Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha piperita L.

Inoue, Takuya; Sugimoto, Yukihiko; Masuda, Hideki; Kamei, Chiaki

doi:10.1248/bpb.25.256

Cited by 142 publications

(101 citation statements)

References 10 publications

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“…To date, many low-molecularweight polyphenols have been reported as anti-allergic substances that inhibited the degranulation process. [30][31][32][33][34][35] Some of these polyphenols are known to suppress classswitching from IgM to IgE in B cells or the expression of Fc"RI and subunits in mast cells. [36][37][38] Quince fruit has been reported to contain low-molecular-weight polyphenols such as caffeoylquinic acids (3-, 4-, and 5-caffeoylquinic acids and 3,5-dicaffeoylquinic acid), quercetin glycosides (quercetin-3-galactoside and quercetin-3-rutinoside), and kaempferol glycosides (kaempferol-3-glucoside and kaempferol-3-rutinoside) in the pulp, peel, and seeds.…”

Section: Discussionmentioning

confidence: 99%

Anti-Allergic Effect of a Hot-Water Extract of Quince (Cydonia oblonga)

Shinomiya

Hamauzu

Kawahara

2009

Bioscience, Biotechnology, and Biochemistry

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We examined the effect of a crude hot-water extract (HW) of quince (Cydonia oblonga Miller) fruit on type I allergy in vivo and in vitro. The oral administration of the quince HW-added diet to NC/Nga mice for 63 d showed a significant decrease in the development of atopic dermatitis-like skin lesions under conventional conditions. The concentration of IgE in the serum collected from mice fed with quince HW was also lowered in a dose-dependent manner. Moreover, we found that quince HW inhibited the release of -hexosaminidase from rat basophilic leukemia cell line RBL-2H3 after a 24-h treatment. The quince HW fraction of less than 3 kDa reduced the mRNA expression of the high-affinity IgE receptor (Fc"RI) subunit. These results suggest that quince HW had an inhibitory effect on type I allergy by suppressing IgE production and IgE-mediated degranulation.

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Section: Discussionmentioning

confidence: 99%

Anti-Allergic Effect of a Hot-Water Extract of Quince (Cydonia oblonga)

Shinomiya

Hamauzu

Kawahara

2009

Bioscience, Biotechnology, and Biochemistry

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“…The release percentage of histamine was calculated by the following equation. 49,50 Histamine release…”

Section: Mast Cell Sensitization By Compound 48/80 and Microscopic Obmentioning

confidence: 99%

Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice

Chakraborty¹,

Kar²,

Kumari³

et al. 2017

IJN

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Background Type I hypersensitivity is an allergic reaction characterized by the overactivity of the immune system provoked by normally harmless substances. Glucocorticoids, anti-histamines, or mast cell stabilizers are the choices of treatment for type I hypersensitivity. Even though these drugs have the anti-allergic effect, they can have several side effects in prolong use. Cedrol is the main bioactive compound of Cedrus atlantica with anti-tumor, anti-oxidative, and platelet-activating factor inhibiting properties. Methods In this study, the preparation and anti-anaphylactic effect of cedrol-loaded nanostructured lipid carriers (NLCs) were evaluated. NLCs were prepared using Compritol ® 888 ATO and triolein as lipid phase and vitamin E d -α-tocopherylpolyethyleneglycol 1000 succinate, soya lecithin, and sodium deoxycholate as nanoparticle stabilizers. Results The average diameter of cedrol-NLCs (CR-NLCs) was 71.2 nm (NLC-C 1 ) and 91.93 nm (NLC-C 2 ). The particle had negative zeta potential values of −31.9 mV (NLC-C 1 ) and −44.5 mV (NLC-C 2 ). Type I anaphylactoid reaction in the animal model is significantly reduced by cedrol and cedrol-NLC. This in vivo activity of cedrol resulted that cedrol suppressed compound 48/80-induced peritoneal mast cell degranulation and histamine release from mast cells. Furthermore, compound 48/80-evoked Ca 2+ uptake into mast cells was reduced in a dose-dependent manner by cedrol and cedrol-NLC. Studies confirmed that the inhibition of type I anaphylactoid response in vivo in mice and compound 48/80-induced mast cell activation in vitro are greatly enhanced by the loading of cedrol into the NLCs. The safety of cedrol and CR-NLC was evaluated as selectivity index (SI) with prednisolone and cromolyn sodium as positive control. SI of CR-NLC-C 2 was found to be 11.5-fold greater than both prednisolone and cromolyn sodium. Conclusion Administration of CR-NLC 24 hours before the onset of anaphylaxis can prevent an anaphylactoid reaction. NLCs could be a promising vehicle for the oral delivery of cedrol to protect anaphylactic reactions.

