Antibacterial properties and compressive strength of new one-step preparation silver nanoparticles in glass ionomer cements (NanoAg-GIC)

Paiva, Lilian Fernanda Santos; Fidalgo, Tatiana Kelly da Silva; Costa, Luiz Pereira da; Maia, Lucianne Cople; Balan, Lavinia; Anselme, Karine; Ploux, Lydie; Thiré, Rossana Mara da Silva Moreira

doi:10.1016/j.jdent.2017.12.003

Cited by 92 publications

(64 citation statements)

References 54 publications

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“…However, concentrations of fluoride released from GICs are too low to effectively inhibit the growth of oral bacteria [7][8][9] . Therefore, several attempts have been made to provide GICs with antibacterial effects by adding antimicrobial components such as chlorhexidine [10][11][12] , quaternary ammonium compounds 13) , silver nanoparticles 14) , epigallocatechin-3-gallateor 15) , and propolis extract 16) .…”

Section: Introductionmentioning

confidence: 99%

Acidity-induced release of zinc ion from BioUnionTM filler and its inhibitory effects against Streptococcus mutans

et al. 2020

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BioUnion filler incorporated into restorative/coating materials is a new bio-functional glass powder. The most unique function of BioUnion filler is its ability to release Zn 2+ in acidic environments. In this study, the ion release profile of BioUnion filler under acidic conditions and its antibacterial effects against Streptococcus mutans were evaluated. The concentrations of Zn 2+ released from BioUnion fillers into acetic acids were greater than those released into water. S. mutans inhibition by BioUnion fillers was greater with sucrose than without sucrose, reflecting a decrease in suspension pH in response to the addition of sucrose. Exposure to acids increased Zn 2+ release from BioUnion fillers, and the fillers after repeated exposure to acids demonstrated inhibitory effects against S. mutans. These findings suggest that BioUnion filler accelerated the release of Zn 2+ under acidic conditions, which induced bactericidal/inhibitory effects against S. mutans.

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Section: Introductionmentioning

confidence: 99%

Acidity-induced release of zinc ion from BioUnionTM filler and its inhibitory effects against Streptococcus mutans

et al. 2020

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“…For example, nanoglasses, chlorhexidine, chitosan, and metallic nanoparticles have been applied as antibacterial and antifungal additives [10]. Corresponding in vitro or in vivo trials showed differing effectiveness of these modifications, but none of these antimicrobial alterations has prevailed over the others or is actually widely used in dentistry [11][12][13][14][15]. The luting materials tested in the present study are zinc oxide phosphate cements (ZOP), representing the most common conventional luting material in dentistry [1].…”

Section: Introductionmentioning

confidence: 96%

The antimicrobial and cytotoxic effects of a copper-loaded zinc oxide phosphate cement

Wassmann¹,

Schubert²,

Malinski³

et al. 2020

Clin Oral Invest

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Objectives Evidence about modifications of dental luting materials to minimize biological failure at the "marginal gap" between teeth and fixed prosthodontics is scarce. We compared a copper-modified (Co-ZOP) and a conventional zinc oxide phosphate cement (ZOP) in terms of antimicrobial and cytotoxic potentials in vitro and in vivo. Materials and methods Specimens of ZOP and Co-ZOP were characterized by the mean arithmetic roughness (Ra) and surface free energy (SFE). Powder components were examined using scanning electron microscopy (SEM). Energy-dispersive X-ray spectroscopy (EDX) showed elemental material compositions. In vitro microbial adhesion was shown using SEM, luminescence, and fluorescence assays. CCK-8 assays of mouse fibroblasts (L929) and human gingival fibroblasts (GF-1) were performed after 6, 24, and 48 h of specimen incubation. In vivo, ZOP and Co-ZOP specimens were applied intraorally for 12 h; biofilm accumulation was shown using SEM. Results Ra of ZOP and Co-ZOP showed no significant differences; SFE was significantly higher for Co-ZOP. EDX exhibited minor copper radiation for Co-ZOP, none for ZOP. In vitro fungal adhesion to Co-ZOP was significantly higher than to ZOP; in vitro streptococcal adhesion, cytotoxicity, and in vivo biofilm formation were not significantly different. Conclusions Co-ZOP showed low surface allocations of copper with no improved antimicrobial properties compared with conventional ZOP in vitro or in vivo. Clinical relevance Antimicrobial effects and low cytotoxicity of biomaterials are important for the clinical outcome. Based on our in vitro and in vivo results, no clinical recommendation can be given for the tested Co-ZOP.

