Antibacterial, antifungal and antiviral activity of propolis of different geographic origin

Kujumgiev, A; Tsvetkova, Iva; Serkedjieva, Yu; Bankova, Vassya; Christov, R.; Попов, Симеон

doi:10.1016/s0378-8741(98)00131-7

Cited by 891 publications

(696 citation statements)

References 16 publications

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“…However, percentage of yield, antioxidant activity, total phenolic and flavonoid compound content in propolis from Phayao province was lower than the study by Trusheva et al (2007). These may due to the difference of propolis source and active component of propolis as different geographic property affects chemical composition and biological activity of propolis (Kujumgiev et al, 1999). Propolis form Europe and China had high flavonoid and phenolic contens (Bankova et al, 2000).…”

Section: Discussionmentioning

confidence: 74%

“…Candida albicans, C. tropicalis, Tenia versicolor and Aspergillus flavus were also inhibited by propolis. Moreover propolis inhibited viruses including avian influenza virus and herpes simplex virus type 1 (Amoros et al, 1994;Kujumgiev et al, 1999;Uzel et al, DOI:http://dx.doi.org/10.7314/APJCP.2013.14.11.6991 Antioxidant and Anti-cancer The extraction of propolis using maceration and sonication affected biological properties of propolis especially antioxidant activity, antiproliferative activity, total phenolic and flavonoid compound contents. These two methods gave the different active compounds.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and Anti-cancer Cell Proliferation Activity of Propolis Extracts from Two Extraction Methods

Khacha-ananda¹,

Tragoolpua²,

Chantawannakul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-cancer Cell Proliferation Activity of Propolis Extracts from Two Extraction Methods

Khacha-ananda¹,

Tragoolpua²,

Chantawannakul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The antimicrobial property of propolis has been attributed mainly to flavonoids (Greenaway, Scaysbrook, Whatley, 1990;Viuda-Martos et al 2008). However, Kujumgiev et al (1999) have shown that propolis antimicrobial activity results from the synergy between its own components. In this study, the authors have analyzed both the chemical composition and antimicrobial activity from extracts collected in different world regions, including tropical as well as temperate areas.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have examined propolis antimicrobial activity using serial dilution tests (Sonmez et al, 2005;Victorino et al, 2007) and diffusion tests on agar (Kujumgiev et al, 1999;Somnes et al,. 2005;Bruschi et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…In the scientific community, propolis has demonstrated antibacterial (Wuyuan, Green, Birch , 1990;Grange, Davey, 1990;Santos et al, 2002;Koru et al, 2007), antifungal (Kujumgiev et al, 1999;Quintero-Mora et al, 2008), anti-inflammatory (Dobrowolski et al, 1991;Hu et al, 2005;Sosa, 2007), cicatrizant (Perri de Carvalho, Tagliavini, Tagliavini, 1991) and immunomodulator (Dimov et al, 1992;Simões et al, 2004) action.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of propolis-based toothpastes for endodontic treatment

Victorino

Bramante

Watanabe

et al. 2009

Braz. J. Pharm. Sci.

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This study evaluated the antibacterial activity of propolis-based toothpastes used as intracanal medication in endodontic treatment. The propolis-based toothpastes were prepared using an extract established in previous studies (identified as A70D and D70D). Calcium hydroxide paste was used as a control. The diffusion-well method on double-layer agar was used in a culture medium of Tryptic Soy Agar. The plates were kept at room temperature for two hours to allow the diffusion of pastes in the culture medium, and then incubated at 35º C for twenty-four hours in aerobiosis and in microaerophilia (S. mutans). After this period, the total diameter of the inhibition halo was measured. The results were analyzed by ANOVA analysis of variance, followed by the Tukey test at p<0.05. The propolis-based toothpastes presented antibacterial activity against 83.3% of the analyzed bacteria. For 66.7% of these bacteria, the propolis-based toothpastes exhibited greater antibacterial activity than calcium hydroxide. The present results allow us to conclude that the experimental pastes A70D and D70D showed good activity against aerobic bacteria, proving more effective than calcium hydroxide.Uniterms: Propolis/antibacterial activity. Tooth paste/with propolis/antibacterial activity. Endodontics/ treatment.O objetivo deste estudo foi avaliar a atividade antibacteriana de formas farmacêuticas a base de própolis para uso no tratamento endodôntico como medicação intracanal. As formulações de própolis, em forma de pastas, foram preparadas a partir de um extrato pré-estabelecido em estudos anteriores e identificadas como A70D e D70D. Como controle, foi utilizado pasta de hidróxido de cálcio. (26.5 -coagulase negativa) e Staphylococcus epidermidis (6epi). Foi utilizado o método poço difusão em camada dupla de ágar, em meio de cultura Tryptic Soy Agar. As placas foram mantidas à temperatura ambiente por 2 h para permitir a difusão das pastas no meio de cultura, e então incubadas a 35 ºC por 24 h em aerobiose e em microaerofilia (S. mutans). Após este período, foi medido o diâmetro total do halo de inibição. Os resultados foram submetidos ao teste de análise de variância ANOVA seguido do teste de Tukey com p<0,05. As pastas a base de própolis apresentaram atividade antibacteriana contra 83,3% das bactérias analisadas. Para 66,7% das bactérias, as pastas de própolis apresentaram maior atividade

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