Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

Sarrafian, Tiffany L.; Bodine, Sue C.; Murphy, Brian G; Grayson, J.; Stover, Susan M.

doi:10.1111/vsu.12787

Cited by 36 publications

(30 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While mice and rats are the most commonly utilized pre-clinical animal models because of the ease of conducting high throughput studies with standardized injury models, they typically create defects that are orders of magnitude smaller than those seen clinically. More recently, researchers have used larger preclinical animal models including dogs [138] and pigs [268], which generate defects on a more clinically relevant scale [269]. Additionally, muscles in varying anatomical locations have different functions, anatomy, and mechanical loading, which can influence regenerative outcomes [269].…”

Section: Discussionmentioning

confidence: 99%

“…More recently, researchers have used larger preclinical animal models including dogs [138] and pigs [268], which generate defects on a more clinically relevant scale [269]. Additionally, muscles in varying anatomical locations have different functions, anatomy, and mechanical loading, which can influence regenerative outcomes [269]. Musculoskeletal injury methods also vary and include myotoxic agents, hindlimb ischemia, and partial or total resection models.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Skeletal Muscle Tissue Engineering: Biomaterials-Based Strategies for the Treatment of Volumetric Muscle Loss

Carnes

Pins

2020

Bioengineering

View full text Add to dashboard Cite

Millions of Americans suffer from skeletal muscle injuries annually that can result in volumetric muscle loss (VML), where extensive musculoskeletal damage and tissue loss result in permanent functional deficits. In the case of small-scale injury skeletal muscle is capable of endogenous regeneration through activation of resident satellite cells (SCs). However, this is greatly reduced in VML injuries, which remove native biophysical and biochemical signaling cues and hinder the damaged tissue’s ability to direct regeneration. The current clinical treatment for VML is autologous tissue transfer, but graft failure and scar tissue formation leave patients with limited functional recovery. Tissue engineering of instructive biomaterial scaffolds offers a promising approach for treating VML injuries. Herein, we review the strategic engineering of biophysical and biochemical cues in current scaffold designs that aid in restoring function to these preclinical VML injuries. We also discuss the successes and limitations of the three main biomaterial-based strategies to treat VML injuries: acellular scaffolds, cell-delivery scaffolds, and in vitro tissue engineered constructs. Finally, we examine several innovative approaches to enhancing the design of the next generation of engineered scaffolds to improve the functional regeneration of skeletal muscle following VML injuries.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Tissue Engineering: Biomaterials-Based Strategies for the Treatment of Volumetric Muscle Loss

Carnes

Pins

2020

Bioengineering

View full text Add to dashboard Cite

show abstract

“…Approximately 90% of preclinical models of VML have been conducted in mice and rats [33]. However, a standard VML model with respect to muscle anatomical location and defect size has not been defined.…”

Section: Animal Models Of Vmlmentioning

confidence: 99%

“…However, a standard VML model with respect to muscle anatomical location and defect size has not been defined. The latissimus dorsi (LD), tibialis anterior (TA), quadriceps and abdominal wall muscles are the most frequently ablated muscles in experimentally induced VML [33]. Although in most VML models more than 20% of the muscle mass is ablated, Anderson et al reported that 15% muscle ablation was the critical threshold for irreversible muscle loss.…”

Section: Animal Models Of Vmlmentioning

confidence: 99%

Pre-Clinical Cell Therapeutic Approaches for Repair of Volumetric Muscle Loss

Shayan

Huang

2020

Bioengineering

View full text Add to dashboard Cite

Extensive damage to skeletal muscle tissue due to volumetric muscle loss (VML) is beyond the inherent regenerative capacity of the body, and results in permanent functional debilitation. Current clinical treatments fail to fully restore native muscle function. Recently, cell-based therapies have emerged as a promising approach to promote skeletal muscle regeneration following injury and/or disease. Stem cell populations, such as muscle stem cells, mesenchymal stem cells and induced pluripotent stem cells (iPSCs), have shown a promising capacity for muscle differentiation. Support cells, such as endothelial cells, nerve cells or immune cells, play a pivotal role in providing paracrine signaling cues for myogenesis, along with modulating the processes of inflammation, angiogenesis and innervation. The efficacy of cell therapies relies on the provision of instructive microenvironmental cues and appropriate intercellular interactions. This review describes the recent developments of cell-based therapies for the treatment of VML, with a focus on preclinical testing and future trends in the field.

show abstract

“…Biomaterials are pivotal, as their interaction with the seeded cells will determine the final result of the tissue-engineered construct. For this aim, dealing with biologically derived materials seems to be a reasonable option, if the most relevant biochemical cues are preserved [ 9 , 15 , 16 ].…”

Section: Moving Towards Biomimetic Engineered Muscular Constructsmentioning

confidence: 99%

Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds

Baiguera

Gaudio²,

Carotenuto

et al. 2020

Nanomaterials

View full text Add to dashboard Cite

Severe muscle injuries are a real clinical issue that still needs to be successfully addressed. Tissue engineering can represent a potential approach for this aim, but effective healing solutions have not been developed yet. In this regard, novel experimental protocols tailored to a biomimetic approach can thus be defined by properly systematizing the findings acquired so far in the biomaterials and scaffold manufacturing fields. In order to plan a more comprehensive strategy, the extracellular matrix (ECM), with its properties stimulating neomyogenesis and vascularization, should be considered as a valuable biomaterial to be used to fabricate the tissue-specific three-dimensional structure of interest. The skeletal muscle decellularized ECM can be processed and printed, e.g., by means of stereolithography, to prepare bioactive and biomimetic 3D scaffolds, including both biochemical and topographical features specifically oriented to skeletal muscle regenerative applications. This paper aims to focus on the skeletal muscle tissue engineering sector, suggesting a possible approach to develop instructive scaffolds for a guided healing process.

show abstract

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

Cited by 36 publications

References 123 publications

Skeletal Muscle Tissue Engineering: Biomaterials-Based Strategies for the Treatment of Volumetric Muscle Loss

Skeletal Muscle Tissue Engineering: Biomaterials-Based Strategies for the Treatment of Volumetric Muscle Loss

Pre-Clinical Cell Therapeutic Approaches for Repair of Volumetric Muscle Loss

Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds

Contact Info

Product

Resources

About