Antibacterial Activity and Phytochemical Analysis of &lt;i&gt;Geranium homeanum&lt;/i&gt; Turez Leaves

Rahmawati, Fri; Bintang, Maria; Artika, I Made

doi:10.29244/cb.4.3.13-22

Cited by 14 publications

(17 citation statements)

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“…It was reported that phenol can interfere with the growth of Staphylococcus aureus through their acidic properties which allows them todenaturate proteins and can damage cell membranes 25 . Triterpenoids act on the cell wall by damaging the wall structure and can interfere with active transport in the cytoplasm of bacteria 26 .…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity Test of Jatropha multifida L. sap against Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus (MRSA) in vitro

Setyo Putri,

Purwanta,

Indiastuti

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Jatropha multifida L. is a plant that commonly used as a traditional treatment espescially for wounds. It has been proven that its sap had an antibacterial activity against Staphylococcus aureus. Staphylococcus aureus has developed resistant strains named MRSA (Methicillin-Resistant Staphylococcus aureus). Due to this resistance development, hopefully the sap of Jatropha multifida L. can also performed its antibacterial activity against MRSA. Objective: To determine the antibacterial activity of the sap of Jatropha multifida L. against Staphylococcus aureus and MRSA. Methods: A well-diffusion method was performed on several concentration: 100%, 50%, 25%, 12.5%, and 6.25%. From this method, the diameter of the inhibition zone produced by the sap was measured. Results: The average of inhibition zone diameter were 11.29 -16.00 mm for Staphylococcus aureus and the bigger zone 12.15 -17.61 mm for MRSA. Conclusion:Jatropha multifida L. had antibacterial activity against Staphylococcus aureus and MRSA. This plant showed higher antibacterial activity on MRSA than Staphylococcus aureus.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity Test of Jatropha multifida L. sap against Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus (MRSA) in vitro

Setyo Putri,

Purwanta,

Indiastuti

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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“…Triterpenoids dissolve readily in polar solvents, including water, owing to their composition. Geraniums' triterpene content has also been reported to be antibacterial 24 .…”

Section: Discussionmentioning

confidence: 99%

In vitro Test for Inhibition of Plasmodium falciparum 3D7 Parasites using Streptomyces hygroscopicus subsp. hygroscopicus Strain i18, Isolated from a Pineapple Farm in Lampung

Setyaningrum¹,

Nukmal²,

Aeny³

et al. 2021

J Pure Appl Microbiol

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Increasing natural ingredient awareness and utilization has created an increased demand for sources of natural medicinal ingredients, including sources of compound used to treat malaria. Streptomyces is a genus of prokaryote well recognized for its production of antibiotics and other pharmaceutically useful compound. This study aimed to assess the ability of unpurified fermentation metabolites to inhibit Plasmodium parasites. A strain of bacteria identified as Streptomyces hygroscopicus subsp. hygroscopicus strain i18 were isolated from pineapple fields in Lampung province, and was cultured and fermented on liquid synthetic Gause medium for 10 days. The supernatant was separated from the cells and extracted with ethyl acetate-methanol (1:1). Plasmodium falciparum 3D7 was used for antiplasmodial testing. Metabolites were tested qualitatively using a phytochemical approach. Saponins and triterpenoids were found to be present in the extract. Parasite inhibition as measured using probit analysis and yielded an IC50 value of 11.07 g.m/L. These findings suggest further examinations of this extract (e.g. assessment of off-target effects) are warranted.

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“…The terpenoid compounds action mechanism is by damaging the outer membrane, inner membrane and can also interact with membrane proteins with the help of alkaloids by inhibiting the formation of enzymes (esterase, DNA-, RNA-polymerase), inhibiting cell respiration. 12 produces an average inhibition diameter of 15.5 mm. The average inhibition diameter owned by amoxicillin is quite strong.…”

Section: Discussionmentioning

confidence: 99%

The effectivity of binahong (anredera cordifolia (ten.) steenis) leaves extract for growth inhibition of streptococcus mutans in oral cavity

Dohude

Ginting

2021

J Dentomaxillofac Sci

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Objective: This research was conducted to determine the effectiveness of binahong (anredera cordifolia (ten.) steenis) leaves extract in inhibiting the streptococcus mutans growth. Material and Methods:The study is true experimental laboratories with posttest-only control group design. The study sample used was Binahong leaves and streptococus mutans bacteria that were multiplied in Microbiology Laboratory of the Faculty of Pharmacy, Universitas Sumatera Utara. This study used seven treatment groups namely, 75%, 50%, 25%, 12.5%, 6.25% Binahong leaf extract, amoxicillin (positive control) and Dimethyl Sulfoxide (DMSO) (negative control). Testing the treatment group for the Streptococcus mutans was carried out using the Kirby-Bauer disk diffusion method with four repetitions. Extract was done by maceration using 96% ethanol solvent.Results: Indicate that the binahong leaves (anredera cordifolia (ten.) steenis) extract can inhibit the growth of streptococcus mutans which can be seen from the clear zone formed on paper discs that have been given binahong leaves extract with a concentration of 75%, 50%, 25%, 12, 5%, 6.25%, along with amoxicillin and dimethylsulfoxide/DMSO. The results also showed a significant difference in diameter of the inhibition zone from each treatment group (p <0.005). Conclusion: Binahong (anredera cordifolia (ten.) steenis) leaf extract has antibacterial ability because it can inhibit the growth of Streptococcus mutans in the oral cavity and compared to other concentrations, 75% concentration is more effective in inhibiting the growth of streptococcus mutans in the oral cavity.

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Antibacterial Activity and Phytochemical Analysis of <i>Geranium homeanum</i> Turez Leaves

Cited by 14 publications

References 0 publications

Antibacterial Activity Test of Jatropha multifida L. sap against Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus (MRSA) in vitro

Antibacterial Activity Test of Jatropha multifida L. sap against Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus (MRSA) in vitro

In vitro Test for Inhibition of Plasmodium falciparum 3D7 Parasites using Streptomyces hygroscopicus subsp. hygroscopicus Strain i18, Isolated from a Pineapple Farm in Lampung

The effectivity of binahong (anredera cordifolia (ten.) steenis) leaves extract for growth inhibition of streptococcus mutans in oral cavity

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