogenated using SOCl 2 was producted 3.4-dimethoxybenzylchloride which reacted further with sodium cyanide to produce 3.4-dimethoxybenzylcyanide as much as 89.5 % with a purity 99.24%.The acylation reaction of acid 3,4-dimethoxyphenylacetic acid with resorcinol to 3,4-dimethoxybenzyl-2,4-dihydroxyphenyl ketone obtained is a white a solid product having a melting point of 171-172 O C. Rendamen generated from this experiment by 76%. IndexTerms-Eugenol, 3.4-dimethoxybenzylcyanide, 3,4-dimethoxybenzyl-2', 4'dihydroxyphenylketone.

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“…Isoflavones have demonstrated a variety of important biological activities, including antioxidant [2], antibacterial [3], osteoporosis [4] and anticancer activities [5]. The biological activities of these compounds that related to those beneficial effects in human health had become the interest topic in isoflavones research including synthetic method.…”

Section: Introductionmentioning

confidence: 99%