Antibacterial Activity and Metabolomics Profiling of Torch Ginger (Etlingera elatior Jack) Flower Oil Extracted Using Subcritical Carbon Dioxide (CO2)

Anzian, Aliaa; Muhialdin, Belal J.; Mohammed, Nameer Khairullah; Kadum, Hana; Marzlan, Anis Asyila; Sukor, Rashidah; Hussin, Anis Shobirin Meor

doi:10.1155/2020/4373401

Cited by 11 publications

(10 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1). The results were in agreement with those of Anzian et al [17], who reported that oil extracts of torch ginger (Etlingera elatior Jack) flower using subcritical carbon dioxide (CO 2 ) exhibited very strong antibacterial activity against S. aureus (14.50 ± 2.21 mm). Research by Susanti et al [18] showed that the 10 μL concentration of torch ginger flower essential oil could provide 6 mm inhibition in S. aureus bacteria.…”

Section: Antibacterial Activitysupporting

confidence: 92%

“…The EFs of torch ginger contained 19 compounds, with Dodecanoic acid (18.60%) being the most abundant (Table 1). The (E)-5-Tetradecene, 1-Tetradecyl acetate, Cyclotetradecane, Tetradecanoic acid, Cyclotetradecane, n-Hexadecanoic acid, Tricosane, Dodecanoic acid, and Dodecyl ester were similar to the previous reports [2,[17][18][20][21].…”

Section: Metabolites Profilessupporting

confidence: 89%

“…We identified several compounds in extracts and fractions of torch ginger, have also been previously reported such as Dodecanoic acid [2,17,20], n-Hexadecanoic acid [18,20], 1-Dodecanol [2,17,20], Tetradecene [20], 1-Decanol [17][18], Tetradecanoic acid [2,18,20], 1-Tetradecyl acetate [2], Acetic acid [22], Dodecene [22], 1,3-Propanediol [22], Cyclododecane [20], 9-Tetradecen-1-ol [18,20], Propanedioic acid [20], 13-Octadecenoic acid [20], 9,12-Octadecadienoic acid [20], Tricosane [20], Dodecane [20], and 1-Tetradecanol [18]. Hexane, chloroform, and ethyl acetate fractions containing some of these compounds have inhibitory activity against S. aureus.…”

Section: Metabolites Profilesmentioning

confidence: 71%

See 2 more Smart Citations

GC-MS Based Metabolite Profiling and Antibacterial Activity of Torch Ginger (Etlingera elatior) Flowers Extract

et al. 2022

View full text Add to dashboard Cite

Torch ginger (Etlingera elatior) flowers are well known for their antibacterial effects against Staphylococcus aureus, however, the active compounds are still unknown. The purpose of this study was to conduct GC-MS-based metabolite profiling of torch ginger flower and identify compounds correlated with its S. aureus antibacterial activity using Orthogonal Projection to Latent Structure (OPLS). Using the well diffusion method, the antibacterial activity of ethanol extract, hexane, chloroform, and ethyl acetate fractions with a concentration of 80 mg/mL were investigated. The ethyl acetate fraction inhibited S. aureus growth the most (diameter of inhibition zone, DIZ 13.00–13.20 mm), while the hexane (DIZ 9.55–10.05 mm) and chloroform (DIZ 10.00–11.00 mm) fractions had moderate inhibitory activity, but the ethanol extract had no antibacterial effect. Using OPLS analysis, the GC-MS metabolite profile of all extracts and fractions was linked with the profile of antibacterial activity. This analysis revealed that Dodecanoic acid, 5-Tetradecene, and n-Hexadecanoic acid were identified as the compounds that were significantly connected with antibacterial activity.

show abstract

Section: Antibacterial Activitysupporting

confidence: 92%

Section: Metabolites Profilessupporting

confidence: 89%

Section: Metabolites Profilesmentioning

confidence: 71%

See 1 more Smart Citation

GC-MS Based Metabolite Profiling and Antibacterial Activity of Torch Ginger (Etlingera elatior) Flowers Extract

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The oil of the torch ginger flower, extracted with subcritical carbon dioxide (CO2), has a lot of potential as a natural antibacterial agent in pharmaceutical and food applications. After 12 months of storage at 8°C, the extracted oil's antibacterial activity remained quite stable (Anzian et al, 2020). Preliminary study by Syafriana et al (2021) resulted that Staphylococcus epidermidis and Propionibacterium acnes can be inhibited by an ethanol extract of torch ginger flower.…”

Section: Antimicrobial Activitymentioning

confidence: 97%

Medicinal potential and health benefits of torch ginger (Etlingera elatior)

