Antibacterial and anti-inflammatory properties of Plantago ovata Forssk. leaves and seeds against periodontal pathogens: An in vitro study

Reddy, P Ravi Tejeshwar; Vandana, Kangowkar V; Prakash, Shobha

doi:10.4103/ayu.ayu_176_16

Cited by 13 publications

(10 citation statements)

References 21 publications

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“…Studies have reported that L. usitatissimum has analgesic and anti-inflammatory properties [ 82 ]. The improvement in HRQoL can be accredited to the anti-inflammatory, antioxidant, analgesic [ 14 ] and immunomodulatory [ 83 ] properties of P. ovata . L. usitatissimum has analgesic [ 26 ] and antioxidant properties [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

et al. 2023

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A single-blind double-dummy randomized study was conducted in diagnosed patients (n = 66) to compare the efficacy of Linseeds (Linum usitatissimum L.), Psyllium (Plantago ovata Forssk.), and honey in uncomplicated pelvic inflammatory disease (uPID) with standard drugs using experimental and computational analysis. The pessary group received placebo capsules orally twice daily plus a per vaginum cotton pessary of powder from linseeds and psyllium seeds, each weighing 3 gm, with honey (5 mL) at bedtime. The standard group received 100 mg of doxycycline twice daily and 400 mg of metronidazole TID orally plus a placebo cotton pessary per vaginum at bedtime for 14 days. The primary outcomes were clinical features of uPID (vaginal discharge, lower abdominal pain (LAP), low backache (LBA), and pelvic tenderness. The secondary outcomes included leucocytes (WBCs) in vaginal discharge on saline microscopy and the SF-12 health questionnaire. In addition, we also classified both (pessary and standard) groups using machine learning models such as Decision Tree (DT), Random Forest (RF), Logistic Regression (LR), and AdaBoost (AB). The pessary group showed a higher percentage reduction than the standard group in abnormal vaginal discharge (87.05% vs. 77.94%), Visual Analogue Scale (VAS)-LAP (80.57% vs. 77.09%), VAS-LBA (74.19% vs. 68.54%), McCormack pain scale (McPS) score for pelvic tenderness (75.39% vs. 67.81%), WBC count of vaginal discharge (87.09% vs. 83.41%) and improvement in SF-12 HRQoL score (94.25% vs. 86.81%). Additionally, our DT 5-fold model achieved the maximum accuracy (61.80%) in the classification. We propose that the pessary group is cost-effective, safer, and more effective as standard drugs for treating uPID and improving the HRQoL of women. Aucubin, Plantamajoside, Herbacetin, secoisolariciresinol diglucoside, Secoisolariciresinol Monoglucoside, and other various natural bioactive molecules of psyllium and linseeds have beneficial effects as they possess anti-inflammatory, antioxidant, antimicrobial, and immunomodulatory properties. The anticipated research work is be a better alternative treatment for genital infections.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

et al. 2023

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“…1 • Supplementation of Zinc may alter periodontal disease progression through changes in expression of the ZnT8 transporter gene .12 • Isabgol extract has shown effective antibiotic and weakinflammatory effect by effective action against periodontal pathogens and Matrix metalloproteins. 13 • Omega 3 from polyunsaturated fatty acid act as a signal to prevent neutrophils mediated periodontal tissue damage. 14 • The hydro-alcoholic extract from pomegranate has shown to decrease the Colony Forming Units (CFU'S) per millimeters of dental plaque by 84 % by one minute rinse.…”

Section: Nutrients For Periodontal Healthmentioning

confidence: 99%

Nutrigenomics and its Role in Periodontal Health – A Review

2020

IJFMT

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Nutrigenomics is an emerging form of science involving tools that assess the benefit of diet and nutrition in various disease conditions at molecular and genetic level. Nutrigenomics investigates the relationship of nutrient regimen in maintaining health. This article reviews the role of nutrients in maintaining periodontal health and the use of nutrigenomics in understanding genotype, phenotype diet interactions on periodontal health of an individual and the effect of dietary modification on periodontal disease progression.

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“…PO is a naturally occurring compound that possesses benefits including affordability, sustainability, safety profile and accessibility 31 . The PO was first used for purpose of wound healing 32 . Further investigation demonstrated that extract of PO has therapeutic activities including antioxidant, anti-inflammatory, immuno-modulatory and analgesic, among others 33 .…”

Section: Introductionmentioning

confidence: 99%

Multifunctional green synthesized Cu–Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities

Kiani

Bagherzadeh

Ghadiri

et al. 2022

Sci Rep

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Doxorubicin (DOX) is a potent anti-cancer agent and there have been attempts in developing nanostructures for its delivery to tumor cells. The nanoparticles promote cytotoxicity of DOX against tumor cells and in turn, they reduce adverse impacts on normal cells. The safety profile of nanostructures is an important topic and recently, the green synthesis of nanoparticles has obtained much attention for the preparation of biocompatible carriers. In the present study, we prepared layered double hydroxide (LDH) nanostructures for doxorubicin (DOX) delivery. The Cu–Al LDH nanoparticles were synthesized by combining Cu(NO3)2·3H2O and Al(NO3)3·9H2O, and then, autoclave at 110. The green modification of LDH nanoparticles with Plantago ovata (PO) was performed and finally, DOX was loaded onto nanostructures. The FTIR, XRD, and FESEM were employed for the characterization of LDH nanoparticles, confirming their proper synthesis. The drug release study revealed the pH-sensitive release of DOX (highest release at pH 5.5) and prolonged DOX release due to PO modification. Furthermore, MTT assay revealed improved biocompatibility of Cu–Al LDH nanostructures upon PO modification and showed controlled and low cytotoxicity towards a wide range of cell lines. The CLSM demonstrated cellular uptake of nanoparticles, both in the HEK-293 and MCF-7 cell lines; however, the results were showed promising cellular internalizations to the HEK-293 rather than MCF-7 cells. The in vivo experiment highlighted the normal histopathological structure of kidneys and no side effects of nanoparticles, further confirming their safety profile and potential as promising nano-scale delivery systems. Finally, antibacterial test revealed toxicity of PO-modified Cu–Al LDH nanoparticles against Gram-positive and -negative bacteria.

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Antibacterial and anti-inflammatory properties of Plantago ovata Forssk. leaves and seeds against periodontal pathogens: An in vitro study

Cited by 13 publications

References 21 publications

Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

Nutrigenomics and its Role in Periodontal Health – A Review

Multifunctional green synthesized Cu–Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities

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