Plasmonic Nanozyme of Graphdiyne Nanowalls Wrapped Hollow Copper Sulfide Nanocubes for Rapid Bacteria‐Killing

Abstract

Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface plasmon resonance (LSPR) response in the near‐infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal effects, resulting in dramatically increased peroxidase‐like activity when exposed to 808 nm light. Both experimental results and theoretical calculations show that the remarkable catalytic performance of CuS@GDY is due to the unique hierarchical structure, narrow bandgap of GDY nanowalls, LSPR effect of CuS nanocages, fast interfacial electron transfer dynamics, and carbon vacancies on CuS@GDY. This plasmonic nanozyme exhibits rapid, efficient, broad‐spectrum antibacterial activity (>99.999%) against diverse pathogens (methicillin‐resistant Staphylococcus aureus, Staphylococcus aureus, and Escherichia coli). This study not only sheds light on the mechanism of the nanozyme‐/photocatalysis coupling process, but also opens up a new avenue for engineering plasmonic NIR light driven nanozymes for rapid synergistic photothermal and photo‐enhanced nanozyme therapy.

Efficient nanozyme engineering for antibacterial therapy

“…Taking advantage of NIR-enhanced POD-like activity, the N-GDQDs/AuAg NC nanozyme possessed efficient broad-spectrum antibacterial activity under NIR irradiation. Similar enhanced effect can be found for the Au/CeO 2 plasmonic nanohybrids [91] and graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) [50] with strong LSPR absorption and fast hot electrons transfer efficiency. Overall, the NIR stimuli will be a promising spatiotemporal way to enhance the catalytic process of nanozymes.…”

“…Au [19][20][21][22][23][24][25][26], Pt [27], Cu [28], Ir [29], Ag [30], Au-Pt [31,32], Pd-Cu [33], Pd-Pt [34], Au-Ag [35], etc), transition metal oxide or sulfide (e.g. Fe 3 O 4 [36][37][38], CuO [39], CeO 2 [40], V 2 O 5 [41], Co-V mixed metal oxide (MMO) [42], MoS 2 [43][44][45][46][47], NiS 2 [48], CuS [49][50][51][52], Co 4 S 3 [53], MnO 2 [54] etc), and nanocarbon (e.g. boron doped graphdiyne (B-GDY) [8], N-doped sponge-like carbon spheres (N-SCSs) [55], graphene quantum dots [56,57], etc)-based nanozymes, to recentlyadvanced metal organic framework (MOF) (e.g.…”

NiSe and CoSe Topological Nodal‐Line Semimetals: A Sustainable Platform for Efficient Thermoplasmonics and Solar‐Driven Photothermal Membrane Distillation

“…[1] Upon illumination at the plasmon frequency, metal NPs display enhanced light absorption, enabling efficient light-to-heat conversion. [1a] Recently, thermoplasmonic effects have been successfully exploited mainly for biomedical applications, such as photothermal cancer therapy, [2] neural stimulation, [3] bacteria killing, [4] intracellular delivery of miRNA, [5] photothermal biosensors for SARS-CoV-2 detection. [6] Additionally, thermoplasmonic effects also play a pivotal role in photothermal actuators, [7] nanofurnaces for heterogeneous catalysis, [8] and solar-driven water evaporation.…”

Rapid Synthesis of Graphdiyne Films on Hydrogel at the Superspreading Interface for Antibacteria

“…In addition, it has been reported that GDY and its derivatives, such as graphdiyne oxide (GDYO), displayed great biosafety and compatibility for in vivo applications of antibacteria, biosensing and cancer therapy. , GDY and GDYO show antibacterial effects because of the generation of reactive oxygen species (ROS) . In particular, GDY and its complexes show excellent photothermal and photocatalytic performance enhancing the production of ROS. , Although the biomedical applications of GDY have been extensively studied, the use of GDY film with nanometer thickness was limited in the biomedical filed.…”