Anti-SmD1 antibodies are associated with renal disorder, seizures, and pulmonary arterial hypertension in Chinese patients with active SLE

Hu, Chao; Li, Mengtao; Liu, Jian; Qian, Jianfei; Xu, Dong; Zhang, Shulan; Li, Ping; Zhao, Jiulang; Tian, Xin; Zeng, Xiaofeng

doi:10.1038/s41598-017-08099-3

Cited by 12 publications

(10 citation statements)

References 27 publications

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“…The rate of anti-Sm antibody positivity in patients with SLE is 10% to 30%. 31 Although the detection rate is low (30%-40%), 32 the specificity is as high as 92.2% to 99%, and anti-Sm antibody positivity is thus included in the diagnostic criteria for SLE. The anti-Sm positivity rate in the current study was 64.74%.…”

Section: Discussionmentioning

confidence: 99%

Clinical aspects and risk factors of lupus nephritis: a retrospective study of 156 adult patients

et al. 2019

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Objective To analyze the clinical manifestations, laboratory indexes, disease activity, and pathological types of lupus nephritis (LN) in adult patients. Methods We retrospectively analyzed the clinical manifestations, laboratory indexes, and pathological classifications of 156 adult patients first diagnosed with LN between July 2013 and November 2017. Patients were categorized according to the following criteria: active or inactive LN, LN with or without renal damage, and mild or severe LN. Results Immunoglobulin G and A levels, 24-hour proteinuria, and anti-dsDNA, anti-Sm, and anti-ribosomal P protein antibody positivity rates were all significantly increased in patients with active LN compared with inactive LN. Anti-dsDNA antibody positivity and 24-hour proteinuria were significantly increased, whereas hemoglobin, serum albumin, and C3 and C4 levels were significantly decreased in patients with LN and renal damage compared with those without renal damage. Anti-dsDNA and anti-Sm antibody positivity rates and 24-hour proteinuria were significantly increased, while hemoglobin, serum albumin, C3 and C4 levels, and estimated glomerular filtration rate were significantly decreased in patients with severe LN compared with patients with mild LN. Conclusions LN can display various clinical manifestations, laboratory indexes, levels of disease activity, and pathological types in adult patients.

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Section: Discussionmentioning

confidence: 99%

Clinical aspects and risk factors of lupus nephritis: a retrospective study of 156 adult patients

et al. 2019

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“…Other autoantibodies with increased prevalence in NPSLE compared to SLE include antiphospolipid antibodies (APL) (OR: 2.1), lupus anticoagulants (OR: 1.9) and anti-cardiolipin antibodies (OR: 1.6). Smaller sized cohort studies addressed the association between antibodies and seizure disorders in SLE and suggested that anticardiolipin (aCL), APL and anti Sm antibody may increase seizure risk [43,44,56], conversely the presence of anti La antibodies might lower it [57]. Large scale studies are warranted to confirm this and to clarify the exact pathomechanism.…”

Section: Autoantibodies In Slementioning

confidence: 99%

Seizures as a clinical manifestation in somatic autoimmune disorders

Amanat

Thijs

Salehi

et al. 2019

Seizure

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A B S T R A C TThe risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto's encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and antibodies against neuronal antigens may contribute to the etiopathogenesis of seizures and epilepsy associated to immune conditions. Other unknown factors, the effect of different co-morbid conditions of epilepsy as well as shared risk factors such as common etiological factors, environmental triggers, or a common genetic predisposition may also explain the association. We review different autoimmune disorders which may present with co-morbid seizures and discuss possible underlying mechanisms of this co-occurrence focusing on a potential role of immune system dysfunction.

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“…Immune mechanisms can play an important role in several subtypes of epilepsies such as temporal epilepsy, Lennox-Gastaut syndrome, and others [30]. Moreover, it was found that SLE patients, positive for anti-SmD1 antibodies have a higher rate of seizures [31], whereas other studies suggested a role for mannose-binding lectin [32]. Huang et al [33] enrolled 2,203 patients with no history of seizure prior to SLE diagnosis and found that 157 (7.13%) had seizures [33].…”

Section: Discussionmentioning

confidence: 99%

Epilepsy among Systemic Lupus Erythematosus Patients: Insights from a Large Database Analysis

et al. 2017

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Objective: Epilepsy is characterized by a relevant epidemiological and clinical burden. In the extant literature, an increased risk of seizures has been described in several inflammatory/autoimmune disorders, including systemic lupus erythematosus (SLE). However, so far, relatively few and small size-based studies have been conducted. We aimed to investigate the link between seizure and SLE utilizing a large sample of subjects and extensive data analysis. Methods: Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of epilepsy in a cross-sectional study. Chi-square and t tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services. Results: The study included 5,018 patients with SLE and 25,090 age- and gender-frequency-matched controls. The proportion of epilepsy was found significantly higher among SLE patients (4.03 vs. 0.87%, p < 0.001). Using logistic regression, adjusting for multiple confounding factors, older age (≥70 years) resulted as negative predictor (OR 0.42 [95% CI 0.27–0.62], p <0.001), whereas the presence of SLE was a positive predictor of epilepsy (OR 4.70 [95% CI 3.94–5.82], p < 0.001). Interaction between SLE and elderly age resulted in high OR of 5.47 for epilepsy (95% CI 2.53–11.9). Conclusion: Our study confirms the higher prevalence of epilepsy in SLE patients. Physicians should be aware of such findings and have a lower threshold for suspecting epileptic seizures in these patients. Further studies are needed to better elucidate the mechanisms by which SLE favors the insurgence of seizures.

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Anti-SmD1 antibodies are associated with renal disorder, seizures, and pulmonary arterial hypertension in Chinese patients with active SLE

Cited by 12 publications

References 27 publications

Clinical aspects and risk factors of lupus nephritis: a retrospective study of 156 adult patients

Clinical aspects and risk factors of lupus nephritis: a retrospective study of 156 adult patients

Seizures as a clinical manifestation in somatic autoimmune disorders

Epilepsy among Systemic Lupus Erythematosus Patients: Insights from a Large Database Analysis

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