Anti-stress Activity of A Bioflavanoid: Quercetin from Euphorbia hirta

Tiwari, Neha; Mishra, Abha; Bhatt, Ganesh; Chaudhary, Anurag

doi:10.9734/bjpr/2015/16143

Cited by 10 publications

(9 citation statements)

References 16 publications

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“…Therefore, it is required to enhance the adaptability of human beings to stressful conditions. Synthetic drugs cannot use at broad spectrum due to their higher cost and side effect associated with them, so the researchers looking for alternative methods like Yoga, Herbal medicines [21].…”

Section: Discussionmentioning

confidence: 99%

Neuropharmacological Screening, Anti-Stress Activity, and Toxicity Studies of Standardized Extract of the Seeds of Celastrus Paniculatus Willd

Singh¹,

Upadhyay‬²,

Sirbaiya³

2021

Asian J Pharm Clin Res

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Objective: Celastrus paniculatus Willd, family Celastraceae is an important medicinal plant distributed all over India. Due to the presence of antioxidative polyphenols in C. paniculatus Willd have received much attention for health-promoting properties by scavenging the free radicals, the purpose of this study is to understand neuropharmacological, anti-stress activity, and toxicity studies of standardized seeds extract of “C. paniculatus Willd. Methods: The sun dried C. paniculatus Willd seeds were collected and extracted with ethanol by maceration. Then, the ethanolic extract was subjected to phytochemical screening. The acute toxicity of the ethanolic extract of C. paniculatus was observed as per the Organization for Economic Co-operation and Development guideline no. 423. Neuropharmacological and anti-stress effects were analyzed and evaluated by using physical stress models such as Swimming endurance test, Anoxic tolerance test, Tail suspension test (TST), and Elevated plus maze test. For this study, Swiss albino mice (20–30 g) were divided into five groups of six animals each. Distilled water administered as vehicle in control group and standard group received Withania somnifera (100 mg/kg) while C. paniculatus Willd ethanolic extract (100, 200, and 400 mg/kg) was given orally for 7 days. Results and Discussion: Change in immobility time in swim endurance, first clonic convulsion produced in anoxic tolerance test, immobility time in TST and open arms entry in elevated plus maze test was recorded as parameters. The ethanolic extracts of C. paniculatus Willd significantly reduces the immobility timing along with increases the swimming endurance time, and clonic convulsion timing in anoxic tolerance test in comparison of control group. In tail suspension significant decrease in immobility time and increased open arm entry in elevated plus maze were observed as compare to control group. Conclusion: C. paniculatus Willd has potential as a medicinal plant and it showed protective effect for the stress prevention as the alkaloids are present as main constituents.

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Section: Discussionmentioning

confidence: 99%

Neuropharmacological Screening, Anti-Stress Activity, and Toxicity Studies of Standardized Extract of the Seeds of Celastrus Paniculatus Willd

Singh¹,

Upadhyay‬²,

Sirbaiya³

2021

Asian J Pharm Clin Res

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“…Acorus calamus is a semi-aquatic perennial, aromatic herb with creeping rhizomes [5] which has been used traditionally as a medicine and also the powder of rhizome has a spicy flavour. Its rhizome is used to treat gastrointestinal problems that include inflammation of stomach, flatulence, ulcers and anorexia.…”

Section: Medicinal Plantsmentioning

confidence: 99%

“…Characterization of AgNPs were observed under SEM revealed that nanoparticles varied shaped (spherical and irregular) with size in the range of 50-200 µm (Figs. [3][4][5][6][7][8][9][10]. Spherical AgNPs aggregates were reported by [29] that synthesized AgNPs by Pleurotus sajorcaju of size range 5-50 µm and [30] who reported that their size range 5-50 µm AgNPs by A. bisporus, while [31] who obtained AgNPs prepared by Ganoderma lucidium showed the poly disperse nature of their nanoparticles with size range (10-70 µm).…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Green Synthesis, Characterization and Antioxidant Activity of Silver Nanoparticles in Extracts of Acorus calamus and Agaricus bisporus

