Antibacterial Activity within Degradation Products of Biological Scaffolds Composed of Extracellular Matrix

Tissue engineered human tracheas for in vivo implantation

“…Matrices from natural sources provide a structure and composition nearly identical to their native state, informative signals which facilitate cell attachment, migration and interaction with the host tissue, and inherently contain components that inhibit the growth of bacteria and other infective agents [21].…”

Utilization of a Tubularized CorMatrix Extracellular Matrix for Repair of an Arteriovenous Fistula Aneurysm

“…Additional research done on this topic has demonstrated that ECM scaffolds such as CorMatrix ECM harbor several lowemolecular-weight peptides with antibacterial activity that may protect vascular conduits made with these materials from infection. 11 The optimal management of AVF aneurysm remains a clinical challenge. Although several algorithms for the treatment of these complications have been proposed, durability and infection after revision remain significant concerns.…”

Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration

“…Collagen is the most abundant molecule within mammalian ECM and comprises nearly 90% of its dry weight [80]. In addition to maintaining the structure of each tissue, GAGs and low molecular weight cryptic oligopeptides released or exposed by the degradation of structural ECM such as collagen and fibronectin are known to possess significant biologic activity [58][59][60][81][82][83][84]. Type I collagen is the predominant isoform in skeletal muscle tissue [85].…”