Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: Current state and perspectives

Li, Jianhui; Zhuang, Shaoling

doi:10.1016/j.eurpolymj.2020.109984

Cited by 479 publications

(268 citation statements)

References 102 publications

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“…In more recent work, COSs with an average MW of 17.2 kDa demonstrated a higher inhibition of Gram-negative bacteria [21]. Therefore, COSs' MW, DD, and PA play major roles in antimicrobial activity characteristics [48,49].…”

Section: Discussionmentioning

confidence: 95%

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

et al. 2021

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The global rise of infectious disease outbreaks and the progression of microbial resistance reinforce the importance of researching new biomolecules. Obtained from the hydrolysis of chitosan, chitooligosaccharides (COSs) have demonstrated several biological properties, including antimicrobial, and greater advantage over chitosan due to their higher solubility and lower viscosity. Despite the evidence of the biotechnological potential of COSs, their effects on trypanosomatids are still scarce. The objectives of this study were the enzymatic production, characterization, and in vitro evaluation of the cytotoxic, antibacterial, antifungal, and antiparasitic effects of COSs. NMR and mass spectrometry analyses indicated the presence of a mixture with 81% deacetylated COS and acetylated hexamers. COSs demonstrated no evidence of cytotoxicity upon 2 mg/mL. In addition, COSs showed interesting activity against bacteria and yeasts and a time-dependent parasitic inhibition. Scanning electron microscopy images indicated a parasite aggregation ability of COSs. Thus, the broad biological effect of COSs makes them a promising molecule for the biomedical industry.

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Section: Discussionmentioning

confidence: 95%

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

et al. 2021

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“…S. thermophillus culture in media MRS Broth media with chitosan oligosaccharide commercial at 0.1 mg/ml showed the highest stationary phase (225.3 x 10 8 cfu/ml). In accordance to Li & Zhuang (2020) chitosan has the higher antibacterial activity than chitosan oligomer. Moreover, the similar authors were also informed that the bactericidal effect of COS is higher in gram positive bacteria rather than gram negative bacteria.…”

Section: The Effect Of Chitooligosaccharide On the Growth Of S Thermmentioning

confidence: 84%

“…and S. thermophillus growth culture. Furthermore, Li & Zhuang. (2020) was also reported the mechanism of chitosan as antibacterial.…”

Section: Resultsmentioning

confidence: 99%

Potency of Chitosan and Chitooligochitosan (COS) as Prebiotics for Streptococcus thermophillus and Lactobacillus bulgaricus Probiotics

et al. 2021

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Lately, chitosan as a result of chitin deacetilation has known as potencial compound as food industry, pharmacy and environmental agents. The weakness of chitosan is the low water solubility and high viscosity. The size reduction by cutting the β-1, 4 glicosidic bond to improve the bioactivity is the alternative solution. This research aims to find out the addition of chitosan and COS for the Streptococcus thermophillus FNCC – 0041 and Lactobacillus bulgaricus FNCC – 0040 probiotics bacteria culture. S. thermophillus and L. bulgaricus were cultured in the MRS Broth media with addition of Commercial Chitosan (CC), Commercial Oligochitosan (COC), Self-production Chitosan (PC) and Self-production Oligochitosan (POC) in different doses (0.05; 0.1; and 0.2 mg.ml-1). Percentage DD on those treatments was similar. The spectra vibration of The FT-IR analysis of PC and POC were fit to the CC and COC. In chitosan treatments, the best growth of S. thermophilus was reached at 0.2 mg/mL PC, while in chitooligochitosan was from 0.20 mg/mL COC treatments, respectively. The addition of different type of chitosan have a significant effect (p<0.05) to the growth of S. thermophillus, but have not resulted the significant effect to the L. bulgaricus (p>0.05) growth. So, therefore the addition of chitosan and COS as prebiotics for the probiotics were in dose dependant manner. Compare to chitosan commercial, our chitosan production have a good potency to be developed.

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“…Chitosan (CS) is considered as a natural antibacterial compound, which can resist a variety of microorganisms, including bacteria, yeast, and mold (Li and Zhuang, 2020;. Low molecular weight CS can pass through the bacterial cell membrane and combine with negatively charged nucleic acid, while high molecular weight CS can adhere to the cell membrane and form a membrane on the surface of bacteria, thus hindering the transportation of nutrients (Li J. et al, 2016;Liu et al, 2020).…”

Section: Natural Polymersmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings

Luo

et al. 2020

Front. Bioeng. Biotechnol.

129

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At present, there are various wound dressings that can protect the wound from further injury or isolate the external environment in wound treatment. Whereas, infection and slow self-healing still exist in wound healing process. Therefore, it is urgent to develop an ideal wound dressing with good biocompatibility and strong antibacterial activity to promote wound healing. Bacterial cellulose is a kind of promising biopolymer because it can control wound exudate and provide a moist environment for wound healing. However, the lack of antibacterial activity limits its application. In this paper, the advantages of bacterial cellulose as wound dressings were introduced, and the preparation and research progress of bacterial cellulose-based antibacterial composites in recent years were reviewed, including adding antibiotics, combining with inorganic antibacterial agents or organic antibacterial agents. Finally, the existing problems and future development direction of bacterial cellulose-based antibacterial wound dressings were discussed.

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Antibacterial activity of chitosan and its derivatives and their interaction mechanism with bacteria: Current state and perspectives

Cited by 479 publications

References 102 publications

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Antimicrobial Activity of Chitosan Oligosaccharides with Special Attention to Antiparasitic Potential

Potency of Chitosan and Chitooligochitosan (COS) as Prebiotics for Streptococcus thermophillus and Lactobacillus bulgaricus Probiotics

Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings

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