Antibacterial activity of quaternized chitosan modified nanofiber membrane

Cheah, Wai Yan; Show, Pau Loke; Ng, I‐Son; Lin, Guan‐Yu; Chiu, Chen-Yaw; Chang, Yu-Kaung

doi:10.1016/j.ijbiomac.2018.12.193

Cited by 130 publications

(52 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Quaternization generally occurs via three methods, namely direct quaternary ammonium substitution, N-alkylation, and the epoxy derivative open loop method [65][66][67][68][69]. In recent years, the most commonly used quaternary ammonium salts have been GTA (2,3-epoxypropyl trimethyl ammonium chloride) and CTA (3-chloro-2-hydroxypropyl trimethyl) [15,70]. N,N,N-trimethyl chitosan (TMC) is a quaternary ammonium chitosan.…”

Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

“…chloro-2-hydroxypropyl trimethyl) [15,70]. N,N,N-trimethyl chitosan (TMC) is a quaternary ammonium chitosan.…”

Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

“…Chitosan and chitosan derivatives have been widely used as non-toxic or low-toxicity antibacterial materials [123]. Among them, chitosan quaternary ammonium salt is the most widely used [15,83]. Table 1 summarizes the antimicrobial species and applications of quaternized chitosan derivatives.…”

Section: Application In the Antibacterial Materialsmentioning

confidence: 99%

“…The antibacterial mechanism of chitosan and quaternized chitosan is still inconclusive. There are only three speculations [15,81]: (1) Chitosan and chitosan derivatives are positively charged, while bacteria are negatively charged, causing them to attract and interact with each other due to electrostatic adsorption; (2) after adsorbing bacteria, chitosan and chitosan derivatives enter the inside of bacterial cells and bind to DNA, which interferes with the transcription of bacterial DNA, thereby inhibiting the growth of bacteria; (3) chitosan and chitosan derivatives inhibit the uptake of trace elements and nutrients that are necessary for cell growth. The antibacterial mechanism of TMC is to form a complex with the cell membrane or interfere with gene expression to achieve an antibacterial effect [130].…”

Section: Antibacterial Species Applicationmentioning

confidence: 99%

“…With the development of nanotechnology, chitosan derivatives have been prepared as nanomaterials, including nanoparticles, hydrogels, microspheres, and micelles. Chitosan derivatives can be used as targeted delivery vehicles for drugs, as well as adjuvants and delivery carriers for vaccines [14][15][16][17][18][19][20]. Therefore, chitosan derivatives and their nanomaterials can be widely used and expanded upon in terms of the fields of chitosan application [21,22].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

530

326

View full text Add to dashboard Cite

Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

show abstract

Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

“…chloro-2-hydroxypropyl trimethyl) [15,70]. N,N,N-trimethyl chitosan (TMC) is a quaternary ammonium chitosan.…”

Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

Section: Application In the Antibacterial Materialsmentioning

confidence: 99%

Section: Antibacterial Species Applicationmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

530

326

View full text Add to dashboard Cite

show abstract

Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing

Zheng

Tong

Zhang

et al. 2021

Adv Funct Materials

145

106

View full text Add to dashboard Cite

Real‐time monitoring of wound healing remains a major challenge in clinical tissue regeneration, calling the need for the development of biomaterial‐guided on‐site monitoring wound healing technology. In this study, multifunctional double colorimetry‐integrated polyacrylamide‐quaternary ammonium chitosan‐carbon quantum dots (CQDs)‐phenol red hydrogels are presented, aiming to simultaneously detect the wound pH level, reduce bacterial infection, and promote wound healing. The hybridization of CQDs and pH indicator (phenol red) with the hydrogels enables their high responsiveness, reversibility, and accurate indication of pH variability to reflect the dynamic wound status in the context of both ultraviolet and visible light. Furthermore, these visual images can be collected by smartphones and converted into on‐site wound pH signals, allowing for a real‐time evaluation of the wound dynamic conditions in a remote approach. Notably, the hydrogels exhibit excellent hemostatic and adhesive properties, maintain sufficient wound moisture, and promote wound healing via their high antibacterial activity (against Staphylococcus Aureus, and Escherichia Coli) and skin repair function. Overall, the resulting hydrogels have high potential as a novel smart and flexible wound dressing platform for theranostic skin regeneration.

show abstract

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Jin

Gao

Liu

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated the unique advances in biomedical applications due to its prominent role in regulating physiological/pathophysiological activities in terms of vasodilation, angiogenesis, chemosensitizing effect, and bactericidal effect. However, it is challenging to deliver NO, due to its short half-life (<5 s) and short diffusion distances (20-160 µm). To address these, various polymeric NO delivery nanoplatforms (PNODNPs) have been developed for cancer therapy, antimicrobial and cardiovascular therapeutics, because of the important advantages of polymeric delivery nanoplatforms in terms of controlled release of therapeutics and the extremely versatile nature. This reviews highlights the recent significant advances made in PNODNPs for NO storing and targeting delivery. The ideal and unique criteria that are required for PNODNPs for treating cancer, cardiovascular diseases and infection, respectively, are summarized. Hopefully, effective storage and targeted delivery of NO in a controlled manner using PNODNPs could pave the way for NO-sensitized synergistic therapy in clinical practice for treating the leading death-causing diseases.

show abstract

Antibacterial activity of quaternized chitosan modified nanofiber membrane

Cited by 130 publications

References 43 publications

Chitosan Derivatives and Their Application in Biomedicine

Chitosan Derivatives and Their Application in Biomedicine

Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Contact Info

Product

Resources

About