Antibacterial Activity of Graphdiyne and Graphdiyne Oxide

Zhu, Zhiling; Bai, Qiang; Li, Shuo; Li, Siheng; Liu, Manhong; Du, Fanglin; Sui, Ning; Yu, William W.

doi:10.1002/smll.202001440

Cited by 85 publications

(72 citation statements)

References 68 publications

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“…118 It was also found that cellular membranes of bacteria could be pierced by the extremely sharp edges of graphdyine nanosheets, causing the leakage of intracellular substances. 119 The antibacterial activity of graphdyine was higher in comparison to graphene and GO. Therefore, potential similar antiviral effects can be expected for graphdiyne and possibly Ti3C2Tx MXene and also for other 2DMs with high flexibility, stiffness, and strains.…”

Section: Future Possibilities For Functionalization Of 2dms Against Virusesmentioning

confidence: 96%

Two-Dimensional Material-Based Biosensors for Virus Detection

2020

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Viral infections are one of the major causes of mortality and economic losses worldwide. Consequently, efficient virus detection methods are crucial to determine the infection prevalence. However, most detection methods face challenges related to false-negative or falsepositive results, long response times, high costs, and/or the need for specialized equipment and staff. Such issues can be overcome by access to low-cost and fast response point-of-care detection systems, and two-dimensional materials (2DMs) can play a critical role in this regard. Indeed, the unique and tunable physicochemical properties of 2DMs provide many advantages for developing biosensors for viral infections with high sensitivity and selectivity. Fast, accurate, and reliable detection, even at early infection stages by the virus, can be potentially enabled by highly accessible surface interactions between the 2DMs and the analytes. High selectivity can be obtained by functionalization of the 2DMs with antibodies, nucleic acids, proteins, peptides or aptamers, allowing for specific binding to a particular virus, viral fingerprints or proteins released by the host organism. Multiplexed detection and discrimination between different virus strains are also feasible. In this review, we present a comprehensive overview of the major advances of 2DMbased biosensors for the detection of viruses. We describe the main factors governing the efficient interactions between viruses and 2DMs, making them ideal candidates for the detection of viral infections. We also critically detail their advantages and drawbacks, providing insights for the development of future biosensors for virus detection. Lastly, we provide suggestions to stimulate research in the fast expanding field of 2DMs that could help in designing advanced systems for preventing virus-related pandemics.

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Section: Future Possibilities For Functionalization Of 2dms Against Virusesmentioning

confidence: 96%

Two-Dimensional Material-Based Biosensors for Virus Detection

2020

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“…Zhu et al [107] studied the bacterial toxicity of GDY and GDYO, and further explored the antibacterial mechanism of GDY. The investigation of the antibacterial behaviors of GDY based nanomaterials may provide useful guidelines for the future design and application of this novel molecular allotrope of carbon [107] .…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Similar to the destructive effect of graphene on bacterial pathogen membrane [141,142] , GDY can also induce the collapse of bacterial cell membrane by capturing or wrapping bacterial cell membrane. Zhu et al [107] observed the formation of GDY and bacteria aggregation in bacterial culture. With the extension of culture time, the bacterial cell had no deformation, meaning that wrapping bacterial membrane was a possible way to inhibit bacterial growth.…”

Section: Physical/mechanical Punctuationmentioning

confidence: 99%

“…In order to understand the potential mechanism of antibacterial effect of GDY, as mentioned above, Zhu et al [107] explored the effect of GDY on the bacterial metabolism through differential gene expression analysis. The analysis of gene expression showed that the presence of GDY would disturb multiple genes responsible for bacterial metabolism.…”

Section: Inhibition Of Bacterial Metabolismmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Graphdiyne: from Preparation to Biomedical Applications

Guo

Chen

2021

Chem. Res. Chin. Univ.

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Graphdiyne(GDY) is a kind of two-dimensional carbon nanomaterial with specific configurations of sp and sp 2 carbon atoms. The key progress in the preparation and application of GDY is bringing carbon materials to a brand-new level. Here, the various properties and structures of GDY are introduced, including the existing strategies for the preparation and modification of GDY. In particular, GDY has gradually emerged in the field of life sciences with its unique properties and performance, therefore, the development of biomedical applications of GDY is further summarized. Finally, the challenges of GDY toward future biomedical applications are discussed.

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Plasmonic Nanozyme of Graphdiyne Nanowalls Wrapped Hollow Copper Sulfide Nanocubes for Rapid Bacteria‐Killing

Bai

Liang

et al. 2022

Adv Funct Materials

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Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface plasmon resonance (LSPR) response in the near‐infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal effects, resulting in dramatically increased peroxidase‐like activity when exposed to 808 nm light. Both experimental results and theoretical calculations show that the remarkable catalytic performance of CuS@GDY is due to the unique hierarchical structure, narrow bandgap of GDY nanowalls, LSPR effect of CuS nanocages, fast interfacial electron transfer dynamics, and carbon vacancies on CuS@GDY. This plasmonic nanozyme exhibits rapid, efficient, broad‐spectrum antibacterial activity (>99.999%) against diverse pathogens (methicillin‐resistant Staphylococcus aureus, Staphylococcus aureus, and Escherichia coli). This study not only sheds light on the mechanism of the nanozyme‐/photocatalysis coupling process, but also opens up a new avenue for engineering plasmonic NIR light driven nanozymes for rapid synergistic photothermal and photo‐enhanced nanozyme therapy.

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Antibacterial Activity of Graphdiyne and Graphdiyne Oxide

Cited by 85 publications

References 68 publications

Two-Dimensional Material-Based Biosensors for Virus Detection

Two-Dimensional Material-Based Biosensors for Virus Detection

Graphdiyne: from Preparation to Biomedical Applications

Plasmonic Nanozyme of Graphdiyne Nanowalls Wrapped Hollow Copper Sulfide Nanocubes for Rapid Bacteria‐Killing

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