Antiamnesic potentiality of Argyreia speciosa (Burm.f) Boj. in mice

Habbu, Prasanna; Mahadevan, Kittappa M.; Shastry, R. A.; Chilakwad, S. R.

doi:10.4103/0973-8258.63881

Cited by 14 publications

(7 citation statements)

References 3 publications

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“…Previous work had already reported that this compound had a strong antibacterial activity, specifying that it was more active against Grampositive than Gram-negative bacteria. [15][16][17] Also, some other studies had demonstrated that quercetin had a good acute toxicity effect and a strong antioxidant effect when tested in vivo. [18,19] The latter effect was tested in rats and it showed that low concentration of the flavonoid was sufficient to determinate its metabolic profile.…”

Section: Discussionmentioning

confidence: 97%

Antibacterial, antioxidant and acute toxicity tests on flavonoids extracted from some medicinal plants

Akroum¹,

Bendjeddou²,

Satta³

et al. 2010

Int J Green Pharm

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Flavonoids are well-known for their many therapeutic and pharmaceutical effects. In this study, we tested the antibacterial activity of 11 flavonoids extracted from some medicinal plants by the agar diffusion method. Then, we measured their antioxidant activity using the DPPH (2,2'-diphenyl-1-picrylhydrazyl) radical assay and we also tested their acute toxicity effect on mice. The results showed that apigenin-7-O-glucoside was more active against the Gram-positive bacteria and quercetin was more active against the Gram-negative ones. Also, quercetin and diosmin showed the best antioxidant activity. Quercetin, apigenin-7-O-glucoside, luteolin-7-O-glucoside and luteolin-3'-O-glucuronide gave the best acute toxicity values. It can be concluded that quercetin was the most interesting compound for all the tested activities. Also, we observed that the presence or the absence of substitutions in flavonoids influenced significantly the results obtained, whereas the substitution type had a low impact.

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Section: Discussionmentioning

confidence: 97%

Antibacterial, antioxidant and acute toxicity tests on flavonoids extracted from some medicinal plants

Akroum¹,

Bendjeddou²,

Satta³

et al. 2010

Int J Green Pharm

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“…Sulfated flavonoids can present themselves as single‐ or multi‐sulfate esters, while rotonoid isoflavonoids are chemically biosynthesized from isoflavones and are characterized by a four‐ring chromanochromanone structure (Dixon, 1999) (Figure 2). Studies have described their anti‐inflammatory, antioxidant, antitumor, antimicrobial properties (Habbu et al, 2009; Ren et al, 2017; Teles et al, 2018), antidiabetic, and cytotoxic properties (Suthiphasilp et al, 2022). Treatment with the sulfated flavonoid persicarin (Per) (25), improved the survival rate and life expectancy of animals with sepsis (Kim et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

The effects of flavonoids in experimental sepsis: A systematic review and meta‐analysis

Rodrigues

Santana

Durço

et al. 2023

Phytotherapy Research

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Sepsis is a host's dysregulated immune response to an infection associated with systemic inflammation and excessive oxidative stress, which can cause multiple organ failure and death. The literature suggests that flavonoids, a broad class of secondary plant metabolites, have numerous biological activities which can be valuable in the treatment of sepsis. This study aimed to review the effects of flavonoids on experimental sepsis, focusing mainly on survival rate, and also summarizing information on its mechanisms of action. We searched in the main databases up to November 2022 using relevant keywords, and data were extracted and analyzed qualitatively and quantitatively. Thirty-two articles met the study criteria for review and 29 for metaanalysis. Overall, 30 different flavonoids were used in the studies. The flavonoids were able to strongly inhibit inflammatory response by reducing the levels of important pro-inflammatory mediators, for example, tumor necrosis factor-alpha and interleukin-1β, oxidative stress, and showed antibacterial and anti-apoptotic actions.The meta-analysis found an increase of 50% in survival rate of the animals treated with flavonoids. They appear to act as multi-target drugs and may be an excellent therapeutic alternative to reduce a number of the complications caused by sepsis, and consequently, to improve survival rate.

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“…Peroxidase activity was determined using the method described by Habbu et al [32]. To do this, 0.5 ml of homogenate or plasma was added to 1 ml of a solution of potassium iodide (10 mM) and 1 ml of sodium acetate (40 mM) was added.…”

Section: Determination Of Peroxidasementioning

confidence: 99%

Antityphoid and Antioxidant Activities of Leaf Extracts of Dracaena deisteliana Eng. (Dracaenaceae)

Feudjio,

Goka,

Djenguemtar

et al. 2023

IJTDH

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Salmonellosis is a major public health problem in developing countries where it is endemic. The genus Salmonella express the oxyR gene that codes for several proteins that allow them to resist free radicals. To investigate the antioxidant activity in vitro (aqueous and hydroethanolic extracts in vivo (of the 55% hydroethanolic extract)) of Dracaena deisteliana leaves in albino’s rats of Wistar strain previously infected with the Salmonella Typhi ATCC 6539 strain. The in vitro antioxidant activity of these extracts was determined by studying their anti-radical power with DPPH●, then their iron-reducing power and determining their flavonoids and total phenols content. The in vivo antioxidant activity was determined in plasma and tissues of albino’s rats of wistar strain aged between 8 and 10 weeks previously infected with Salmonella typhi ATCC 6539. These infected rats concurrently received daily doses of Dracaena deisteliana extract (10, 20 and 51.84 mg/kg) and ciprofloxacin (14 mg/kg) as positive control, for 15 days. At the end of the treatment period, the animals were sacrificed and blood, liver, kidney, heart, lung, spleen testis and ovaris were collected for evaluation of antioxidants parameters, which included malondialdehyde, nitric oxide, catalase and peroxidase, as well as biological responses. Regarding the in vitro antioxidant tests, the 55% hydroethanolic extract had the best IC50 (11.99 μg/ml). The iron reducing power of this extract was higher than the other extracts at 200 μg/ml. The highest levels of flavonoids and total phenols were obtained respectively with this extract. This extract (10, 20 and 51.84 mg/kg) cured the infected rats between the 8th and 12th day of treatment. The extract also significantly reduced blood malondialdehyde and nitric oxide levels, and significantly increased the activity of catalase and peroxidase in the infected rats. The results suggest that leaves extract of Dracaena deisteliana contains antisalmonella and antioxidant substances, which could be used for the treatment of typhoid fever and reduces the state of oxidative stress caused by Salmonella. Typhi during rat’s infection.

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Antiamnesic potentiality of Argyreia speciosa (Burm.f) Boj. in mice

Cited by 14 publications

References 3 publications

Antibacterial, antioxidant and acute toxicity tests on flavonoids extracted from some medicinal plants

Antibacterial, antioxidant and acute toxicity tests on flavonoids extracted from some medicinal plants

The effects of flavonoids in experimental sepsis: A systematic review and meta‐analysis

Antityphoid and Antioxidant Activities of Leaf Extracts of Dracaena deisteliana Eng. (Dracaenaceae)

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