Antibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives

Rahmoun, Mohammed Nadjib; Boucherit-Otmani, Z.; Boucherit, K.; Benabdallah, Mohammed; Villemin, Didier; Choukchou‐Braham, Noureddine

doi:10.1016/j.medmal.2012.05.002

Cited by 88 publications

(55 citation statements)

References 29 publications

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“…Some studies indicate that the antibacterial activity of a family of 1,4-naphthoquinones require a free keto group at position 1 and 4 and the substituent at position 2 must not be a hydroxyl group [8]. Some 1,4-naphthoquinones tested in the present study have a free keto function, and the most effective ones do not have a hydroxyl group at position 2.…”

Section: Discussionmentioning

confidence: 53%

“…They can also be prepared synthetically and are widely produced by the chemical industry as organic dyes [6]. The interest of naphthoquinones is not restricted to the chemistry of dyes; a wide spectrum of biological activities is described for them, including antitumor, antibacterial, anti-inflammatory, antiparasitic, cytotoxic activities and others [7,8,9]. These biological activities have justified the large number of studies found in the literature aimed at the synthesis and evaluation of either natural quinones or their analogues as potential pharmacological agents [10].…”

Section: Introductionmentioning

confidence: 99%

“…(henna) would indicate the probable involvement of lawsone, i.e. 2-hydroxynaphthoquinone, which is known to be the main bioactive constituent of this herb, in the antimicrobial activity [5,8]. …”

mentioning

confidence: 99%

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Antimicrobial Activities of the Henna Extract and Some Synthetic Naphthoquinones Derivatives

Rahmoun¹,

Boucherit-Atmani²,

Benabdallah³

et al. 2013

AJMBR

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Naphthoquinones are compounds widely distributed in the environment, both as natural products and as pharmaceutical agents. They have been the subject of much research due to their pharmacological activities. In this study, methanol extract of henna and a series of synthesized structural analogue of lawsone have been assessed for their antimicrobial activities. Methanol extract of henna and eight naphthoquinones derivatives were tested as potential antimicrobial agents against twelve bacteria and three Candida species using the agar disc diffusion and broth microdilution methods according to guidelines recommended by the Clinical and Laboratory Standards Institute. Besides 2b and 3b, methanol extract and all the synthesized compounds 1a, 2a, 1b and 1c, 2c and 3c showed weakto-strong activity against at least one tested strain. However, the compounds 1c and 1b were found to have the most effective activity against pathogenic bacteria and displayed an activity 8 to 64 fold higher than that othe structural analogue, lawsone. Their MICs ranged from 8-64 µg ml -1. Henna extract was found to have an interesting activity. Our results indicate an effective in vitro activity of 1,4-naphthoquinone derivatives and suggest the benefits of further studies for its application in antibiotherapy.

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Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activities of the Henna Extract and Some Synthetic Naphthoquinones Derivatives

Rahmoun¹,

Boucherit-Atmani²,

Benabdallah³

et al. 2013

AJMBR

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“…This may also be attributed to the presence of soluble phenolic and polyphenolic compounds [24] . Rahmoun [25,26] . The results are also in confirmation with some recent studies [27,28] .…”

Section: Discussionmentioning

confidence: 99%

Phytochemical screening, antimicrobial and antioxidant efficacy of different extracts of Rumex dentatus L. – A locally used medicinal herb of Kashmir Himalaya

Nisa

Kamili

Bandh

et al. 2013

Asian Pacific Journal of Tropical Disease

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“…Henna paste was prepared by soaking 100g of powdered plant in 900mL of water [13]. The mixture was stirred until it had a thick, pasty texture.…”

Section: In-vivo Sensitivity Testing Using Goatsmentioning

confidence: 99%

In Vitro and in Vivo Anti Dermatophytes Activity of Lawsonia Inermis L. (Henna) Leaves against Ringworm and Its Etiological Agents

Wagini¹,

Abbas²,

Soliman³

et al. 2014

AJCEM

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Abstract:The study was carried out to identify the etiological agents causing ringworm, evaluate the in vitro and in vivo antifungal activity of Lawsonia inermis L. In vitro study was carried out using agar dilution method. In a total of 50 clinical samples, 4 different species were identified namely; Microsporum canis, Trichophyton tonsurans, Trichophyton rubrum, and Trichophyton mentagrophytes. However, the results showed that hexane extract exerted a strong antifungal activity against all the identified etiological agents, with a minimum inhibitory concentration of 625µg/ml except Microsporum canis which resisted the minimum concentration but susceptible to the higher concentrations. The in vivo study was carried out using 15 naturally infected goats. First, second and third group of animals were treated with henna paste, aqueous and ethanolic extract respectively, fourth group were treated with clotrimazole as a positive control while negative control (fifth) group were left untreated with neither henna nor clotrimazole. The treatments were compared and the results showed that henna paste had the highest efficacy against all the types of ringworm tested compared to the remaining treatments. Disappearance of lesion and complete repair of the hair was observed at 30 days after treatment. Significantly similar result was observed in the group of animals treated with aqueous extract, ethanol extract, and clotrimazole in all the parameters. Significant different was only observed between groups treated and negative control.

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Antibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives

Cited by 88 publications

References 29 publications

Antimicrobial Activities of the Henna Extract and Some Synthetic Naphthoquinones Derivatives

Antimicrobial Activities of the Henna Extract and Some Synthetic Naphthoquinones Derivatives

Phytochemical screening, antimicrobial and antioxidant efficacy of different extracts of Rumex dentatus L. – A locally used medicinal herb of Kashmir Himalaya

In Vitro and in Vivo Anti Dermatophytes Activity of Lawsonia Inermis L. (Henna) Leaves against Ringworm and Its Etiological Agents

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