Photodynamic enhancement of the activity of antibiotics used in urinary tract infections

Tichaczek−Goska, Dorota; Wojnicz, Dorota; Symonowicz, Krzysztof; Ziółkowski, Piotr; Hendrich, Andrzej B.

doi:10.1007/s10103-019-02730-7

Cited by 22 publications

(19 citation statements)

References 31 publications

(46 reference statements)

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“…E. coli is the best-known bacteria of the Enterobacteriaceae family [ 50 ]. Even though some serotypes of E. coli can cause serious disease, most strains are harmless and can only act as opportunistic pathogens [ 51 ].…”

Section: Results Of Studies On In Vitro Apdt Combined With Antimicrobial Agents Against Infectious Microorganism Of Skin and Soft Tissuesmentioning

confidence: 99%

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Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances

et al. 2021

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The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult.

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Section: Results Of Studies On In Vitro Apdt Combined With Antimicrobial Agents Against Infectious Microorganism Of Skin and Soft Tissuesmentioning

confidence: 99%

“…The combination of ciprofloxacin, amikacin, or colistin with aPDT using chlorin e6 improves the antibacterial activity of antibiotics against planktonic E. coli , being the best combination with ciprofloxacin [ 51 ].…”

Section: Results Of Studies On In Vitro Apdt Combined With Antimicrobial Agents Against Infectious Microorganism Of Skin and Soft Tissuesmentioning

confidence: 99%

Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances

et al. 2021

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“…Unlike antibiotics, which target a single major target, PDT targets a variety of bacterial cell structures and components. Hence PDT can reduce the risk of developing resistance of organisms exposed to it (Tichaczek-Goska et al, 2019).…”

Section: Mechanismmentioning

confidence: 99%

A Comprehensive Review on Current Progressions in Combating The Antimicrobial Resistance

Sain¹,

Manohar²,

Gowda³

2020

ijrps

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Anti-microbial resistance (AMR) is the ability of a microbe to resist the effect of antibiotics. It has become the most important cause of concern throughout the world. AMR may develop a variety of mechanisms, including resistance, weakness or due to a certain therapeutic failure. The three major causes of resistance were identified to be over usage of anti-microbials, over-prescription, increased agricultural usage. The mechanism which leads to the development of AMR were found to be Metabolic Inactive Persister cells biofilm formation, Swarming, Obligate intracellular microbes, Reduced uptake and efflux pumps, Modification of the antibiotic binding site, Production of competitive inhibitors. Research is still being carried out and few methods successfully delay or inhibit the progress of Resistance namely: Photodynamic therapy, which works on the principle of photosensitization, results in formation of ROS which destroy pathogenic cells, Vaccines, which strengthen the defence system to fight against foreign microorganisms efficiently, Antibiotic adjuvants, work by inhibiting any kind of mechanism related to the resistance increasing the drug’s antibacterial efficiency, Nano antibiotics which acts by interfering with the mechanisms for the development of the resistance and microfluidics give a better understanding of the bacteria and its superior antimicrobial susceptibility testing. Hence, in this review the above mechanisms of antimicrobial resistance as well the latest AMR combating strategies are been discussed.

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“…Various excellent reviews on PDDI have been published [ 32 , 65 – 77 ], including with a focus on the treatment of multi-resistant bacteria in planktonic suspensions or in biofilms [ 78 ], as well as fungi [ 79 ] and viruses [ 80 , 81 ]. Many efforts have been dedicated to the synthesis of photosensitizers and to new strategies for PDDI [ 62 , 64 , 66 , 67 , 82 , 83 ], including the combination with antimicrobials [ 32 , 84 , 85 ]. There is also an interesting literature on the use of blue light (400–450 nm) to excite endogenous photosensitizers that generate oxidative stress or to produce oxygen-independent DNA damage [ 86 ], but such approaches are intrinsically limited by the low penetration of blue light in human tissues.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic disinfection and its role in controlling infectious diseases

Aroso

Schaberle

Arnaut

et al. 2021

Photochem Photobiol Sci

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Photodynamic therapy is witnessing a revival of its origins as a response to the rise of multi-drug resistant infections and the shortage of new classes of antibiotics. Photodynamic disinfection (PDDI) of microorganisms is making progresses in preclinical models and in clinical cases, and the perception of its role in the clinical armamentarium for the management of infectious diseases is changing. We review the positioning of PDDI from the perspective of its ability to respond to clinical needs. Emphasis is placed on the pipeline of photosensitizers that proved effective to inactivate biofilms, showed efficacy in animal models of infectious diseases or reached clinical trials. Novel opportunities resulting from the COVID-19 pandemic are briefly discussed. The molecular features of promising photosensitizers are emphasized and contrasted with those of photosensitizers used in the treatment of solid tumors. The development of photosensitizers has been accompanied by the fabrication of a variety of affordable and customizable light sources. We critically discuss the combination between photosensitizer and light source properties that may leverage PDDI and expand its applications to wider markets. The success of PDDI in the management of infectious diseases will ultimately depend on the efficacy of photosensitizers, affordability of the light sources, simplicity of the procedures, and availability of fast and efficient treatments. Graphic abstract

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Photodynamic enhancement of the activity of antibiotics used in urinary tract infections

Cited by 22 publications

References 31 publications

Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances

Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances

A Comprehensive Review on Current Progressions in Combating The Antimicrobial Resistance

Photodynamic disinfection and its role in controlling infectious diseases

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