Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects

Mai, Hang‐Nga; Hyun, Dong Choon; Park, Ju Hayng; Kim, Do-Yeon; Lee, Sang Min; Lee, Du‐Hyeong

doi:10.3390/ph13100304

Cited by 24 publications

(18 citation statements)

References 46 publications

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“…The product reduced friction by two orders of magnitude in an aqueous environment, which had a friction coefficient (µ) as low as 0.003 [ 65 ]. A chlorhexidine (CHX)-loaded PDMS-based coating was applied on the surface of a 3D-printed dental polymer to induce surface wettability, microstructure, and antibacterial activity [ 66 ]. CHX was encapsulated in silica nanoparticles and added to PDMS to produce an antibacterial coating material.…”

Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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“…The particular use of polymeric coatings relies on their intrinsic features, including bioavailability and application-related tunable properties, versatile surface chemistry and solubility/dissolution, biodegradability and biocompatibility and genuine biological and therapeutic activity [11,12]. Moreover, by properly tuning their composition and microstructure, such coatings possess the ability to act as protective and bioactive matrices for therapeutic substances and to concurrently facilitate controlled and targeted local effects and diminish or eliminate collateral or side effects [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

et al. 2021

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To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings.

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“…In these treatments, 3D-printed polymers, such as polylactic acid, are fabricated and implanted in an oral cavity since they are resistant against impact and are non-toxic [ 104 ]. 3D-printed polymers also have little surface roughness, which is beneficial since surface roughness promotes biofilm formation that attracts harmful bacteria to the implant [ 105 ]. Figure 5 B demonstrates a polymer dental cast using polyjet printing from a study that compared 3D-printed dental casts to those made of dental stone; the 3D-printed cases were investigated with multiple printing processes and materials [ 96 ].…”

Section: Medical Applicationsmentioning

confidence: 99%

Polymer 3D Printing Review: Materials, Process, and Design Strategies for Medical Applications

et al. 2021

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Polymer 3D printing is an emerging technology with recent research translating towards increased use in industry, particularly in medical fields. Polymer printing is advantageous because it enables printing low-cost functional parts with diverse properties and capabilities. Here, we provide a review of recent research advances for polymer 3D printing by investigating research related to materials, processes, and design strategies for medical applications. Research in materials has led to the development of polymers with advantageous characteristics for mechanics and biocompatibility, with tuning of mechanical properties achieved by altering printing process parameters. Suitable polymer printing processes include extrusion, resin, and powder 3D printing, which enable directed material deposition for the design of advantageous and customized architectures. Design strategies, such as hierarchical distribution of materials, enable balancing of conflicting properties, such as mechanical and biological needs for tissue scaffolds. Further medical applications reviewed include safety equipment, dental implants, and drug delivery systems, with findings suggesting a need for improved design methods to navigate the complex decision space enabled by 3D printing. Further research across these areas will lead to continued improvement of 3D-printed design performance that is essential for advancing frontiers across engineering and medicine.

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Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects

Cited by 24 publications

References 46 publications

Biopolymer Coatings for Biomedical Applications

Biopolymer Coatings for Biomedical Applications

Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices

Polymer 3D Printing Review: Materials, Process, and Design Strategies for Medical Applications

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