Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives

Abstract

Various 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives were conceived. The title compounds demonstrated striking inhibitory effects against Xac, Psa, and Xoo. EC 50 data exhibited that A8 (19.7 μg/mL) had better antibacterial activity against Xoo than myricetin, BT, and TC. Simultaneously, the mechanism of action of A8 had been verified by SEM. The results of anti-tobacco mosaic virus indicated that A9 had the best in vivo antiviral effect compared with ningnanmycin. From the data of MST, it could be seen that A9 (0.003 ± 0.001 μmol/L) exhibited a strong binding capacity, which was far superior to ningnanmycin (2.726 ± 1.301 μmol/L). This study shows that the 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives may become agricultural drugs with great potential.

Design, Synthesis, Antibacterial Activity, Antiviral Activity, and Mechanism of Myricetin Derivatives Containing a Quinazolinone Moiety

“…Molecular docking study was obtained using DS-CDoking implemented in Discovery Studio (version 4.5). Compound L11 was selected for docking with TMV-CP (PDB code: 1EI7) …”

“…Compound L11 was selected for docking with TMV-CP (PDB code: 1EI7). 36 ■ ASSOCIATED CONTENT * sı Supporting Information…”

Synthesis of Diaryl Sulfides by Using Tetramethylthiuram Monosulfide (TMTM) as Organosulfur Source: A Practical C(sp2)−S Bond Construction

“…As a special structure in natural products, [1] medicinal chemistry, [2] and material chemistry, [3] organic sulfides endow organic molecules with different activities. [4] They are interspersed in various structural frameworks and become the key factors of pharmaceutical activities. [5] For example, A is a potential therapeutic compound targeting the zinc finger of HIV-1 nucleocapsid (Figure 1A).…”

Design, synthesis and biological activities of echinopsine derivatives containing acylhydrazone moiety

“…found some β-carboline analogues 7 , hemigossypol 13 , dehydrobufotenine derivatives 14 , pityriacitrin marine alkaloids 15 , pulmonarin alkaloids 16 and hamacanthin derivatives 17 exhibited higher anti-TMV activities than ningnanmycin. Many other natural alkaloids derivatives were also developed as potential TMV inhibitors 18 – 27 . Although a variety of natural product derivatives have been found to exhibit high anti-TMV activity, few of them have been applied successfully in agriculture.…”