ISMAIL,

RIDZUAN

2023

Not Sci Biol

View full text Add to dashboard Cite

Indo-Pacific Region has a rich diversity of medicinal and aromatic plants. Torch ginger (Etlingera elatior) from the Zingiberaceae family in exemplary, is one of the valuable sources for condiment, ornamental and medicinal purposes. This perennial herb can be found growing in clumps of aromatic rhizomes with their distinctive inflorescences, borne on erect stalks and showy bracts. Their torch-like flowers are edible, usually appeared during the second year of cultivation and continuous harvesting is feasible for the flower production. The varieties of torch ginger with pink-color flowers are often cultivated compared to white and red flower varieties due to the market demand. Interestingly, almost every part of this herb produces certain percentages of beneficial phytochemicals. In this review, the botanical aspects of torch ginger as well as their progresses in usage and properties in different forms as fresh, extract and essential oils have been conversing with respect to their plant parts. Major compounds found in torch ginger are phenols, polyphenols, flavonoids and terpenoids. Those compounds correlate with the significant health benefits of torch ginger such as antioxidant, antimicrobial, antitumor, antihyperuricemic, antiallergic, cytotoxicity, antidiabetic as well as their cosmeceutical potential in skin care application. Moreover, the prominent pharmacological activities of this herb with particular attention to the chemical composition also have been uncovered, suggesting the substantial medicinal benefits of torch ginger.

show abstract

“…In Malaysia, particularly in Borneo, E. elatior has widely been used as a traditional remedy for stomachache, food poisoning, and gastric problems (Guzzo et al, 2020). The inhibitory activities of E. elatior extracts against Gram-positive bacteria including S. aureus have previously been reported (Chan et al, 2011;Anzian et al, 2020). However, the efficacy of E. elatior against the biofilm formation by S. aureus remains uncertain.…”

mentioning

confidence: 99%

Antibiofilm Efficacy and Mode of Action of Etlingera elatior Extracts Against Staphylococcus aureus

Hamdan,

Ross,

Jalil

et al. 2024

MAB

View full text Add to dashboard Cite

Staphylococcus aureus represents a major bacterial human pathogen that causes a wide variety of clinical manifestations. Various medicinal plants have been used to control its infection, however, the effect of Etlingera elatior on S. aureus biofilm is still uncertain. Thus, the objective of this study was to evaluate the antibacterial and antibiofilm efficacy of E. elatior extracts against S. aureus. Phytochemical screening was carried out to determine the presence of phenols, tannins, saponins, and alkaloids in different extracts (acetone, methanol, ethanol, and aqueous) of E. elatior. Antibacterial activities were determined by disk diffusion assay, minimum inhibitory concentration assay (MIC), and minimum bactericidal concentration assay (MBC) while antibiofilm activities were determined by crystal violet assay and Fourier-transform infrared (FTIR) spectroscopy. All the extracts were found to contain phenols, tannins, saponins, and alkaloids. Only acetone extract showed a high amount of saponins. Among all the extracts, acetone extract showed the widest inhibition zone (21.23±0.2 mm), lowest MIC (20 mg/mL), and lowest MBC (50 mg/mL) values. The acetone extract also showed the highest antibiofilm activities at all biofilm stages (6 hr: 12%-31%; 12 hr: 20%-36%; 18 hr: 27%-32%; 24 hr: 5%-46%). Further analysis with FTIR spectroscopy revealed spectral changes associated with proteins (1700–1400 cm-1), phospholipids, and polysaccharides (1300–700 cm-1) in S. aureus biofilm following the treatment with 200 mg/mL of E. elatior extracts. In conclusion, E. elatior is a potential source of antibacterial and antibiofilm agents to control S. aureus infections. Changes in the composition of proteins, phospholipids, and polysaccharides may mediate the biofilm inhibition by E. elatior extracts. The acetone extract of E. elatior may be useful for various applications such as antimicrobial topical cream and wound dressing.

show abstract

Antibacterial Activity and Metabolomics Profiling of Torch Ginger (Etlingera elatior Jack) Flower Oil Extracted Using Subcritical Carbon Dioxide (CO₂)

Cited by 11 publications

References 53 publications

GC-MS Based Metabolite Profiling and Antibacterial Activity of Torch Ginger (<i>Etlingera elatior</i>) Flowers Extract

GC-MS Based Metabolite Profiling and Antibacterial Activity of Torch Ginger (<i>Etlingera elatior</i>) Flowers Extract

Medicinal potential and health benefits of torch ginger (Etlingera elatior)

Antibiofilm Efficacy and Mode of Action of Etlingera elatior Extracts Against Staphylococcus aureus

Contact Info

Product

Resources

About