Anti-tubercular Activity of Ruthenium (II) Complexes with Polypyridines

Abstract

A series of nine polypyridyl-ruthenium (II) complexes (N-ligands ¼ 2,2 0 -bipyridines; 2,2 0 -6 0 ,2 0 -terpyridines, di-alkyloxy-2, 2 0 -6,2-bipyridine-3,3 0 -di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1-10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.

Novel Mononuclear Ruthenium(II) Compounds in Cancer Therapy

“…transferrin and albumin) is believed to contribute to the general low toxicity and excellent cytotoxicity of ruthenium complexes (Ang and Dyson, 2006). Many of biological properties have been attributed to ruthenium complexes, for example: antitumor activity (Dyson, 2007;Bruijnincx and Sadler, 2009;Süss-Fink, 2010;Sreekanth et al, 2010;Govender et al, 2011), antioxidant activity (Paula et al, 2005), antinociceptive (Cristiano et al, 2008), antitubercular activity (Hadda et al, 2009) and immunomodulatory activity (Newcomb et al, 2003). In a recent article, we have proven that the above test compounds were shown significant antioxidant potentiality (Shyam et al, 2012).…”

Metal-based antibacterial and antifungal sulfonamides: synthesis, characterization, and biological properties

“…Recently, it is reported[35] that the change in the coordination sphere of the metal center upon substituting chloro, carbonyl, or acetonitrile ligands by two aquo-ligands changes efficiently the anti-tubercular activity The combined evidence points to a mechanism where the oxo-bridged dimer is hydrolyzed to a monomeric Ru(III) complex that is capable of oxidizing DNA to affect strand scission. These results could be compared with those for [Ru(tpy)(bpy)] 2?…”

Transition metal diamine complexes with antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA)

“…9,10 Others have also reported on the cytotoxic behavior of different variants of half-sandwich compounds. 13 The antimicrobial properties of the Ag + ion have long been known. 13 The antimicrobial properties of the Ag + ion have long been known.…”