Antibacterial and antifungal activity of Xylopia aethiopica, Monodora myristica, Zanthoxylum xanthoxyloı̈des and Zanthoxylum leprieurii from Cameroon

Tatsadjieu, Léopold Ngoune; Ngang, Jean Justin Essia; Ngassoum, Martin Benoît; Etoa, F. X.

doi:10.1016/s0367-326x(03)00067-4

Cited by 117 publications

(76 citation statements)

References 6 publications

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“…In traditional Cameroon medicine, this plant is used for the treatment of intestinal worms, abdominal pain, hyperhermia, diarrhea and certain mycosis [12]. Previous works have demonstrated the antimicrobial activities of Zanthoxylumleprieurii essential oil from Cameroon [13]. However, in the best our knowledge there is no report on the antifungal properties of this oil against E. floccosumand T. rubrum.The aim of this study was to analyze the chemical composition of Zanthoxylumleprieuriiessential oils and to evaluate their antioxidant and antifungal activities against E. floccosumand T. rubrum, the two most common causal agents of cutaneous mycosis.…”

Section: Introductionmentioning

confidence: 67%

Chemical composition, free radical scavenging and antifungal activity ofZanthoxylumleprieuriiessential oils against Epidermophytonfloccosum and Trichophytonrubrum

Tchabong¹,

S.R.²,

D.P.M.³

et al. 2017

IOSRPHR

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ABSTRACT-Background: These investigations were carried out to analyze the chemical composition, to evaluate the radical scavenging, and the anti-fungal activities of essential oils from leaves and fruits of Zanthoxylumleprieurii.Methods: Oils were obtained by hydro distillation using Clevenger-type apparatus. The compounds were identified by gas chromatography and gas chromatography coupled with Mass Spectrometry. Antifungal activity of the essential oils was tested in vitro against Epidermophytonfloccosum and Trichophytonrubrumwhile free radical scavenging activity evaluation was done using 2,2-diphenyl picrylhydrazyl method. Results:Results showed that, the major components of the leaves oil were (E)-ß-ocimene (91.5 %) while the most abundant component from fruits oil were (E)-ß-Ocimene (90.3 %). The total growth inhibition of the pathogens by fruits essential oil occurred at 4.0 mg/ml and 3.0 mg/ml respectively, forEpidermophytonfloccosum and Trichophytonrubrum. The leaves oil exhibited total growth inhibition at 4.0 mg/ml against both pathogens. These oils also showed antioxidant activities with SC50 values at 2.0 mg/ml and 5.0 mg/ml respectively, for fruits and leaves. There were positive and significant correlations between mycelia growth inhibition of both pathogens and the antioxidant activities of the tested oils noted. Conclusion:These results showed that, Z. leprieurii essential oils could be used as a resource of antioxidant and antidermatophitic compounds with may find applications in pharmaceutical industries.

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Section: Introductionmentioning

confidence: 67%

Chemical composition, free radical scavenging and antifungal activity ofZanthoxylumleprieuriiessential oils against Epidermophytonfloccosum and Trichophytonrubrum

Tchabong¹,

S.R.²,

D.P.M.³

et al. 2017

IOSRPHR

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“…[3] Z. xanthoxyloides is traditionally used to cure toothache, sickle cell anaemia, cancers, urinary disorders, and many other diseases [4] and its antifungal, antibacterial and antileukaemic activities have been demonstrated. [5][6][7] In previous papers, divanilloylquinic acids and phenyltethanoid derivatives have been isolated from the root bark of this plant. [8,9] Z. leprieurii is used in the treatment of fever, coughs, colds, toothache [10] and some diseases caused by fungi, [6] and has been reported to contain cytotoxic acridone alkaloids.…”

Section: Introductionmentioning

confidence: 99%

Characterization and biological activity of essential oils from fruits of Zanthoxylum xanthoxyloides Lam. and Z. leprieurii Guill. & Perr., two culinary plants from Cameroon

