Anti-Trichomonas vaginalis activity of Hypericum polyanthemum extract obtained by supercritical fluid extraction and isolated compounds

Cargnin, Simone Tasca; Vieira, Patrícia de Brum; Cibulski, Samuel Paulo; Cassel, Eduardo; Vargas, Rubem Mário Figueiró; Montanha, Jarbas Alves; Roehe, Paulo Michel; Tasca, Tiana; Poser, Gilsane Lino von

doi:10.1016/j.parint.2012.10.006

Cited by 32 publications

(16 citation statements)

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“…41 A utilização potencial de extratos no tratamento da tricomoníase pode ser relevante, já que existem alguns variações de T. vaginalis que podem ser resistentes ao tratamento convencional com metronidazol. [41][42][43] Dessa forma, um estudo que avaliou a atividade antiparasitária do extrato de Hypericum polyanthemum frente a T. vaginalis resistentes verificou que houve redução da motilidade do parasita com os extratos testados, porém não de forma relevante. 42 Os extratos de Commiphora molmol e Punica granatum também foram capazes de inviabilizar cepas de T. vaginalis resistentes a metronidazol.…”

Section: Resultsunclassified

“…[41][42][43] Dessa forma, um estudo que avaliou a atividade antiparasitária do extrato de Hypericum polyanthemum frente a T. vaginalis resistentes verificou que houve redução da motilidade do parasita com os extratos testados, porém não de forma relevante. 42 Os extratos de Commiphora molmol e Punica granatum também foram capazes de inviabilizar cepas de T. vaginalis resistentes a metronidazol. 39 Esses estudos apontam que a utilização de extratos vegetais pode ser uma alternativa quando existir resistência ao metronidazol.…”

Section: Resultsunclassified

“…39 Esses estudos apontam que a utilização de extratos vegetais pode ser uma alternativa quando existir resistência ao metronidazol. [41][42][43] Em conclusão, extrato de folha de videira convencional de V. labrusca demonstrou ter ação antiparasitária para trofozoítos de T. vaginalis. Por ser um estudo preliminar e in vitro, são necessários novos estudos experimentais e clínicos para verificar a especificidade da ação desses extratos e as concentrações adequadas para combater a tricomoníase.…”

Section: Resultsunclassified

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Atividade citotóxica do extrato de Vitis labrusca em culturas de Trichomonas vaginalis

et al. 2014

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Section: Resultsunclassified

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Atividade citotóxica do extrato de Vitis labrusca em culturas de Trichomonas vaginalis

et al. 2014

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“…Cargnin, Vieira [11] found that uliginosin B and three benzopyrans (Fig. 2) isolated from Hypericum polyanthenum, a Brazilian native plant, had anti-T-vaginalis activity that was associated with damage to the cell membrane (> 90% release of lactic dehydrogenase, LDH).…”

Section: Benzopyran Hp1 and Uliginosin Bmentioning

confidence: 99%

Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review

Friedman

Tam

Cheng

et al. 2020

BMC Complement Med Ther

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Human trichomoniasis, caused by the pathogenic parasitic protozoan Trichomonas vaginalis, is the most common non-viral sexually transmitted disease that contributes to reproductive morbidity in affected women and possibly to prostate cancer in men. Tritrichomonas foetus strains cause the disease trichomoniasis in farm animals (cattle, bulls, pigs) and diarrhea in domestic animals (cats and dogs). Because some T. vaginalis strains have become resistant to the widely used drug metronidazole, there is a need to develop alternative treatments, based on safe natural products that have the potential to replace and/or enhance the activity of lower doses of metronidazole. To help meet this need, this overview collates and interprets worldwide reported studies on the efficacy of structurally different classes of food, marine, and medicinal plant extracts and some of their bioactive pure compounds against T. vaginalis and T. foetus in vitro and in infected mice and women. Active food extracts include potato peels and their glycoalkaloids α-chaconine and α-solanine, caffeic and chlorogenic acids, and quercetin; the tomato glycoalkaloid α-tomatine; theaflavin-rich black tea extracts and bioactive theaflavins; plant essential oils and their compounds (+)-α-bisabolol and eugenol; the grape skin compound resveratrol; the kidney bean lectin, marine extracts from algae, seaweeds, and fungi and compounds that are derived from fungi; medicinal extracts and about 30 isolated pure compounds. Also covered are the inactivation of drug-resistant T. vaginalis and T. foetus strains by sensitized light; anti-trichomonad effects in mice and women; beneficial effects of probiotics in women; and mechanisms that govern cell death. The summarized findings will hopefully stimulate additional research, including molecular-mechanism-guided inactivations and human clinical studies, that will help ameliorate adverse effects of pathogenic protozoa.

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“…A wide variety of phloroglucinols have been characterized in Hypericum species from southern Brazil with established antidepressant‐like and antinociceptive activities. In addition to these activities in central nervous system, studies have already demonstrated the antiparasitic activities of lipophilic Hypericum extracts and of isolated compounds in T. vaginalis and L. amazonensis …”

Section: Introductionmentioning

confidence: 99%

The anti‐Trichomonas vaginalis phloroglucinol derivative isoaustrobrasilol B modulates extracellular nucleotide hydrolysis

et al. 2017

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Trichomonas vaginalis causes trichomoniasis, a neglected sexually transmitted disease. Due to severe health consequences and treatment failure, new therapeutic alternatives are crucial. Phloroglucinols from southern Brazilian Hypericum species demonstrated anti-T. vaginalis and anti-Leishmania amazonensis activities. The modulation of biochemical pathways involved in the control of inflammatory response by ectonucleotidases, NTPDase, and ecto-5'-nucleotidase represents new targets for combating protozoa. This study investigated the activity of phloroglucinol derivatives of Hypericum species from southern Brazil against T. vaginalis as well as its ability on modulating parasite ectonucleotidases and, consequently, immune parameters through ATP and adenosine effects. Phloroglucinol derivatives screening revealed activity for isoaustrobrasilol B (IC 38 μm) with no hemolytic activity. Although the most active compound induced cytotoxicity against a mammalian cell lineage, the in vivo model evidenced absence of toxicity. Isoaustrobrasilol B significantly inhibited NTPDase and ecto-5'-nucleotidase activities, and the immune modulation attributed to extracellular nucleotide accumulation was evaluated. The production of ROS and IL-6 by T. vaginalis-stimulated neutrophils was not affected by the treatment. Conversely, IL-8 levels were significantly enhanced. The associative mechanism of trophozoites death and ectonucleotidases modulation by isoaustrobrasilol B may increase the susceptibility of T. vaginalis to host innate immune cell like neutrophils consequently, contributing to parasite clearance.

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Anti-Trichomonas vaginalis activity of Hypericum polyanthemum extract obtained by supercritical fluid extraction and isolated compounds

Cited by 32 publications

References 30 publications

Atividade citotóxica do extrato de <i>Vitis labrusca</i> em culturas de <i>Trichomonas vaginalis</i>

Atividade citotóxica do extrato de <i>Vitis labrusca</i> em culturas de <i>Trichomonas vaginalis</i>

Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review

The anti‐Trichomonas vaginalis phloroglucinol derivative isoaustrobrasilol B modulates extracellular nucleotide hydrolysis

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