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“…Peppermint leaf and oil contain acetaldehyde, amyl alcohol, menthyl esters, limone, pinene, phellandrene, cadinene, pugelone, and dimethyl sulfide. Trace constituents include alpha-pinene, sabinene, terpinolene, ocimene, gammaterpinene, fenchene, alpha-and beta-thujone, citronellol, and other compounds (Nair, 2001;Inoue et al, 2002).…”

Section: Peppermint (Mentha Piperita)mentioning

confidence: 99%

“…Trace constituents include alphapinene, sabinene, terpinolene, ocimene, gamma-terpinene, fenchene, alpha-and beta-thujone, citronellol, and other compounds. Nair B, 2001;Inoue et al, 2002 Allergic reactions and conjunctivitis (Paulsen, 2002;De Smet, 2002) Warfarin Citochrome P450 (Segal and Pilote, 2006) Nettle Osteoarthritis. BPH Allergic rhinitis (hayfever) (Mittman, 1990;Lopatkin et al, 2005) Uterine-stimulant effects, it can induce abortion (Heinrich, 2003;Gagnier et al, 2006) None reported…”

Section: Pepermintmentioning

confidence: 99%

Risks and benefits of commonly used herbal medicines in Mexico

Rodríguez‐Fragoso

Reyes‐Esparza

Burchiel

et al. 2008

Toxicology and Applied Pharmacology

166

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In Mexico, local empirical knowledge about medicinal properties of plants is the basis for their use as home remedies. It is generally accepted by many people in Mexico and elsewhere in the world that beneficial medicinal effects can be obtained by ingesting plant products. In this review, we focus on the potential pharmacologic bases for herbal plant efficacy, but we also raise concerns about the safety of these agents, which have not been fully assessed. Although numerous randomized clinical trials of herbal medicines have been published and systematic reviews and meta-analyses of these studies are available, generalizations about the efficacy and safety of herbal medicines are clearly not possible. Recent publications have also highlighted the unintended consequences of herbal product use, including morbidity and mortality. It has been found that many phytochemicals have pharmacokinetic or pharmacodynamic interactions with drugs. The present review is limited to some herbal medicine that are native or cultivated in Mexico and that have significant use. We discuss the cultural uses, phytochemistry, pharmacological and toxicological properties of the following following plant species: Nopal (Opuntia ficus), Peppermint (Mentha piperita), Chaparral (Larrea divaricata), Dandlion (Taraxacum officinale), Mullein (Verbascum densiflorum), Chamomile (Matricaria recutita), Nettle or Stinging Nettle (Urtica dioica), Passionflower (Passiflora incarmata), Linden Flower (Tilia europea), and Aloa (Aloa vera). We conclude that our knowledge of the therapeutic benefits and risks of some herbal medicines used in Mexico is still limited and efforts to elucidate them should be intensified.

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Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha piperita L.

Cited by 142 publications

References 10 publications

Anti-Allergic Effect of a Hot-Water Extract of Quince (Cydonia oblonga)

Anti-Allergic Effect of a Hot-Water Extract of Quince (Cydonia oblonga)

Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice

Risks and benefits of commonly used herbal medicines in Mexico

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