Antibacterial activity and antibiotic modulating potential of the essential oil obtained from Eugenia jambolana in association with led lights

Pereira, Nara Luana Ferreira; Aquino, Pedro Éverson Alexandre de; Júnior, José G.A.S.; Cristo, Janyketchuly S.; Filho, Marcos A. Vieira; Moura, Flávio F.; Ferreira, Najla M.N.; Silva, Maria K.N.; Nascimento, Eloiza Maria do; Correia, Fabrina M.A.; Cunha, Francisco Assis Bezerra da; Boligon, Aline Augusti; Coutinho, Henrique Douglas Melo; Ribeiro-Filho, Jaime; Matias, Edinardo Fágner Ferreira; Guedes, Maria Izabel Florindo

doi:10.1016/j.jphotobiol.2017.07.027

Cited by 32 publications

(28 citation statements)

References 17 publications

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“…In the case of both bacterial species, the number of colony-forming unites per milliliter was reduced; however, gram-positive bacteria were more susceptible to PDT than gram-negative ones, which is consistent with other literature [29,31]. Another study of combining aPDT with two fluoroquinolones (CIP and norfloxacin) was presented by Pereira et al [29]. This study demonstrated that irradiation of E. coli and S. aureus with blue or red light in the presence of CIP is more effective than antibiotic monotherapy.…”

Section: Discussionsupporting

confidence: 92%

“…The results were significant when CIP was administered before the aPDT treatment as well as when the CIP administration was followed by an aPDT. In the case of both bacterial species, the number of colony-forming unites per milliliter was reduced; however, gram-positive bacteria were more susceptible to PDT than gram-negative ones, which is consistent with other literature [29,31]. Another study of combining aPDT with two fluoroquinolones (CIP and norfloxacin) was presented by Pereira et al [29].…”

Section: Discussionsupporting

confidence: 82%

“…PDT is a method widely used in dermatology and periodontics, less frequently in ophthalmology, gastroenterology, or other medicine branches [21][22][23][24]. This method is also successfully used against gram-positive and gram-negative bacteria in in vitro studies [25][26][27][28][29][30][31]. However, it should be underlined that there are only a few reports describing the use of aPDT in urological infection [13,14].…”

Section: Discussionmentioning

confidence: 99%

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Photodynamic enhancement of the activity of antibiotics used in urinary tract infections

et al. 2019

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Photodynamic therapy (PDT) has been proven to kill different microbial cells. However, to our knowledge, none of the available reports describes the modulatory effect of this therapy on the antibacterial activity of antibiotics against Escherichia coli rods being the main causative agent of urinary tract infections (UTIs). Therefore, the aim of our study was to verify if the PDT can enhance the antibacterial activity of antibiotics recommended in the treatment of UTIs. An attempt to determine the optimal conditions of PDT to enhance the bactericidal activity of ciprofloxacin, amikacin, and colistin has been made. In order to find the optimal antimicrobial conditions, the efficacy of four protocols associated with the use of different energy doses (70 and 120 J/ cm 2 ) and chlorin e6 (Ce6) concentrations (50 and 100 μg/mL) has been verified. The antibacterial effect of combined PDT and antibiotics was assessed by the time-kill assay. The best results were achieved for Ce6 at a concentration of 100 μg/mL and the energy dose 120 J/cm 2 for bacterial suspensions treated with ciprofloxacin. Taken together, our results showed that PDT using Ce6 improves the antibacterial activity of antibiotics effectively inhibiting bacterial growth and being promising in the elimination of bacterial UTIs in humans.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Photodynamic enhancement of the activity of antibiotics used in urinary tract infections

et al. 2019

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“…The results obtained in the present study corroborate those described by Pereira et al [32]. Through the gaseous contact method, the authors observed a synergistic effect from the association of blue LED light with the essential oil of Eugenia jambolana and antibiotics against strains of Escherichia coli and Staphylococcus aureus.…”

Section: Modulating Effect Of Essential Oils In Association With Bluesupporting

confidence: 92%

Photoinduced Antibacterial Activity of the Essential Oils from Eugenia brasiliensis Lam and Piper mosenii C. DC. by Blue Led Light

Silva¹,

Castro²,

Dantas³

et al. 2019

Antibiotics

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The objective of this work was to evaluate the phytochemical composition and the antibacterial and antibiotic-modulating activities of the essential oils of Eugenia brasiliensis Lam (OEEb) and Piper mosenii C. DC (OEPm) singly or in association with blue LED (Light-emitting diode) light. The antibacterial and antibiotic-modulatory activities of the essential oils on the activity of aminoglycosides were evaluated to determine the minimum inhibitory concentration (MIC, μg/mL) in the presence or absence of exposure to blue LED light. The chemical analysis showed α-pinene and bicyclogermacrene as major constituents of OEPm, whereas α-muurolol was the main compound of OEEb. Both OEEb and OEPm showed MIC ≥ 512 μg/mL against the strains under study. However, the association of these oils with the blue LED light enhanced the action of the aminoglycosides amikacin and gentamicin. In conclusion, the association of aminoglycosides with the blue LED light and essential oils was effective against resistant bacteria.

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“…The authors concluded from their observation that it is possible to determine the importance of cAMP in antibiotic susceptibility and biofilm formation of E. coli by photo-manipulating the cellular cAMP level using BsPAC. Most recently, Pereira et al also reported the synergism between 470-nm aBL with ciprofloxacin or norfloxacin against E. coli and S. aureus (Pereira et al, 2017a; Pereira et al, 2017b). …”

Section: Synergism Of Antimicrobial Blue Light With Other Agentsmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

223

192

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As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400–470 nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed.

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Antibacterial activity and antibiotic modulating potential of the essential oil obtained from Eugenia jambolana in association with led lights

Cited by 32 publications

References 17 publications

Photodynamic enhancement of the activity of antibiotics used in urinary tract infections

Photodynamic enhancement of the activity of antibiotics used in urinary tract infections

Photoinduced Antibacterial Activity of the Essential Oils from Eugenia brasiliensis Lam and Piper mosenii C. DC. by Blue Led Light

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

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