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“…Studies have shown, AgNPs synergize the e cacy of antibiotics like amoxicillin, clindamycin, vancomycin and penicillin G against various microbes [13,14]. Because of its antimicrobial activity and synergizing effects, researchers have studied the use of AgNPs in several areas of dentistry which include dental biomaterials [15][16][17], dental implants [18], orthodontic adhesives [19] etc. In vitro studies have shown, addition of AgNPs in to dental restorative materials inhibit growth of common oral microbes like Streptococcusmutans, Streptococcus sanguinis,and Lactobacillus through bactericidal and bacteriostatic effects of AgNPs on oral microbes [16,20] without altering its mechanical properties [21].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and application of silver nano-biotics for enhancing the antimicrobial activity of glass-ionomer cement against studied microorganisms and its effect on compressive strength

Enan

Ashour

Basha

et al. 2020

Preprint

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Background. The development of dental caries is associated with various microorganisms and secondary caries formation is the main cause of restorations failure. The advise for restorative dental materials that have antimicrobial properties has stimulated the introduction of materials containing different antibacterial agents.Objectives: Present study has been designed to synthesize silver nanoparticles (AgNPs) and incorporate AgNPs and amoxicillin into glass ionomer cement (GIC) to synergize its effect on oral microbes. The effect of the added antimicrobial agents on compressive strength (CS) of GIC was also evaluated.Material and methods: Biosynthesis of AgNPs were done using Cupressus macrocarpa extract and AgNPs were charectatrized. A total of 120 disc-shaped specimens were prepared and classified into 4 main groups where Group A include conventional GIC, Groups B and C include GIC with AgNPs or Amoxicillin, respectively, while Group D included GIC with both AgNPs and Amoxicillin. Each group was tested for the antimicrobial activity against both Streptococcus mutans (S. mutans) and Staphylococcus aureus (S. aureus). The distribution of biofilm was examined via scanning electron microscope. The CS of the tested material was measured using a Material Test System(MTS).Results: UV-Visible spectrum showed a peak of 429 nm. TEM, XRD pattern and FTIR analysis confirmed the formation of AgNPs with spherical to oblong polydispersed particles of diameter in the range of 13.5-25.8 nm. The maximum inhibitory zone was recorded for group D against both tested bacteria with a mean of 29 mm at first 24-hour period to 15 mm at three weeks and showed antimicrobial rate 92.2% and 92.56%, against both strains, respectively. Additionally, group D disintegrated the structure of S. aureus biofilm and even kill bacteria in the biofilms. Addition of AgNPs and Amoxicillin caused an insignificant effect on CS of GIC.Conclusion: TheAgNPs showed a synergistic effect in combination with amoxicillin and GIC dental restorative material against studied microorganisms. The agents can be safely added with minimal effect on mechanical properties of the original cement.

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Antibacterial properties and compressive strength of new one-step preparation silver nanoparticles in glass ionomer cements (NanoAg-GIC)

Abstract: Silver nanoparticles one-step preparation in polyacrylate solution allowed the production of highly bioactive water-based cements within suitable parameters for clinical use and with large potential of dental and biomedical application.

Cited by 92 publications

References 54 publications

Acidity-induced release of zinc ion from BioUnion<sup>TM</sup> filler and its inhibitory effects against <i>Streptococcus mutans </i>

Acidity-induced release of zinc ion from BioUnion<sup>TM</sup> filler and its inhibitory effects against <i>Streptococcus mutans </i>

The antimicrobial and cytotoxic effects of a copper-loaded zinc oxide phosphate cement

Biosynthesis and application of silver nano-biotics for enhancing the antimicrobial activity of glass-ionomer cement against studied microorganisms and its effect on compressive strength

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