Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz (Solanaceae) in rats

Nguelefack, Télesphore Benoît; Feumebo, Catherine B.; Ateufack, Gilbert; Watcho, Pierre; Tatsimo, Simplice Joel N.; Atsamo, Albert Donatien; Tane, Pierre; Kim, Albert

doi:10.1016/j.jep.2008.06.008

Cited by 54 publications

(27 citation statements)

References 31 publications

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“…In our study, HWE caused significant inhibition in the acidity (both total and free) with an elevation in gastric pH. Similar mode of action has also been reported in some other plant extracts (Umamaheswari et al, 2007;Nguelefack et al, 2008;Hiruma-Lima et al, 2009). The reduction of acidity of gastric juice mediated by HWE could be attributed to its antihistamine effect, because it is well established that antihistamine drugs like cimetidine which block H 2 receptors in the stomach, reduce the acidity of gastric juice (Laurence and Bennet, 1992).…”

Section: Discussionsupporting

confidence: 89%

“…Ethanol and indomethacin are commonly used for inducing ulcer in experimental rats (Umamaheswari et al, 2007;Nguelefack et al, 2008;Rao et al, 2008). Ethanol is one of the ulcerogenic agents that induces intense damage in gastric mucosa by promoting disturbances of mucosal microcirculation, ischemia and appearance of free radicals, endothelin release, degranulation of mast cells, inhibition of prostaglandins and decrease of gastric mucus production (Park et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

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Gastroprotective activity of Trichosanthes cucumerina in rats

Arawwawala

Thabrew

Arambewela

2010

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Gastroprotective activity of Trichosanthes cucumerina in rats

Arawwawala

Thabrew

Arambewela

2010

Journal of Ethnopharmacology

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“…Indomethacin was administered as the single oral dose (150 mg/kg) [40] dissolved in 5% sodium bicarbonate [41], and the rats were kept in cold stress for 2 h at a temperature of 3-5 ° C [42].…”

Section: Induction Of Severe Gastric Ulcers (Sgu)mentioning

confidence: 99%

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Sayed

Fahmy

Soliman

et al. 2016

Int J Pharm Pharm Sci

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Objective: The ethanolic extract of Vitis vinifera leaves (VVE) (500 mg/kg body weight), ranitidine (50 mg/kg body weight) and both of them were tested for their gastroprotective and curative effects against the incidence of peptic ulcer. Methods:The antiulcer effects of VVE were investigated using a combination of indomethacin and cold-stress for 2h. To ascertain the mechanism of action of VVE, its protective and curative effects were studied on gastric volume, gastric juice acidity, ulcer index and malondialdehyde (MDA), glutathione (GSH), catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO) activities of both stomach and duodenum of rats. Moreover, histopathological effects on stomach and duodenum were determined. Results:The antioxidant activity of VVE was demonstrated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) test. VVE was found to reduce the ulcer index, gastric volume and the level of gastric juice acidity. Also, VVE showed gastroprotective and curative activities mainly through improvement of antioxidant status and decreasing lipid peroxidation accompanied with amelioration of both stomach and duodenum architectures. Conclusion:The prophylactic and curative effects of VVE proved to be effective in preventing gastric and duodenal ulceration which may be probably due to its antioxidant and anti-acid secretory effects.

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“…The fruits of S. torvum are edible and traditionally used for the treatment of abscesses, jigger wounds, skin infections and athlete's foot [6]. Pharmacological studies revealed antiviral [7], immunosecretory [8], antioxidant [9], analgesic, anti-inflammatory [10] and antiulcerogenic activities [11]. Chemical constituents reported from this fruit include triacontane derivatives [12,13], chlorogenone and neochlorogenone [14], isoflavonoid sulfate and steroidal glycosides [7,15], 22-b-O-spirostanol oligoglycosides [16], 26-b-O-glucosidase [17]; methyl caffeate isolated from S. torvum showed a-glucosidase inhibition activity [18].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antimycobacterial Activities of Methyl Caffeate Isolated from Solanum torvum Swartz. Fruit

Balachandran¹,

Duraipandiyan

Al-Dhabi

et al. 2012

Indian J Microbiol

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Solanum torvum Swartz. (Solanaceae) fruit is traditionally used for the treatment of bacterial and fungal infections. The methanolic extract was subjected to activity guided fractionation by column chromatography over silica gel. The structure of the compound was elucidated using physical and spectroscopic data. The antimicrobial activity was screened using five Gram-positive bacteria, six Gramnegative bacteria, seven clinical isolates and four fungi. Antimycobacterial activity was screened against two Mycobacterium strains. The zone of inhibition by methyl caffeate ranged from 0 to 22 mm. The lowest minimum inhibitory concentration (MIC) values of methyl caffeate were: 50 lg/ml against P. vulgaris, 25 lg/ml against K. pneumoniae (ESBL-3971), 8 lg/ml against M. tuberculosis (H 37 Rv) and 8 lg/ml against M. tuberculosis (Rif R ). Methyl caffeate showed moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate can be evaluated further for drug development.

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Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz (Solanaceae) in rats

Cited by 54 publications

References 31 publications

Gastroprotective activity of Trichosanthes cucumerina in rats

Gastroprotective activity of Trichosanthes cucumerina in rats

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Antimicrobial and Antimycobacterial Activities of Methyl Caffeate Isolated from Solanum torvum Swartz. Fruit

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