Antimicrobial and Antimycobacterial Activities of Methyl Caffeate Isolated from Solanum torvum Swartz. Fruit

Abstract

Solanum torvum Swartz. (Solanaceae) fruit is traditionally used for the treatment of bacterial and fungal infections. The methanolic extract was subjected to activity guided fractionation by column chromatography over silica gel. The structure of the compound was elucidated using physical and spectroscopic data. The antimicrobial activity was screened using five Gram-positive bacteria, six Gramnegative bacteria, seven clinical isolates and four fungi. Antimycobacterial activity was screened against two Mycobacterium strains. The zone of inhibition by methyl caffeate ranged from 0 to 22 mm. The lowest minimum inhibitory concentration (MIC) values of methyl caffeate were: 50 lg/ml against P. vulgaris, 25 lg/ml against K. pneumoniae (ESBL-3971), 8 lg/ml against M. tuberculosis (H 37 Rv) and 8 lg/ml against M. tuberculosis (Rif R ). Methyl caffeate showed moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate can be evaluated further for drug development.

In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit

“…2). The identity of the compound was confirmed by comparison of the physical and spectroscopic data (IR, 1 HNMR, 13 CNMR and MS) with those reported in the literature [39].…”

In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives

“…This alarming situation highlights the urgent need to discover new antimalarial molecules. Natural phenolic compounds, commonly found in various plants, and some of their simple esters are known for several biological activities, such as anti‐inflammatory, antioxidant, anti‐diabetic, anti‐carcinoma, antibacterial and immunomodulatory . Among phenolic metabolites, caffeic acid and derivatives (such as chlorogenic) are the most frequently found and could be present in high quantities in some plants used as antimalarial traditional medicines, but also in foods (coffee beans, thyme, mint, wine, several fruits and vegetables…) …”

Anti-neuroinflammatory and NQO1 inducing activity of natural phytochemicals from Coreopsis tinctoria

“…By comparing their physical and spectroscopic data with those reported in the literature, compounds 1-7, 17-26 were identified as 3-O-caffeoyl quinic acid butyl ester (1) (Fan, Zhang, Zhou, Gesang, & Huang, 2011), 3-O-caffeoyl quinic acid methyl ester (2) (Xiang, Li, Zhang, Li, & Yao, 2007), methyl-phydroxycinnamate (5) (Ma, Wang, Yan, & Hao, 2008), methyl caffeate (6) (Balachandran et al, 2012), p-coumaric acid methyl ester-4-O-β-D-glucopyranoside (7) (Luyengi et al, 1993), quercetin (17) (Huang et al, 2006), maritimein (23) (Sashida et al, 1991), β-amyrin (24), β-sitosterol (25) and daucosterol (26). The physical and spectroscopic data, which were not shown in the manuscript, have been supplied in the supporting information.…”