Anti-tumor activity of grape juice concentrate in the rat tongue two-stage initiation–promotion protocol induced by 4-nitroquinoline 1-oxide

Jesus, Gustavo Protasio Pacheco de; Ribeiro, Flávia Andressa Pidone; Moura, Carolina Foot Gomes de; Gollucke, Andréa Pitelli Boiago; Oshima, Celina Tizuko Fujiyama; Ribeiro, Daniel Araki

doi:10.3109/15376516.2014.881944

Cited by 16 publications

(12 citation statements)

References 42 publications

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“…CTRL and Cd groups were treated with drinking water by gavage during the same experimental period. The grape juice group was not included into this experimental design because our research group has evaluated the protective potential of grape juice under different paradigms and the results have revealed that animals treated with grape juice only did not change such biological parameters investigated (Pires et al 2013;Paiotti et al 2013;de Jesus et al 2014).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Antimutagenic and antigenotoxic potential of grape juice concentrate in blood and liver of rats exposed to cadmium

Moura

Ribeiro

Jesus

et al. 2014

Environ Sci Pollut Res

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The aim of this study was to evaluate the antimutagenic and antigenotoxic potential of grape juice concentrate in rodent organs exposed to cadmium chloride intoxication. A total of 15 Wistar rats were distributed into three groups (n = 5), as follows: control group (CTRL; nontreated group), cadmium group (Cd), and cadmium-grape juice group (Cd + GJ). Exposed animals received intraperitoneal injection of cadmium chloride (1.2 mg/kg body weight) diluted in water and, after 15 days, Cd + GJ group received grape juice concentrate for 15 days, by gavage (0.8 mL, 1.18 mg of polyphenols kg(-1) day(-1)). Grape juice concentrate was able to decrease genotoxic effects induced by cadmium in peripheral blood and liver cells as depicted by single cell gel (comet) and micronucleus assays. A decrease for anti-8-hydroxy-20-deoxyguanosine (8OHdG) expression in hepatocytes of animals exposed to cadmium and treated with grape juice concentrate was also detected. Higher CuZn-SOD activity was observed in liver cells of the Cd + GJ group. No remarkable differences were seen regarding Mn-SOD activity among groups. Taken together, our results demonstrate that grape juice concentrate was able to exert antimutagenic and antigenotoxic activities in blood and liver cells of rats exposed to cadmium.

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Section: Animals and Experimental Designmentioning

confidence: 99%

Antimutagenic and antigenotoxic potential of grape juice concentrate in blood and liver of rats exposed to cadmium

Moura

Ribeiro

Jesus

et al. 2014

Environ Sci Pollut Res

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“…Also, there is meager information on the diversity of beneficial compounds of muscadine grapes. The variety in structure and phytochemical composition indicate that these compounds may have a potential anticancer activity by acting on various cellular processes linked to tumor development (34). Therefore, in the present study, the antioxidant/anticancer activity of extracts from a wide array of genotypes from muscadine grapes was investigated in TNBC cells.…”

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confidence: 99%

The Anticancer and Antioxidant Effects of Muscadine Grape Extracts on Racially Different Triple-negative Breast Cancer Cells

et al. 2019

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Background/Aim: Triple-negative breast cancer (TNBC) is the most aggressive subtype, predominant in African American women. In this study, the antioxidant/anticancer activity of muscadine grape extracts and the role of their phenolic and flavonoid contents in exerting these properties were investigated in TNBC cells. Materials and Methods: Berry extracts from muscadine genotypes were investigated for total phenolic content (TPC), total flavonoid content (TFC), antioxidant capacity, and anticancer effects using breast cancer cell lines, representing Caucasians and African Americans. Results: The antioxidant activity was associated with high TPC content. Extracts showed cytotoxicity up to 78.6% in Caucasians and 90.7% in African American cells, with an association with high antioxidant capacity. There was a strong correlation between TPC and anticancer/antioxidant activities. Conclusion: The anticancer and antioxidant effects of muscadine grapes are attributed to the TPC of extracts, which showed a stronger positive correlation with growth inhibition of African American breast cancer cells compared to Caucasians.

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“…Polyphenols including flavonoids and tannins are the most common bioactive compounds found in M. caesalpi-niifolia. Such agents are able to inhibit tumour development in vivo and in vitro [16][17][18]. This is because polyphenols contain high polarity, and high solubility in polar solvent [19].…”

Section: Discussionmentioning

confidence: 99%

The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

et al. 2017

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The aim of this study was to evaluate the preventive and/or protective action of Mimosa caesalpiniifolia (M. caesalpiniifolia) following experimental colitis in rats. The rats were randomized into ten groups (n=10 per group), as follows: G1 - Sham group:; G2 - TNBS group; G3, G4 -colitis and treated with hydroalcoholic extract of M. caesalpiniifolia 250 mg/kg/day after and before/after inducing colitis, respectively; G5, G6 - colitis and treated with hydroalcoholic extract of M. caesalpiniifolia at 125 mg/kg/day after and before/after inducing colitis respectively; G7,G8 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively; G9,G10 - colitis and treated with ethylacetate fraction of M. caesalpiniifolia at 50 mg/kg/day after and before/after inducing colitis, respectively. Rats treated with hydroalcoholic extract of M. caesalpiniifolia for both doses showed lower tissue damage in the distal colon. Ethylacetate fraction was effective at the highest dose only when administrated after inducing colitis. A downregulation of COX-2 was detected to rats suffering colitis and treated with M. caesalpiniifolia at high dose. On the other hand, TNF-alpha immunoexpression decreased in groups treated with M. caesalpiniifolia at low dose after inducing colitis. In summary, our results suggest that M. caesalpiniifolia attenuated the lesions of the colon, reduced inflammation, and modulates the expression of COX-2 and TNF-α during chronic colitis induced by TNBS when using for therapeutic purposes on a dose-dependent manner.

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Anti-tumor activity of grape juice concentrate in the rat tongue two-stage initiation–promotion protocol induced by 4-nitroquinoline 1-oxide

Cited by 16 publications

References 42 publications

Antimutagenic and antigenotoxic potential of grape juice concentrate in blood and liver of rats exposed to cadmium

Antimutagenic and antigenotoxic potential of grape juice concentrate in blood and liver of rats exposed to cadmium

The Anticancer and Antioxidant Effects of Muscadine Grape Extracts on Racially Different Triple-negative Breast Cancer Cells

The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression

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