Pipriya

Kundu

Tiwari

2018

IJBCRR

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Nanoparticles are in increasing commercial demand due to their wide applicability in various areas such as catalysis, chemistry, energy and medicine. Green chemistry is the best option to opt for the synthesis of nanoparticles. Agaricus bisporus and Acorus calamus are used medicinally in Ayurvedic medicines. The present work conducted endeavored to determine antioxidant activity of the extracts made. Silver nanoparticles were synthesized by using an aqueous extract of Acorus calamus & Agaricus bisporus. They were characterized by using UV spectrophotometer, Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Plant extracts were incubated with Silver Nitrate Solution (AgNO 3 ) and the color change was observed as dark reddish brown. The presence of Ag nanoparticles was analyzed between the wavelengths 400-550 nm. SEM & TEM determined the size of the nanoparticles determined by SEM Original Research Article

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“…E. hirta has been reported to possess numerous pharmacological activities such as, antioxidant, antiinflammatory and anticancer [12], wound healing potential [13], anthelmintic, angiotensin converting enzyme inhibitory, antidipsogenic, antiarthritis and galactogenic [8], antibacterial [14], antianaphylactic [15], antidiabetic [16], anxiolytic [17] and hepatoprotective [13,18]. In support of the dual medicinal use of E. hirta in opposing gut disorders like diarrhea and constipation, previous reports have shown unclear findings like, Tona et al [19] revealed non-specific antispasmodic action of E. hirta in the in vitro.…”

Section: Introductionmentioning

confidence: 99%

The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms

Ali

Mehmood

Saleem

et al. 2020

BMC Complement Med Ther

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Background: Euphorbia hirta (Linn) family Euphorbiaceae has been used in indigenous system of medicine for the treatment of gastrointestinal disorders. This study was designed to determine the pharmacological basis for the medicinal use of E. hirta in diarrhea and constipation. Methods: The aqueous-methanol extract of whole herb of E. hirta (EH.Cr) and its petroleum ether (Pet.EH), chloroform (CHCl 3 .EH), ethyl acetate (Et.Ac.EH) and aqueous (Aq.EH) fractions were tested in the in-vivo experiments using Balb/c mice, while the in-vitro studies were performed on isolated jejunum and ileum preparations of locally bred rabbit and Sprague Dawley rats, respectively, using PowerLab data system. Results: Qualitative phytochemical analysis showed the presence of alkaloids, saponins, flavonoids, tannins, phenols, cardiac glycosides, while HPLC of EH.Cr showed quercetin in high proportion. In mice, EH.Cr at the dose of 500 and 1000 mg/kg showed 41 and 70% protection from castor oil-induced diarrhea, respectively, similar to the effect of quercetin and loperamide, while at lower doses (50 and 100 mg/kg), it caused an increase in the fecal output. In loperamide-induced constipated mice, EH.Cr also displayed laxative effect with respective values of 28.6 and 35.3% at 50 and 100 mg/kg. In rabbit jejunum, EH.Cr showed atropine-sensitive inhibitory effect in a concentration-dependent manner, while quercetin and nifedipine exhibited atropine-insensitive effects. Fractions of E. hirta also produced atropine-sensitive inhibitory effects except Pet.EH and CHCl 3 .EH. On high (80 mM) and low (20 mM) K + − induced contractions, the crude extract and fractions exhibited a concentration-dependent non-specific inhibition of both spasmogens and displaced concentration-response curves of Ca ++ to the right with suppression of the maximum effect similar to the effect quercetin and nifedipine. Fractions showed wide distribution of spasmolytic and Ca ++ antagonist like effects. In rat ileum, EH.Cr and its fractions exhibited atropine-sensitive gut stimulant effects except Pet.EH. Conclusion: The crude extract of E. hirta possesses antidiarrheal effect possibly mediated through Ca ++ antagonist like gut inhibitory constituents, while its laxative effect was mediated primarily through muscarinic receptor agonist like gut stimulant constituents. Thus, these findings provide an evidence to the folkloric use of E. hirta in diarrhea and constipation.

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Anti-stress Activity of A Bioflavanoid: Quercetin from Euphorbia hirta

Cited by 10 publications

References 16 publications

Neuropharmacological Screening, Anti-Stress Activity, and Toxicity Studies of Standardized Extract of the Seeds of Celastrus Paniculatus Willd

Neuropharmacological Screening, Anti-Stress Activity, and Toxicity Studies of Standardized Extract of the Seeds of Celastrus Paniculatus Willd

Green Synthesis, Characterization and Antioxidant Activity of Silver Nanoparticles in Extracts of Acorus calamus and Agaricus bisporus

The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms

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