Fogang

Tapondjou

Womeni

et al. 2012

Flavour & Fragrance J

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Essential oils obtained by hydrodistillation of dried fruits of Zanthoxylum xanthoxyloides and Z. leprieurii\ud (Rutaceae), were analysed by gas chromagraphy–flame ionization detection and gas chromatography–mass spectrometry. In the former, the major volatiles resulted citronellol (29.9%) and geraniol (11.5%), followed by citronellyl acetate (5.5%), limonene (5.5%) and citronellal (4.6%), while in the latter the major compounds were (E)-b-ocimene (29.4%), myrcene (28.6%), limonene (13.6%) and a-pinene (8.1%), respectively. The chemical composition supports the traditional use of these plants as spices in local food. The oils were also tested for antiproliferative, antimicrobial and antioxidant activities by MTT assay, agar disc diffusion method, and DPPH, ABTS and b-carotene–linoleic acid assay, respectively. The noteworthy cytotoxic effects of Z. xanthoxyloides are probably related to the presence of geraniol and citronellol, which exhibited strong antiproliferative activity against all the tested human tumor cell lines, and support the local traditional use of this plant for the treatment of various cancers

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“…Investigações fi toquímicas identifi caram alcalóides, fl avonóides, cumarinas, lignanas e terpenos no gênero (Talapatra et al, 1973;Stermitz;Sharifi , 1977;Diehl et al, 2000;Oliveira et al, 2002;Facundo et al, 2005;Tane et al, 2005). Propriedades antinociceptiva, antidiarréica, antimalárica, antioxidante, mutagênica, antimicrobiano, giardicida, entre outras, têm sido demonstradas em espécies de Zanthoxylum (Rahman et al, 2002;Tatsadjieu et al, 2003;Chung et al, 2006;Jullian et al, 2006;Amaral et al 2006).…”

Section: Introductionunclassified

Atividades farmacológicas dos extratos de Zanthoxylum chiloperone (Rutaceae)

Villalba¹,

Carmo²,

Leite³

et al. 2007

Rev. bras. farmacogn.

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RESUMO:Neste trabalho foram avaliadas as atividades antinociceptiva e antiinfl amatória dos extratos das folhas de Zanthoxylum chiloperone. Os ensaios foram realizados pelos testes de contorções abdominais induzidas por ácido acético, tempo da lambida da pata induzida por formalina, edema de pata e pleurisia induzidas por carragenina, usando os extratos hexânico, em acetato de etila e etanólico administrados nas doses de 100 e 200 mg/kg. As doses testadas reduziram, signifi cativamente, as contorções abdominais, o tempo de lambida da pata, o edema de pata, o volume do exsudato e a migração leucocitária. Estes resultados sugerem que os extratos de Z. chiloperone possuem constituintes com atividades antinociceptiva e antiinfl amatória.Unitermos: Zanthoxylum chiloperone, atividade antinociceptiva, atividade antiinfl amatória.ABSTRACT: "Pharmacological activities of Zanthoxylum chiloperone (Rutaceae) extracts". In this work the antinociceptive and anti-infl ammatory activities of the extracts of leaves from Zanthoxylum chiloperone were evaluated. The tests were carried out by acetic acid writhing, formalin-induced paw licking, carrageenan-induced rat paw edema and pleurisy methods, using hexane, ethyl acetate and ethanol extracts administered in the doses of 100 and 200 mg/kg. The doses inhibited, signifi cantly, the contortions, the paw lick, the paw edema, the volume of the exsudate and the leukocytes migration. These results suggest that the extracts from Z. chiloperone possess constituents with antinociceptive and anti-infl ammatory activities.

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Antibacterial and antifungal activity of Xylopia aethiopica, Monodora myristica, Zanthoxylum xanthoxyloı̈des and Zanthoxylum leprieurii from Cameroon

Cited by 117 publications

References 6 publications

Chemical composition, free radical scavenging and antifungal activity ofZanthoxylumleprieuriiessential oils against Epidermophytonfloccosum and Trichophytonrubrum

Chemical composition, free radical scavenging and antifungal activity ofZanthoxylumleprieuriiessential oils against Epidermophytonfloccosum and Trichophytonrubrum

Characterization and biological activity of essential oils from fruits of Zanthoxylum xanthoxyloides Lam. and Z. leprieurii Guill. & Perr., two culinary plants from Cameroon

Atividades farmacológicas dos extratos de Zanthoxylum chiloperone (Rutaceae)

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