Clinical aspects and risk factors of lupus nephritis: a retrospective study of 156 adult patients

Fang, Yuan; Wei, Feili; Wang, Junjie; You, Yun

doi:10.1177/0300060519871812

Cited by 10 publications

(6 citation statements)

References 38 publications

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“…Our results were consistent with previous studies showing a higher prevalence of malar rash [17], serositis [18], pulmonitis [19], lymphadenopathy [20], necrotizing vasculitis [21], higher SLEDAI score [22], and lower prevalence of Raynaud's phenomenon [23], Sjogren's syndrome [24], and peripheral nervous system manifestations [25] in LN patients. SLE patients with LN had a higher frequency of arterial or venous thrombosis than non-renal SLE patients, while no differences were observed in regard to antiphospholipid syndrome and antiphospholipid antibodies positivity in line with literature data [26].…”

supporting

confidence: 93%

“…Besides, a higher proportion of LN patients had necrotizing vasculitis (9.2% vs 2.0%) and a history of arterial/venous thrombosis (9.7% vs 2.5%) compared to patients without kidney involvement. In addition, the SLEDAI score of LN patients was significantly higher (14 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) points vs 8 (4-14) points, p<0.001) than in non-renal SLE patients. The frequency of anemia, leukopenia, and thrombocytopenia did not differ significantly between the groups.…”

mentioning

confidence: 87%

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Lupus nephritis: clinical characteristics, serological associations, pattern of pro- and anti-inflammatory markers

Iaremenko

Koliadenko

Iaremenko³

et al. 2023

Ukr. J. Nephrol. and Dial.

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The present study aimed to investigate the prevalence, clinical, and laboratory characteristics of renal involvement in a large cohort of Ukrainian patients with systemic lupus erythematosus (SLE). Methods. A total of 380 patients with SLE were enrolled in this cross-sectional study, including 176 with lupus nephritis (LN) and 204 with non-renal SLE. Patients were reviewed for demographic details, clinical SLE manifestations, SLE Disease Activity Index 2000 (SLEDAI-2K), and SLICC/ACR Damage Index. Laboratory evaluations included complete blood count with an erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), high-sensitivity CRP (hs-CRP), anti-CRP antibodies, serum creatinine, complement C3 and C4 levels, urinalysis, 24-hour urine protein, specific autoantibodies, interleukin-6 (IL-6), IL-10. Results. There was a significantly higher frequency of malar rash, lymphadenopathy, splenomegaly, serositis, pulmonitis, fever, necrotizing vasculitis, and a history of arterial/venous thrombosis in patients with LN; while Raynaud’s phenomenon, Sjogren’s syndrome, peripheral nervous system manifestations occurred more often in patients with non-renal SLE. Patients with LN were found to have higher ESR levels and lower IL-10 levels. Either frequency of anti-dsDNA positivity and its titer were higher in the LN group with no differences regarding other autoantibodies. C3 and C4, CRP, hs-CRP, anti-CRP, and IL-6 levels showed no significant difference between the groups. Multivariate analysis demonstrated that LN was positively associated with pulmonitis (OR 5.34 (95% CI 1.88-15.10), p=0.002), arterial/venous thrombosis (OR 6.80 (95% CI 1.87-24.70), p=0.004), anti-dsDNA positivity (OR 6.22 (95% CI 1.89-20.50), p=0.003), higher SLEDAI-2K score (OR 1.15 (95% CI 1.08-1.23), p<0.001) and negatively associated with Raynaud’s syndrome (OR 0.20 (95% CI 0.08-0.49), p<0.001) and younger age at disease onset (OR 0.96 (95% CI 0.93-0.99), p=0.003). In the LN group, 27 patients (15.3%) had nephrotic syndrome. In multivariate logistic analysis, male sex (OR 5.21 (95% CI 1.77-15.30), p=0.003) and higher SLICC/ACR score (OR 2.12 (95% CI 1.45-3.09), p<0.001) were associated with increased risk of nephrotic syndrome, whereas lymphadenopathy (OR 0.31 (95% CI 0.12-0.80), p=0.02) was associated with decreased risk of nephrotic syndrome development. Conclusions. Our cohort of Ukrainian LN patients showed different characteristics in demographic, clinical, and laboratory findings compared to patients with non-renal SLE. These features are mostly on par with LN patients of other nationalities around the world.

