Gastroprotective activity of Trichosanthes cucumerina in rats

Arawwawala, L.D.A.M.; Thabrew, M.I.; Arambewela, L.S.R.

doi:10.1016/j.jep.2009.11.026

Cited by 46 publications

(41 citation statements)

References 32 publications

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“…Histopathological studies were also performed which showed that hot water extract of T. cucumerina significantly reduced the gastric ulcerative lesions and perforations in groups pretreated with plant extract. Phytochemical screening of plant extract showed the presence of active constituents including alkaloids, saponins polyphenols, tannins and flavonoids which might participate in the antiulcer activity of plant (Arawwawala et al, 2009). …”

Section: Trichosanthes Cucumerinamentioning

confidence: 99%

Medicinal plants with gastroprotective potential

Majeed¹,

Khaliq²,

Aslam³

et al. 2015

Bangladesh J Pharmacol

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<p class="Abstract">Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for peptic ulcer disease. Histamine receptor blockers and proton pump inhibitors are most prominent therapies in the treatment of peptic ulcer. However, severe adverse effects of NSAIDs have been reported. Therefore, focus is now diverted towards herbal formulations of medicinal plants for the treatment of ulcer. Plants contain different phytoconstituents which are responsible for increasing defensive mechanisms of body against peptic ulcer. The current review focuses on the commonly used gastroprotective plants as antiulcer agents.</p><p> </p>

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Section: Trichosanthes Cucumerinamentioning

confidence: 99%

Medicinal plants with gastroprotective potential

Majeed¹,

Khaliq²,

Aslam³

et al. 2015

Bangladesh J Pharmacol

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“…Study demonstrated that orally given 750 mg/kg body weight of trichosanthes cucumerina extract induced an 88% reduction in the numbers of haemorrhagic lesions caused by indomethacin in rats. The efficacy was comparable to that induced by conventional drug, cimetidine (100 mg/kg) (Arawwawala et al, 2010). Likewise, asparagus racemosus Willd is a common vegetable.…”

Section: Efficacymentioning

confidence: 55%

Anti-Ulcerogenic Efficacy and Mechanisms of Edible and Natural Ingredients in Nsaid-Induced Animal Models

Man

2017

Afr J Tradit Complement Altern Med

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Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. This paper reviews the efficacy and safety of edible natural ingredients in preventing the development of gastric ulcer induced by NSAIDs in animal models. Methods: A systematic literature search was conducted on PubMed, using the terms "herbal medicines" and "gastric ulcer", "herbal medicines" and "peptic ulcer", "food" and "peptic ulcer", "food" and "gastric ulcer", "natural ingredient" and "peptic ulcer", "natural ingredient" and "gastric ulcer", "alternative medicine" and "peptic ulcer", "alternative medicine" and "gastric ulcer", "complementary medicine" and "peptic ulcer", "complementary medicine" and "gastric ulcer" in papers published in English between January 1, 1960 and January 31, 2016, resulting in a total of 6146 articles containing these terms. After exclusion of studies not related prevention, not in NSAID model or using non-edible natural ingredients, 54 articles were included in this review.Results: Numerous studies have demonstrated that edible natural ingredients exhibit antiulcerogenic benefit in NSAIDinduced animal models. The mechanisms by which edible, ingredient-induced anti-ulcerogenic effects include stimulation of mucous cell proliferation, antioxidation, inhibition of gastric acid secretion, as well as inhibition of H(+), K(+)-ATPase activities. Utilization of edible, natural ingredients could be a safe, valuable alternative to prevent the development of NSAID-induced gastric ulcer, particularly for the subjects who are long-term users of NSAIDs.

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“…Monoecious, male flowers in axillary racemes, peduncles 5-115 cm long, bearing [8][9][10][11][12][13][14][15] flowers near the apex, female flowers axillar, solitary. [2] www.wjpps.com Vol 6, Issue 5, 2017.…”

Section: Flowersmentioning

confidence: 99%

“…Increasing the protective mucus layer, decreasing the acidity of the gastric juice and antihistamine activity. [11] www.wjpps.com …”

Section: Gastro-protective Activitymentioning

confidence: 99%