Antibacterial activity on superhydrophobic titania nanotube arrays

Abstract

Bacterial infections are a serious issue for many implanted medical devices. Infections occur when bacteria colonize the surface of an implant and form a biofilm, a barrier which protects the bacterial colony from antibiotic treatments. Further, the anti-bacterial treatments must also be tailored to the specific bacteria that is causing the infection. The inherent protection of bacteria in the biofilm, differences in bacteria species (gram-positive vs. gram-negative), and the rise of antibiotic-resistant strains of bacteria makes device-acquired infections difficult to treat. Recent research has focused on reducing biofilm formation on medical devices by modifying implant surfaces. Proposed methods have included antibacterial surface coatings, release of antibacterial drugs from surfaces, and materials which promote the adhesion of non-pathogenic bacteria. However, no approach has proven successful in repelling both gram-positive and gram-negative bacteria. In this study, we have evaluated the ability of superhydrophobic surfaces to reduce bacteria adhesion regardless of whether the bacteria are gram-positive or gram-negative. Although superhydrophobic surfaces did not repel bacteria completely, they had minimal bacteria attached after 24 h and more importantly no biofilm formation was observed.

Study of 1D Titanate‐Based Materials –New Modification of the Synthesis Procedure and Surface Properties‐Recent Applications

“…TiNTs have potential applications in several fields; they are found in biomaterials, gas sensors, adsorbents, heterogeneous catalysis ( photocatalysis, oxidation reactions, organic synthesis, biomass,…), biological activities to remove bacteria from water, solar cells, Li battery production, and many others. In particular, TiNTs have been used as a catalytic support for different active species (metals, oxides and sulfides).…”

Enhanced hemocompatibility and antibacterial activity on titania nanotubes with tanfloc/heparin polyelectrolyte multilayers

“…The S. aureus pellet was resuspended in NBM solution and an aliquot of P. aeruginosa was taken from the agar plate and dissolved in NBM. Both bacteria solutions were incubated at 37°C for 24 hr until the optical density at 600 nm was approximately 1 (Bartlet, Movafaghi, Dasi, Kota, & Popat, ).…”

Visible-Light Active Titanium Dioxide Nanomaterials with Bactericidal Properties

“…Recently, Bartlet et al indicated that one-dimensional titania nanotubes prepared by electrochemical anodization exhibit superhydrophobic behavior with a large water contact angle of >150°. Such superhydrophobic titania nanotubes reduced bacterial adhesion on their surfaces [82]. Reproduced with permission from [42].…”