Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration

Badylak, Stephen F.; Dziki, Jenna L.; Sicari, Brian M.; Ambrosio, Fabrisia; Boninger, Michael L.

doi:10.1016/j.biomaterials.2016.06.047

Cited by 64 publications

(51 citation statements)

References 131 publications

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“…Type IV collagen is present within the basement membrane in a smaller proportion, in addition to other specialized molecules such as laminin, which is abundantly present within the basement membrane . ECM‐bound growth factors, matrix stiffness, and topography all influence repopulating cell behavior . Ultimately, ECM is a substrate that acts as a conduit in the native environment to promote cellular ingrowth and subsequent tissue regeneration.…”

Section: Promoting Muscle Regenerationmentioning

confidence: 99%

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

et al. 2018

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Section: Promoting Muscle Regenerationmentioning

confidence: 99%

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

et al. 2018

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“…The mechanisms underlying the reported functional improvements have yet to be elucidated, but it has been hypothesized that donor ECM-mediated response occurs through the recruitment of stem/progenitor cells at the site of implantation. 23–26 The application of rehabilitation protocols following ECM implantation has been suggested to be beneficial—even crucial—for providing the needed mechanical signals to encourage site-specific tissue remodeling (reviewed in 27,28 ). Future randomized studies to determine whether and how optimal rehabilitation protocols may enhance functional outcomes following the application of a tissue engineering device for the treatment of VML are warranted.…”

Section: Successes In Regenerative Rehabilitation and Related Therapiesmentioning

confidence: 99%

Regenerative Rehabilitation: Combining Stem Cell Therapies and Activity-Dependent Stimulation

Moritz

Ambrosio

2017

Pediatric Physical Therapy

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The number of clinical trials in regenerative medicine is burgeoning, and stem cell/tissue engineering technologies hold the possibility of becoming the standard of care for a multitude of diseases and injuries. Advances in regenerative biology reveal novel molecular and cellular targets with potential to optimize tissue healing and functional recovery, thereby refining rehabilitation clinical practice. The purpose of this review is to: 1) highlight the potential for synergy between the fields of regenerative medicine and rehabilitation, a convergence of disciplines known as Regenerative Rehabilitation; 2) provide translational examples of Regenerative Rehabilitation within the context of neuromuscular injuries and diseases, and 3) offer recommendations for ways to leverage activity-dependence via combined therapy and technology with the goal of enhancing long-term recovery. The potential clinical benefits of Regenerative Rehabilitation will likely become a critical aspect in the standard of care for many neurological and musculoskeletal disorders.

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“…Biomaterials encompass various facets of medicine, 1 biology, 2 chemistry, 3,4 and materials science. 5 Their applications include scaffolds for cell culture 6–10 and catalytic reactions, 11–15 devices, 16–23 and bioimplants.…”

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confidence: 99%

Structural and Mechanical Properties of Amyloid Beta Fibrils: A Combined Experimental and Theoretical Approach

Paul

Hoffmann

Wang

et al. 2016

J. Phys. Chem. Lett.

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In this combined experimental (deep ultraviolet resonance Raman (DUVRR) spectroscopy and atomic force microscopy (AFM)) and theoretical (molecular dynamics (MD) simulations and stress–strain (SS)) study, the structural and mechanical properties of amyloid beta (Aβ40) fibrils have been investigated. The DUVRR spectroscopy and AFM experiments confirmed the formation of linear, unbranched and β-sheet rich fibrils. The fibrils (Aβ40)n, formed using n monomers, were equilibrated using all-atom MD simulations. The structural properties such as β-sheet character, twist, interstrand distance, and periodicity of these fibrils were found to be in agreement with experimental measurements. Furthermore, Young’s modulus (Y) = 4.2 GPa computed using SS calculations was supported by measured values of 1.79 ± 0.41 and 3.2 ± 0.8 GPa provided by two separate AFM experiments. These results revealed size dependence of structural and material properties of amyloid fibrils and show the utility of such combined experimental and theoretical studies in the design of precisely engineered biomaterials.

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Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration

Cited by 64 publications

References 131 publications

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

Regenerative Rehabilitation: Combining Stem Cell Therapies and Activity-Dependent Stimulation

Structural and Mechanical Properties of Amyloid Beta Fibrils: A Combined Experimental and Theoretical Approach

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