Anti‐Sd<sup>a</sup>, a New Blood Group Antibody

Renton, P. H.; Howell, Peter; Ikin, Elizabeth W.; Giles, Carolyn M.; Goldsmith, D.

doi:10.1111/j.1423-0410.1967.tb03796.x

Cited by 60 publications

(24 citation statements)

References 4 publications

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“…Anti-AnA produced haemolysis up to dilutions of % in the presence of neat serum and in tests with neat anti-AnA haemolysis took place up to a 1/10 dilution of fresh A or AB serum. Weak haemolytic activity manifested itself by inhibition of agglu tination as reported by Renton et al for genuine antibodies plus complement [7], The fact that haemolysis was and by heating of fresh serum also suggests the participation of 'complement' in this type of haemolysis by an antibody-like sub stance. So far we have found haemolytic activity only in saline extracts of the albumen gland and in egg contents of H. aspersa; lectins and other antibody-like substances gave consistently negative 15 inhibited by EDTA results.…”

Section: Haemolysis Testsmentioning

confidence: 83%

Serological Differences Between Related Species of Snails

Gold¹,

Thompson²

1969

Vox Sanguinis

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The presence of B substance in saline extracts of albumen glands of Helix pomatia has been reported by Kim et al. [5] and the agglutination of Hela cells by anti-Aiiei mentioned by Uhlenbruck et al. [10]. We report in this paper serological differences between related species of snails revealed by haemolysis, agglutination of Hela cells and presence of B-like substance. The same snail substances have been used as in Part I of this report. Saline extracts of seeds were prepared as described in [2] and anti-BsT was the same as that used for experiments in Part I of this report.

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Section: Haemolysis Testsmentioning

confidence: 83%

Serological Differences Between Related Species of Snails

Gold¹,

Thompson²

1969

Vox Sanguinis

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“…The Sd blood group system was first de scribed in 1967 by Macvie et al [1] and Ren ton et al [2], Approximately 96% of the pop ulation have the Sda antigen present on their red blood cells or in their urine [3]. Rare individuals have a very strong Sda antigen, denoted as Sd(a++) [4].…”

Section: Introductionmentioning

confidence: 99%

The Serology of Sd^a Effects of Transfusion and Pregnancy

Spitalnik¹,

Cox²,

Spennacchio³

et al. 1982

Vox Sanguinis

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Pre- and posttransfusion antibody titers were performed on 6 patients with anti-Sd^a transfused with incompatible blood. In 3 of these patients a significant rise in IgG antibody titer was found. The data suggest that in occasional patients the Sda antigen does evoke a secondary immune response. We evaluated 245 pregnant women for the presence of Sd^a and found that 30% were Sd(a-). This incidence was significantly higher than that found in normal blood donors (4%), but was lower than that described in previous reports. We found that 22% of pregnant women in their first trimester were Sd(a-) whereas at term 36% were Sd(a-). These significantly different incidences of antigen positivity suggest decreased antigen expression with progressing pregnancy, as seen in the Lewis system. No difference was found in the incidence of anti-Sd^a between pregnant women, either during their first trimester or at term, and normal donors.

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“…In 1967, a new human blood group char acter, called Sda, was found by two groups of English workers [3,8], who classified the individuals in two phenotypes, Sd(a+) and Sd(a-); the incidence of the Sd(a+) red cell phenotype was over 90%. The peculiarity of this blood group is that the human naturally occurring antibodies agglutinate only a pro portion of red cells, even from donors with high expression of Sda antigen.…”

Section: Introductionmentioning

confidence: 99%