Antibacterial Activity of Diphenyltin(IV) and Triphenyltin(IV) 3-Chlorobenzoate Againts Pseudomonas aeruginosa and Bacillus subtilis

Annissa, Annissa; Suhartati, Tati; Yandri, Yandri; Hadi, Sutopo

doi:10.13005/ojc/330310

Cited by 20 publications

(5 citation statements)

References 15 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alternatif lain guna memperoleh senyawa yang efektif sebagai antibiotik adalah dikembangkannya senyawa baru dan diuji aktivitasnya (Hadi et al, 2021a;Mantravadi et al, 2019;Samsuar et al, 2021). Senyawa turunan organotimah telah dilaporkan memiliki berbagai aktivitas biologis yang sangat menarik sebagai antikanker dan antitumor (Hadi et al, 2012;Rehman et al, 2009;Sirajuddin et al, 2021;Uddin et al, 2021), antimalaria (Hadi et al, 2018b;Hadi et al, 2021b;Hansch and Verma, 2009), penghambat korosi (Hazani et al, 2019;Singh et al, 2010), dan antifungi (Rocha et al, 2016), juga diketahui memiliki aktivitas yang sangat baik dalam menghambat (membunuh) pertumbuhan bakteri (Annissa et al, 2017;Baul, 2008;Hadi et al, 2018a;Hadi et al, 2021a;Mantravadi et al, 2019;Samsuar et al, 2021). Kekuatan aktivitas senyawa organotimah terhadap bakteri, tidak…”

Section: Pendahuluanunclassified

Sintesis, Karakterisasi, dan Uji Aktivitas Antibakteri Senyawa Organotimah(IV) 4-Nitrobenzoat

2022

Self Cite

View full text Add to dashboard Cite

Dua buah senyawa organotimah(IV) yaitu berupa senyawa trifeniltimah(IV) 4-nitrobenzoat (2) dan difeniltimah(IV) di-4-nitrobenzoat (4) telah berhasil disintesis melalui reaksi antara senyawa trifeniltimah(IV) hidroksida (1) dan difeniltimah(IV) oksida (3) dengan ligan asam 4-nitrobenzoat (HNBA). Senyawa hasil sintesis dikarakterisasi dengan menggunakan spektrofotomer IR, spektrofotomer UV, spektrometer NMR dan microelemental analyzer untuk melihat kemurnian senyawa. Aktivitas biologis senyawa turunan organtotimah(IV) 4-nitrobenzoat telah diuji terhadap bakteri Gram positif Staphylococcus aureus dan Gram negatif Escherichia coli. Hasil uji dengan metode difusi agar menunjukkan senyawa 2 pada konsentrasi 200 ppm (3,87 × 10-4 M) memberikan penghambatan yang lebih efektif dibandingkan senyawa 4, senyawa awal 1 dan 3 serta ligan HNBA.Synthesis, Characterization, and Antibacterial Activity Test of Organotin(IV) 4-nitrobenzoate. Two organotin(IV) compounds, namely triphenyltin(IV) 4-nitrobenzoate (2) and diphenyltin(IV) di-4-nitrobenzoate (4) compounds have been successfully synthesized through a reaction between triphenyltin(IV) hydroxide (1) and diphenyltin(IV) oxide (3) with 4-nitrobenzoic acid (HNBA) The synthesized compounds were characterized using IR, UV, NMR spectrometer, and a microelemental analyzer to check the compound purity. The biological activity of the organotin(IV) 4-nitrobenzoate derivative was tested against Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli. The test results with the agar diffusion method showed that compound 2 at a concentration of 200 ppm (3.87 x 10-4 M) provide more effective inhibition than compound 4, the starting materials 1 and 3, and the ligand HNBA.

show abstract

Section: Pendahuluanunclassified

Sintesis, Karakterisasi, dan Uji Aktivitas Antibakteri Senyawa Organotimah(IV) 4-Nitrobenzoat

2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The current results from the study on organotin(IV) compounds have revealed that some organotin(IV) carboxylates show promising activities in many biological tests. For example, they have been widely used in the biological activities as antifungal (3,(7)(8)(9), antioxidant activities (10,11), antimalarial and antiplasmodial agents (12)(13)(14)(15), antiviral agents (16,17), antitumor and anticancer (18)(19)(20), corrosion inhibitor (21)(22)(23) and antibacterial (24)(25)(26)(27)(28)(29)(30). Moreover, these compounds have been found to exhibit strong activity as disinfectant (31).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Comparison of Disinfectant Bioactivity Test of Two Triphenyltin(IV) Compounds

