Antibacterial potential of Thevetia peruviana leaf extracts against food associated bacterial pathogens

doi:10.12980/jclm.3.201514j86

JCLM

2015

DOI: 10.12980/jclm.3.201514j86

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Antibacterial potential of Thevetia peruviana leaf extracts against food associated bacterial pathogens

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Cited by 4 publications

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In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts ofLantana camaraLeaves Collected from Tropical Region of Malaysia

Swamy

Sinniah

Akhtar

2015

Evidence-Based Complementary and Alternative Medicine

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We investigated the effect of different solvents (ethyl acetate, methanol, acetone, and chloroform) on the extraction of phytoconstituents from Lantana camara leaves and their antioxidant and antibacterial activities. Further, GC-MS analysis was carried out to identify the bioactive chemical constituents occurring in the active extract. The results revealed the presence of various phytocompounds in the extracts. The methanol solvent recovered higher extractable compounds (14.4% of yield) and contained the highest phenolic (92.8 mg GAE/g) and flavonoid (26.5 mg RE/g) content. DPPH radical scavenging assay showed the IC50 value of 165, 200, 245, and 440 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively. The hydroxyl scavenging activity test showed the IC50 value of 110, 240, 300, and 510 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively. Gram negative bacterial pathogens (E. coli and K. pneumoniae) were more susceptible to all extracts compared to Gram positive bacteria (M. luteus, B. subtilis, and S. aureus). Methanol extract had the highest inhibition activity against all the tested microbes. Moreover, methanolic extract of L. camara contained 32 bioactive components as revealed by GC-MS study. The identified major compounds included hexadecanoic acid (5.197%), phytol (4.528%), caryophyllene oxide (4.605%), and 9,12,15-octadecatrienoic acid, methyl ester, (Z,Z,Z)- (3.751%).

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In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts ofLantana camaraLeaves Collected from Tropical Region of Malaysia

Swamy

Sinniah

Akhtar

2015

Evidence-Based Complementary and Alternative Medicine

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Anticancer Properties of Different Solvent Extracts of Cucumis melo L. Seeds and Whole Fruit and Their Metabolite Profiling Using HPLC and GC-MS

Zhang

Bai

Wang

et al. 2020

BioMed Research International

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Honeydew melon (Cucumis melo L.) is an oval-shaped delicious fruit of one cultivar group of the muskmelon with immense nutritional importance and is extensively consumed by many tropical countries. The effect of various organic solvents on the recovery of phytochemicals from honeydew melon plant fruits and seeds was assessed. Further, High-Performance Liquid Chromatography (HPLC) was used to examine and assess the contents of phenolic acid (gallic acid) and flavonoid (rutin) compounds. The use of gas chromatography–mass spectrometry (GC-MS) analysis explained the presence of volatile phytocompounds in the extracts. The use of organic solvents had a substantial impact on the total dry weight and extract yield. In general, the solvent-extracted constituents remained in the order of methanol>chloroform>distilled water for both honeydew melon seeds and whole fruit. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) was used to assess the cytotoxicity effect against PC3, HCT116, HeLa, and Jurkat cell lines. The chloroform extract exhibited a good cytotoxic activity against all cell lines as compared to other solvent extracts. HPLC analysis revealed the occurrence of gallic acid content of 0.102±0.23 mg/10 mg of dry whole fruit extract, while 10 mg of dry seed extract contained only 0.022±0.12 mg of gallic acid content. Likewise, rutin content was observed to be 0.224±0.31 mg and 0.1916±0.82 mg/10 mg of dry whole fruit and seed extract, respectively. Further, GC-MS analysis revealed the presence of a total of 37 compounds in chloroform extract of whole fruit, while only 14 compounds were found in seed extract. Nevertheless, more examinations are needed to identify and characterize other metabolites from honeydew melon and evaluate their pharmacological importance.

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In vivo hypoglycemic, antinociceptive and in vitro antioxidant activities of methanolic bark extract of Crataeva nurvala

Uddin¹,

Karim²,

Dwigbijoy³

et al. 2017

JCLM

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Antibacterial potential of Thevetia peruviana leaf extracts against food associated bacterial pathogens

Cited by 4 publications

References 20 publications

In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts ofLantana camaraLeaves Collected from Tropical Region of Malaysia

In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts ofLantana camaraLeaves Collected from Tropical Region of Malaysia

Anticancer Properties of Different Solvent Extracts of Cucumis melo L. Seeds and Whole Fruit and Their Metabolite Profiling Using HPLC and GC-MS

In vivo hypoglycemic, antinociceptive and in vitro antioxidant activities of methanolic bark extract of Crataeva nurvala

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