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confidence: 93%

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confidence: 87%

Lupus nephritis: clinical characteristics, serological associations, pattern of pro- and anti-inflammatory markers

Iaremenko

Koliadenko

Iaremenko³

et al. 2023

Ukr. J. Nephrol. and Dial.

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“…Increased urea levels are associated with impaired kidney function. About 50% of SLE patients have kidney damage including glomerular and tubulointerstitial pathology, and 100% of SLE patients have varying degrees of renal pathological changes. , Previous studies have shown that in female MRL/lpr mice, the urinary protein creatinine ratio, which reflects the degree of kidney damage, was significantly increased at 13 weeks of age . This is consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

Time Course of Metabolic Alterations Associated with the Progression of Systemic Lupus Erythematosus in MRL/lpr Mice Based on GC/MS

Zhang

Wang

et al. 2020

J. Proteome Res.

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Exploring the dynamic changes of metabolites and metabolic pathways during the development of the disease can help to further understand the etiology and pathogenesis of systemic lupus erythematosus (SLE). In this study, serum metabolomics based on gas chromatography/mass spectrometry (GC/MS) was employed to investigate the metabolic alterations at different stages of SLE using lupus-prone mice (MRL/lpr) of 9, 11, and 13 weeks of age. Multivariate statistical analysis was performed to view the alterations of metabolic profiles between MRL/lpr mice and age-matched C57BL/6 mice, and t-test and fold change criteria were used to identify differential metabolites at each stage. 11 changed metabolites were found in MRL/lpr mice at 9 weeks of age, which were mainly involved in the tricarboxylic acid (TCA) cycle, glycolysis, and butanoate metabolism; with the increase of week age, the TCA cycle was still disturbed, and the biosynthesis of fatty acids was significantly upregulated since 11 weeks of age; in addition, urea, urate, and indole-3-lactate were increased at 13 weeks of age. We found a time course of metabolic alterations in MRL/lpr mice, which may be related to the progression of SLE. These findings could provide a reference for studying the mechanism of SLE and judging the pathological stage and severity of the disease. The MS data have been deposited in Mendeley (https://www.mendeley.com/).

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“…Finally, low albumin was also associated with depression. Low serum albumin correlates with kidney disease [ 23 ] and outcomes in lupus nephritis [ 24 ]. These kidney findings are especially interesting given that none of the JSLE patients were diagnosed with lupus nephritis.…”

Section: Discussionmentioning

confidence: 99%

Kidney Function, Age, and Education as Contributors to Depression and Anxiety in Juvenile Systemic Lupus Erythematosus

Figueiredo-Braga

Silva

Ganhão

et al. 2021

EJIHPE

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Juvenile systemic lupus erythematosus (JSLE) is diagnosed in children younger than 18 years of age. Depression and anxiety are common, but not well understood in JSLE. We investigated the clinical and psychological factors associated with the psychological manifestations of JSLE. Twenty-nine JSLE patients were recruited for the study. Patients completed surveys evaluating their psychological status and perceptions about their health. Medical records were used to obtain laboratory results. The JSLE patient population was compared with adult-onset SLE (ASLE) patients and unaffected controls. Kidney involvement was associated with depression in the JSLE patients. The BUN levels, BUN/creatinine ratio, and leukocyturia were all significantly associated with depressive symptoms. Multivariate analysis found that the BUN/creatinine ratio was the most predictive value for both depression and anxiety. Depressive symptoms in JSLE were less pronounced than in ASLE, although anxiety was not different. Age and education are likely to be protective against depression in the JSLE patients. These findings may indicate that symptomatology is an important indicator of whether the patient needs psychiatric care.

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Clinical aspects and risk factors of lupus nephritis: a retrospective study of 156 adult patients

Cited by 10 publications

References 38 publications

Lupus nephritis: clinical characteristics, serological associations, pattern of pro- and anti-inflammatory markers

Lupus nephritis: clinical characteristics, serological associations, pattern of pro- and anti-inflammatory markers

Time Course of Metabolic Alterations Associated with the Progression of Systemic Lupus Erythematosus in MRL/lpr Mice Based on GC/MS

Kidney Function, Age, and Education as Contributors to Depression and Anxiety in Juvenile Systemic Lupus Erythematosus

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