SUSANGKA

Hadi

Noviany

et al. 2022

Journal of the Turkish Chemical Society Section A: Chemistry

Self Cite

View full text Add to dashboard Cite

This paper aims to report the synthesis of two new organotin(IV) carboxylate derivatives, triphenyltin(IV) 4-aminobenzoate (2) and triphenyltin(IV) 4-nitrobenzoate (3) and to examine their antibacterial activity as a disinfectant. These compounds were prepared by reacting triphenyltin(IV) hydroxide (1) with 4-aminobenzoic acid and 4-nitrobenzoic acid, respectively. Compound (2) was obtained as a yellow solid with a yield of 84.09% and compound (3) in the form of a white solid with a yield of 80.70%. These compounds were well characterized using UV-Vis spectrometry, FT-IR spectrometry and NMR spectroscopy. The bioactivity test as a disinfectant was tested against Salmonella typhosa and Staphylococcus aureus. The activity test was carried out by measuring the optical density (OD) of the tested compounds with concentration variations of 5x10-3, 1x10-3, and 5x10-4 M in methanol and 5% dimethyl sulfoxide (DMSO), commercial Wipol (2.5% pine oil) was used as a positive control with observations monitored at contact times of 0, 5, 10, and 15 minutes. The results showed that of both compounds were active against the two bacteria compared to the positive control with compound 3 found to be more active than compound 2.

show abstract

“…Bacterial resistance to antibiotics is a problem that has not been resolved until now (3,5,6). The E. coli resistants to chloramphenicol group of antibiotics and amoxicillin have long been reported (2,3,7,8).…”

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Separation Approach for Characterization of New Antibacterial Fractions from the Stem Roots Extracts of Archidendron jiringa

Noviany

Dicky

Andi

et al. 2021

Journal of the Turkish Chemical Society Section A: Chemistry

Self Cite

View full text Add to dashboard Cite

Infectious diseases caused by bacteria has become a global health issue, especially antibacterial drug resistance. The most serious concern with antibacterial resistance is that some bacteria became resistant to almost all antibacterial drugs, which makes them less effective. Archidendron jiringa is one of the most potent medicinal plants to be developed as a new source of antibacterial components. In current study, based on the antibacterial assay-guided approach, the separation of bioactive fractions of A. jiringa stem roots was carried out through several stages including isolation, fractionation, and characterization. The stages of isolation of secondary metabolites were conducted by gradually extraction followed by fractionation using chromatographic methods. The antibacterial potential of extracts was evaluated by the disc diffusion and microdilution methods employing the resazurin assay against one Gram-negative resistant bacteria, Escherichia coli, and one Gram-positive bacteria, Bacillus subtilis. Among three extracts obtained, ethyl acetate and methanol extracts demonstrated to be the most significant antibacterial effects, while no antibacterial activity was shown on the n-hexane extract. The fractionation of ethyl acetate extract led to the isolation of the most bioactive fractions (E2815 and E2816) with the MIC's values ranging of 12.5-25 µg/mL for both resistant bacteria. Due to the low amount, only the fraction E2816 was subjected to analysis by 1 H-NMR spectroscopy. The results exhibited that the bioactive fraction was obtained as a mixture of at least three major constituents. However, the purification of the bioactive fraction is required, to further clarify the antibacterial compound that can be utilized as a new promising antibacterial agent. The bioassay-guided separation approach and the dye resazurin as an indicator of the growth of bacteria are applied for the first time for the phytopharmacological investigation from this plant. The present study represented the most effective method for subsequent finding and isolation of potential novel antibacterial constituents from A. jiringa stem roots, in particular against the multi-drug resistant strains.

show abstract

Antibacterial Activity of Diphenyltin(IV) and Triphenyltin(IV) 3-Chlorobenzoate Againts Pseudomonas aeruginosa and Bacillus subtilis

Cited by 20 publications

References 15 publications

Sintesis, Karakterisasi, dan Uji Aktivitas Antibakteri Senyawa Organotimah(IV) 4-Nitrobenzoat

Sintesis, Karakterisasi, dan Uji Aktivitas Antibakteri Senyawa Organotimah(IV) 4-Nitrobenzoat

Synthesis, Characterization, and Comparison of Disinfectant Bioactivity Test of Two Triphenyltin(IV) Compounds

Bioassay-Guided Separation Approach for Characterization of New Antibacterial Fractions from the Stem Roots Extracts of Archidendron jiringa

Contact Info

Product

Resources

About